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Our top choices for Santa Isabel hotels

San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included
2.0 star property
Narganá
San Blas Paradise Private Cabins on Shipwreck Island - meals included

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island
2.0 star property
Narganá
Private Ocean-Front Cabin with private bathroom on San Blas Island

Trips Guna Yala

Trips Guna Yala
2.0 star property
Narganá
The price is NT$3,253
NT$7,555 total
includes taxes & fees
Dec 31 - 2026/1/1
Trips Guna Yala

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS
3.0 star property
Narganá
The price is NT$61,725
NT$67,898 total
includes taxes & fees
Jan 11 - 2026/1/12
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cabins in Asserya Island - San Blas paradise - meals included

Cabins in Asserya Island - San Blas paradise - meals included
2.0 star property
Narganá
Cabins in Asserya Island - San Blas paradise - meals included

Cabins on paradise San Blas island

Cabins on paradise San Blas island
2.0 star property
Narganá
Cabins on paradise San Blas island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Isabel Hotel Reviews

More cheap stays in Santa Isabel

Find out more about Santa Isabel

Top reasons to visit Santa Isabel

  • Pristine Beaches: Santa Isabel boasts stunning beaches perfect for sunbathing and water activities.
  • Outdoor Adventures: Explore scenic hiking trails and captivating national parks that showcase the region's natural beauty.
  • Cultural Experiences: Immerse yourself in local culture through museums and authentic experiences.
  • Charming Accommodations: Choose from a variety of lodges and hotels with breathtaking coastal views.
  • Family-Friendly Activities: Enjoy a range of activities suitable for all ages along the southern coast.

Find great hotels near Santa Isabel

Discover a variety of hotel accommodations in Santa Isabel, Colón, Panama, perfect for your beach getaway. From charming lodges to comfortable hotels, you'll find options that cater to every traveler's needs. Enjoy the stunning coastal views and explore the best amenities available. With numerous hotel reviews and easy search options, planning your ideal stay has never been easier. Experience the beauty of Santa Isabel with a perfect home base for your vacation adventures.

  • Cabins on Paradise San Blas Island: Nestled 25.7km from Santa Isabel, Cabins on Paradise San Blas Island offers a serene escape with its delightful cabins set amidst tropical beauty. This hotel features a range of dining options including a Snack Bar and complimentary local breakfast. Guests can enjoy free breakfast daily, ensuring a delightful start to their day. The cozy atmosphere and lush surroundings make it an ideal spot for relaxation and rejuvenation.
  • Cabañas Nalunega San Blas: Located 27.4km from Santa Isabel, Cabañas Nalunega San Blas is a charming lodge perfect for adventurous travelers. The property features a restaurant that serves breakfast, and guests can indulge in delicious meals at affordable rates. For those seeking excitement, the lodge offers onsite boat tours, allowing guests to explore the stunning waters of San Blas. With a mix of comfort and adventure, this lodge is a great choice for those looking to experience the local culture and nature.
  • Cabañas Isla Nubesidub San Blas: Also situated 27.4km from Santa Isabel, Cabañas Isla Nubesidub San Blas provides a quaint lodge experience with direct access to the beach. Ideal for beach lovers, the property invites guests to unwind by the sea and soak up the sun. With its emphasis on a beach vacation experience, visitors can enjoy the soothing sounds of the ocean and the beauty of the surrounding landscape, making it a perfect retreat for relaxation and leisure.

Where to stay near Santa Isabel

Santa Isabel offers a delightful blend of beach and outdoor adventures, making it an ideal vacation spot. Stroll along the oceanfront, soak in stunning city views, and explore the nearby southern coast for family-friendly activities. Don't miss the charm of Old Havana and its vibrant atmosphere, all while enjoying the strategic location that places you close to both urban and natural wonders. This destination guarantees an unforgettable experience for every traveler.

  • Playa Chiquita: Situated 11.3km from Santa Isabel, Playa Chiquita is a charming village known for its beautiful beaches and vibrant local culture. The peak travel season runs from January to March, attracting visitors eager for outdoor adventures and cultural experiences. Here, you can relax on the sandy shores, explore historical ruins, and enjoy family-friendly beach activities. The serene atmosphere makes it an ideal spot for sunbathing, swimming, and soaking in the local ambiance.
  • Miramar: Located 16.1km away from Santa Isabel, Miramar is a picturesque city that offers a delightful blend of outdoor activities and beach experiences. The city sees its highest visitor numbers between January and March, with fewer crowds during the summer months. Visitors can explore the nearby islands, which offer stunning views and opportunities for water sports. Whether you're looking to relax by the beach or engage in an adventurous day trip, Miramar has something for everyone.
  • Palenque: Just 19.3km from Santa Isabel, Palenque is a bustling city that attracts families and beach lovers alike. While its visitor numbers peak between January and March, the city remains a vibrant destination year-round. Enjoy shopping at local malls, unwind at resorts, and take part in various family-friendly activities. With beautiful beaches, parks, and a research facility nearby, Palenque offers a perfect mix of urban life and natural beauty.

Things to do near Santa Isabel

Santa Isabel offers a perfect escape for beach and outdoor enthusiasts, featuring inviting outdoor seating and a variety of activities. Explore scenic hiking trails that showcase the region's natural beauty, enjoy authentic local experiences, and indulge in a relaxing spa show for a rejuvenating retreat. Whether you’re looking to unwind or embark on an adventure, Santa Isabel has something for everyone.

Shopping

In Santa Isabel, you can shop at local markets for unique souvenirs and gifts. If you're up for a drive, visit Albrook Mall, about 64.4km away, which offers a wide range of shops from clothing to electronics and plenty of dining options.

Recreation

In Santa Isabel, indulge in rejuvenating treatments at the serene Spa de la Isla, surrounded by lush tropical gardens. For relaxation, visit the tranquil beaches for yoga sessions and meditation, or explore the nearby nature trails for a refreshing hike amidst breathtaking scenery.

Adventure

Explore the Honeycreeper Ridge Trail, located 33.8km from Santa Isabel, for an exhilarating hiking experience. Immerse yourself in the stunning scenery and embrace the outdoor adventure as you traverse the lush landscapes, encountering diverse wildlife along the way.

Nightlife

Experience the vibrant nightlife in Santa Isabel by visiting the lively La Cueva Bar for refreshing cocktails and dancing. For a more laid-back vibe, check out El Patio for delicious tapas and live music, where you can unwind and soak up the local atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Isabel

To save money on your trip to Santa Isabel, plan your visit during the cheaper months of January, March, or May. Booking your hotel 1-3 months in advance is recommended, and check for last-minute deals on sites like Expedia. Tuesdays are the least expensive days to stay, while Wednesdays are the most costly. Utilize Expedia's search tools to sort by price and filter for eco-certified hotels. Consider booking a package that combines flights, hotel, and activities for additional savings. Walking is a great way to explore and save on transportation costs.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Isabel are January, March and May, where the prices are slightly lower. This is in comparison to July and October to November, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel in Santa Isabel is usually 1-3 months out from when you are planning to stay. If you're a little more spontaneous, you could also peruse Expedia's last minute deals which could secure you a cheaper stay. Look out for the green banner below the price to spot the deals.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Isabel is Tuesday. The most expensive day to stay in Santa Isabel is Wednesday.
  • Find cheap hotels on Expedia: Expedia's search tool enables you to set your budget and choose your ideal location, among other preferences. You can organize your search results to display prices starting from the lowest to help you find the most affordable hotels first. Additionally, you can refine your options by hotel type; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally friendly hotels that are available for booking.
  • Consider bundling your trip: You can save money by booking an Expedia package that combines your hotel stay in Santa Isabel with your flights and activities.

Find the best attractions near Santa Isabel

Santa Isabel, located in Colón, Panama, is perfect for beach and outdoor vacations. Visitors can explore captivating national parks, local museums, and scenic rivers. This destination offers a blend of natural beauty and cultural experiences, making it ideal for travelers seeking adventure and relaxation. Don’t miss out on the picturesque Santa Isabel Island and discover some of the best resorts in the area for a memorable stay.

  • Porvenir Museum: Located 22.5km from Santa Isabel, this museum immerses visitors in the rich culture and history of the indigenous people of Panama. Expect to see fascinating artifacts and engaging exhibitions that highlight the region's heritage.
  • Chagres National Park: Just 30.6km away, this national park offers stunning scenery and a variety of outdoor adventures. Hike through lush trails, spot diverse wildlife, and enjoy activities like kayaking and birdwatching in a breathtaking natural setting.
  • Mamoní River: Situated 29.0km from Santa Isabel, the Mamoní River invites you to experience its tranquil waters and picturesque surroundings. Enjoy activities such as rafting or simply relax by the riverbank, taking in the serene landscape.

The nearest major airports for your trip to Santa Isabel

Traveling to Santa Isabel, Colón, Panama, can be conveniently achieved via three major airports. Tocumen International Airport (PTY) is 56.3km away, with nearby luxury hotels like The Santa Maria (8.0km) and JW Marriott Panama (16.1km), both offering shuttle services. Marcos A. Gelabert International Airport (PAC) is 74.0km from Santa Isabel, with excellent options such as Waldorf Astoria Panama (3.2km) and The Westin Playa Bonita (8.0km), providing various transportation services. Lastly, Balboa Airport (BLB) is 82.1km away, featuring hotels like Hilton Panama (9.7km) and Bristol Panama (9.7km), both offering shuttle options and transfers to the airport.

Frequently asked questions

What's the best place to stay in Santa Isabel?
Located 17 mi (27.3 km) from the heart of Santa Isabel, Cocoloco - Catamaran Lagoon 52F SAN BLAS is a top choice for your stay based on our traveler data. Two other choices for your visit to the area are San Blas Paradise Private Cabins on Shipwreck Island - meals included and Private Ocean-Front Cabin with private bathroom on San Blas Island. See all available top hotels, or vacation rentals in Santa Isabel.
If I need to cancel my hotel reservation in Santa Isabel, will I receive a refund?
Yes! The majority of room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Isabel.
Where can I learn more about changing or cancelling my trip to Santa Isabel?
For additional details about rescheduling or cancelling your trip to Santa Isabel, go to https://www.expedia.com/service/.
What's the best place to stay near Tocumen International Airport (PTY)?
Crowne Plaza Panama Airport is a popular 4-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.4 km) from Tocumen Intl. Airport. Other good options within close proximity to the airport include Riande Aeropuerto Hotel & Casino and Express Inn Panama International Airport Hostel.
What is staying in Santa Isabel like?
Visitors can enjoy all that Santa Isabel has to offer including its parks. There are 44 hotels and other accommodations in the surrounding area. Find out more about Santa Isabel.
What are the top places to visit in Santa Isabel?
Places to visit in the wider area include Chagres National Park, Museum, and Porvenir Museum. Check out what more to see and do in Expedia's Santa Isabel guide.
What's the seasonal weather like in Santa Isabel?
The hottest months are usually June and September with an average temp of 80°F, while the coldest months are February and March with an average of 78°F. The rainiest months in Santa Isabel are October, August, July, and November, with each month seeing an average of 12 inches of rainfall.