A large brick church with two bell towers and palm trees in front.

Find hotels in Santa Cruz de la Sierra

Check prices for these dates

Tonight
Oct 4 - Oct 5
Tomorrow
Oct 5 - Oct 6
Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Filter by

Star rating

Guest rating

Our top choices for Santa Cruz de la Sierra hotels

A historic stone courtyard with cobblestone flooring, a central fountain, and buildings with traditional architecture.
A swimming pool with lounge chairs and a stone building in the background.
A banquet hall with round tables, red chairs, and a high arched ceiling.
A bar area with a round mirror, wooden stools, and a tiled floor.

1. Parador de Trujillo

Parador de Trujillo
Trujillo
United States
wilton
NT$3,575
NT$3,932 total
includes taxes & fees
Oct 13 - Oct 14
Parador de Trujillo
A stone building with a tiled roof, a stone patio, and a grassy area.
A checkered floor, a staircase, and a reception desk in a building with yellow walls and green doors.
A rustic bar area with wooden stools, a checkered tablecloth, and a brick wall.
A restaurant with stone walls, wooden beams, and checkered tablecloths. Tables are arranged in rows with chairs.

2. Hospedium Hotel Soterraña

Hospedium Hotel Soterraña
Madronera
United States
Jose Luis
NT$2,282
NT$2,510 total
includes taxes & fees
Oct 5 - Oct 6
Hospedium Hotel Soterraña
A historic building with a sign for "Eurostars" and a large entrance door.
A swimming pool with lounge chairs and a tower structure in the background.
A dining area with tables and chairs, large windows, and a view of the city.
A reception area with a wooden counter, a glass door, and a stone wall.

3. Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta
Trujillo
United Kingdom
Elizabeth
NT$2,575
NT$2,833 total
includes taxes & fees
Oct 6 - Oct 7
Eurostars Palacio Santa Marta
A courtyard with white buildings, a cobblestone path, and potted plants.
A white-walled room with a large arched mirror, a red vase with green plants, and wooden boxes on a bench.
A covered outdoor seating area with a stone floor, white walls, and arches.
A dining area with a wooden table, chairs, a patterned rug, a window with a view of trees, and a bookshelf.

4. Finca El Azahar

Finca El Azahar
Trujillo
Canada
Alex
NT$4,929
NT$5,422 total
includes taxes & fees
Oct 5 - Oct 6
Finca El Azahar
A lobby with a wooden cart displaying food and drinks, surrounded by arches and potted plants.
A corridor with red walls, stone columns, and a tiled floor.
A spacious courtyard with red seating and tables, stone arches, and potted plants.
A banquet hall with a long table set for a formal event, arched ceilings, and a view of the upper level.

5. Hotel Izan Trujillo

Hotel Izan Trujillo
Trujillo
Spain
Monica
NT$2,941
NT$3,235 total
includes taxes & fees
Oct 13 - Oct 14
Hotel Izan Trujillo
A stone-walled hallway with a dark door, a staircase, and a potted plant.
A stone-walled corridor with a tiled floor, a black bookshelf, and a potted plant.
A spacious living area with wicker furniture, a stone wall, and a view of the outside.
A sign reading "PLAZA SANDRA" on a textured wall, with a tiled pool in front.

6. Plaza Sandra

Plaza Sandra
Trujillo
United States
Juan
NT$2,033
NT$2,237 total
includes taxes & fees
Oct 28 - Oct 29
Plaza Sandra
A restaurant with checkered tablecloths, wooden chairs, and a stone wall.
A hallway with a brick archway, a staircase, and a potted plant.
A stone building with a sign reading "Hotel Center."
A stone building with a sign that reads "RESORT".

7. Hostal Hueso

Hostal Hueso
Trujillo
United States
ALFRED
NT$2,119
NT$2,331 total
includes taxes & fees
Oct 5 - Oct 6
Hostal Hueso
A stone-walled dining area with tables set for two, each with a red tablecloth and wine glasses.
A garden with various flowering plants and a stone wall in the background.
A room with a bed, a wooden chair, and a vase with branches.
A hallway with a potted plant, a glass door leading outside, and a red lamp on a table.

8. Hostal León

Hostal León
Trujillo
United Kingdom
Gareth
NT$1,793
NT$1,972 total
includes taxes & fees
Oct 5 - Oct 6
Hostal León
A sunset view with a stone pathway, trees, and a fence.
A modern building with a white facade, a red-tiled roof, and a large tree in the center.
A wine cellar with wooden racks and a bar area.
A modern hotel room with a large bed, a flat-screen TV, a desk with a phone and a small table, and a view of the city through large windows.

9. Finca la Desa

Finca la Desa
Miajadas
New Zealand
Craig
NT$2,217
NT$2,438 total
includes taxes & fees
Oct 5 - Oct 6
Finca la Desa
A bed with a wooden headboard, two pillows, a bedside lamp, and a patterned bedspread.
A bathroom with a bathtub, sink, toilet, and a hand sanitizer dispenser.
A plaza with historic buildings, a fountain, and parked cars.
A bedroom with two beds, each with a patterned pillow and a wooden headboard.

10. Alojamientos Plaza Mayor

Alojamientos Plaza Mayor
Trujillo
United States
Adela
NT$1,115
NT$1,226 total
includes taxes & fees
Oct 5 - Oct 6
Alojamientos Plaza Mayor
A hotel room with a large bed, two bedside tables, a nightstand, a door leading to a bathroom, and a wall-mounted light fixture.
A compact living space with a kitchenette, dining area, and a TV.
A building with a sign reading "Ruralis El Altozano".
A compact kitchen with wooden cabinets, a stainless steel range hood, a microwave, and a refrigerator. There is a dining table with chairs and a coffee maker.

11. Hostal Ruralis Altozano

Hostal Ruralis Altozano
Montánchez
Spain
MARCO ANTONIO
NT$1,452
NT$1,598 total
includes taxes & fees
Oct 7 - Oct 8
Hostal Ruralis Altozano
An outdoor dining area with tables and chairs, a white canopy, and potted plants.
A conference room with rows of chairs, a projector screen, and a speaker.
A buffet area with a glass display case, a counter with a coffee machine, and a seating area with a striped column.
A hotel room with a bed, a sofa, a desk, and a chair. There is a painting on the wall and a lamp on the desk.

12. Hospedium Hotel Triana

Hospedium Hotel Triana
Miajadas
United Kingdom
tina
NT$2,738
NT$3,012 total
includes taxes & fees
Oct 7 - Oct 8
Hospedium Hotel Triana
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Santa Cruz de la Sierra

Head to Plaza Mayor and Pizarro House Museum—just two of the sights around Santa Cruz de la Sierra.

See all hotels in Santa Cruz de la Sierra
A large brick church with two bell towers and palm trees in front.

Top Santa Cruz de la Sierra Hotel Reviews

Parador de Trujillo

Parador de Trujillo

8/10 Good
"Clean room Staff very nice steak was tough Breakfast ok"
Beryl 1-night trip
Posted 5 days ago
Parador de Trujillo
Hotel Izan Trujillo

Hotel Izan Trujillo

10/10 Excellent
"Nice hotel with a secure room for cycles for those on tour like me. Nice rooms and good facilities. Restaurant is good but also great places to eat on the Plaza."
Mark 1-night trip
Posted 2 months ago
Hotel Izan Trujillo
Plaza Sandra

Plaza Sandra

10/10 Excellent
"Era un lugar limpio y acogedor, y había muchos sitios a los que se podía ir andando. El personal fue muy atento. Aparcar fue todo un reto, sobre todo cerca del mercado semanal. Pasamos una estancia muy agradable."
Alexandra 3-night trip
Posted 3 months ago
Plaza Sandra
Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta

10/10 Excellent
"We had a wonderful stay at Eurostars Palacio Santa Marta. The hotel is set inside a beautifully restored historic building just steps from Plaza Mayor, making it perfect for exploring Trujillo on foot. Our room was spacious, comfortable, and very quiet. Alba was warm, welcoming, and made everything easy. Overall, an excellent stay in a charming location — we’d happily return."
Ismael 1-night trip
Posted 4 months ago
Eurostars Palacio Santa Marta

More cheap stays in Santa Cruz de la Sierra

Hostal León

Hostal León

Campillo 11 Trujillo Caceres
Get rates
7.6/10 Good! (55 reviews)
Hostal León
Posada dos Orillas

Posada dos Orillas

Calle Cambrones N6-8 Trujillo
Get ratesPosada dos Orillas
Hostal Hueso

Hostal Hueso

Calle Arquillo, 4 Trujillo Cáceres
Get rates
8.2/10 Very Good! (26 reviews)
Hostal Hueso
Hostal San Miguel

Hostal San Miguel

Plaza San Miguel, 3 Trujillo Caceres
Get rates
8.4/10 Very Good! (51 reviews)
Hostal San Miguel
HOTEL RURAL EL LABRIEGO BY VIVERE STAYS

HOTEL RURAL EL LABRIEGO BY VIVERE STAYS

C. Tiendas 7 Plasenzuela Cáceres
Get rates
9.2/10 Wonderful! (19 reviews)
HOTEL RURAL EL LABRIEGO BY VIVERE STAYS
Hostal - Restaurante Emilia

Hostal - Restaurante Emilia

PLAZA DEL CAMPILLO, 28 Trujillo CACERES
Get rates
9.2/10 Wonderful! (22 reviews)
Hostal - Restaurante Emilia

Frequently asked questions

What's the best place to stay in Santa Cruz de la Sierra?
Hotel Izan Trujillo, located 0.1 mi (0.1 km) from the heart of Santa Cruz de la Sierra, is a top choice for your stay based on our traveler data. Other good options for your stay in the area are Eurostars Palacio Santa Marta and Parador de Trujillo. See all available top hotels, or vacation rentals in Santa Cruz de la Sierra.
If I need to cancel my hotel reservation in Santa Cruz de la Sierra, will I receive a refund?
Yes! Most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz de la Sierra.
Where can I learn more about changing or cancelling my trip to Santa Cruz de la Sierra?
To find more details about updating your trip to Santa Cruz de la Sierra or cancelling it, head over to our customer service page.
What are some accommodations with pools in Santa Cruz de la Sierra?
Hotel Izan Trujillo: Offers complimentary wired internet access, a seasonal outdoor pool, and LED televisions. View all hotels with pools in Santa Cruz de la Sierra.
What's the best accommodation near Adolfo Suarez Madrid-Barajas Airport (MAD)?
Madrid Marriott Auditorium Hotel & Conference Center is a popular 4-star hotel featuring 2 restaurants and 2 bars. It's located a short 1.4 mi (2.2 km) from Adolfo Suarez Madrid-Barajas Airport. Other accommodations close to the airport are Hotel Clement Barajas and Meliá Barajas.
What's it like to stay in Santa Cruz de la Sierra?
Those traveling to Santa Cruz de la Sierra are sure to enjoy the sights to see and things to do. In Santa Cruz de la Sierra, there are 9 hotels and other accommodations to choose from. Find out more about Santa Cruz de la Sierra.
What is there to see in Santa Cruz de la Sierra?
Places to visit in the wider area include Plaza Mayor, Pizarro House Museum, and Trujillo Castle. You'll also find Museo de Vino y Queso and Juan Pizarro de Orellana Palace in the area. Check out what more to see and do in Expedia's Santa Cruz de la Sierra guide.
What's the seasonal weather like in Santa Cruz de la Sierra?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 47°F. Average annual precipitation for Santa Cruz de la Sierra is 22 inches.