Photo by Mike McClain

Find hotels in Puxico, MO from NT$1,771

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Our top choices for Puxico hotels

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (332)
"Room was nice and spacious."
United States
Rebecca
The price is NT$2,130
NT$2,392 total
includes taxes & fees
Dec 23 - Dec 24
Dexter Inn

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (252)
"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "
United States
Michelle
The price is NT$1,878
NT$2,108 total
includes taxes & fees
Jan 20 - 2026/1/21
Econo Lodge Dexter

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (387)
"Very nice"
United States
Dennis
The price is NT$2,391
NT$2,685 total
includes taxes & fees
Dec 25 - Dec 26
Travelodge by Wyndham Dexter

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (131)
"Excellent experience overall. The rooms were neat and hygienic, with all basic amenities available. Staff was courteous and quick to assist. Check-in and check-out were smooth. The location is convenient and safe. Great value for money. Highly recommended for both business and leisure stays"
United States
Amber
The price is NT$1,408
NT$1,771 total
includes taxes & fees
Jan 20 - 2026/1/21
OYO Hickory House Inn

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (4)
"Staff was helpful and professional. The rooms were clean and comfortable "
United States
Michael
The price is NT$3,339
NT$3,749 total
includes taxes & fees
Jan 1 - 2026/1/2
Hampton Inn By Hilton Dexter

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (84)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (968)
"Nice room helpful staff. "
United States
Deborah
The price is NT$3,345
NT$3,779 total
includes taxes & fees
Dec 27 - Dec 28
Drury Inn & Suites Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
United States
Teresa
The price is NT$3,273
NT$3,698 total
includes taxes & fees
Jan 9 - 2026/1/10
Fairfield Inn & Suites by Marriott Poplar Bluff

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (212)
"Had to "
United States
Brenda
Bullwinkles Rustic Lodge

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is NT$3,556
NT$3,982 total
includes taxes & fees
Jan 10 - 2026/1/11
Hampton Inn Poplar Bluff

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (625)
"The lady at the front was very nice. "
United States
Travis
The price is NT$1,797
NT$2,031 total
includes taxes & fees
Jan 11 - 2026/1/12
Super 8 by Wyndham Poplar Bluff Missouri

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (399)
"it was a nice stay, room was a little warm, thermostat may need changing out. Other than that it was great. "
United States
Jim
The price is NT$2,916
NT$3,295 total
includes taxes & fees
Jan 2 - 2026/1/3
Comfort Inn Poplar Bluff North

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (705)
"Amazing place"
United States
Mladen
The price is NT$3,472
NT$3,922 total
includes taxes & fees
Dec 31 - 2026/1/1
Holiday Inn Poplar Bluff by IHG

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1004)
"Love the updated rooms and the vending area."
United States
Kathi
The price is NT$2,399
NT$2,530 total
includes taxes & fees
Dec 23 - Dec 24
Motel 6 Poplar Bluff, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

More cheap stays in Puxico

Hotels in Puxico with star-rating

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay based on our traveler data. Two other choices for your trip to the area are Fairfield Inn & Suites by Marriott Poplar Bluff and Drury Inn & Suites Poplar Bluff. See all available top hotels, or vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
Where can I learn more about changing or cancelling my trip to Puxico?
To find more details about picking new dates or cancelling your trip to Puxico, click here.
What is staying in Puxico like?
Travelers to Puxico will find plenty to explore and enjoy. There are 54 hotels and other accommodations in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favorite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Check out what more to see and do in Expedia's Puxico guide.
What's the seasonal weather like in Puxico?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Puxico is 59 inches.

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