Find Resorts & Hotels with Spas in Palmyra, MO

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Check availability on Palmyra Resorts & Hotels with Spas

Our top choices for Palmyra hotels with a spa

Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
Hannibal
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is NT$2,533
NT$3,003 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Inn & Suites - Hannibal
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
Quincy
8.8 out of 10, Excellent, (603)
"Overall very nice property. "
United States
Jeffrey
The price is NT$3,496
NT$3,985 total
includes taxes & fees
Jan 2 - 2026/1/3
Holiday Inn Quincy East by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Palmyra Hotel Reviews

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

10/10 Excellent
"Easy check in"
Rickayla 2-night trip
Posted 5 days ago
Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

Frequently asked questions

Looking to vacation at a spa hotel in Palmyra?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the museums and coffeehouses in Palmyra—your day trip starts here. Spa hotels are the perfect way to break out of your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Palmyra?
Enjoy all that Palmyra has to offer and visit Mississippi River, Gardner House Museum, and Dr. J.W. Well Nature Park. If you have a little extra time during your trip, you might want to check out Flower City Park and Bay Island.
What is a Palmyra spa hotel?
Spa hotels in Palmyra feature on-site spas and offer services like couples massages and a selection of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

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