Photo by Leonardo De Leon

Find Luxury Hotels in Otay Mesa West, CA

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Otay Mesa West Luxury Hotels

Top Otay Mesa West Luxury Hotels

Top Otay Mesa West Hotel Reviews

Bay Club Hotel & Marina

Bay Club Hotel & Marina

10/10 Excellent
"Beautiful "
Tanya 2-night trip
Posted 12 hours ago
Bay Club Hotel & Marina

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Otay Mesa West?
Expedia can help you get a flight to Tijuana Intl. Airport (TIJ) airport or San Diego Intl. Airport (SAN) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Otay Mesa West has to offer.
What's there to see and do in Otay Mesa West?
Experience Otay Mesa West and visit San Diego Zoo, Mission Bay, and San Ysidro Border Crossing. If you have extra time while you're in the area, you might want to see Hotel del Coronado and Petco Park.
How can I get around Otay Mesa West?
It's easier to get around town comfortably when you know your options. Make your way to Iris Avenue Trolley Station for metro transit.