Find Luxury Hotels in Orangeburg, SC

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Our top choices for Orangeburg luxury hotels

Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg
2.0 star property
Orangeburg
8.2 out of 10, Very Good, (1000)
"Enjoyed our stay "
Australia
Marie
The price is NT$2,479
NT$2,752 total
includes taxes & fees
Jan 7 - 2026/1/8
Travelodge by Wyndham Orangeburg

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (640)
"A good option if traveling with pets. The hotel is clean and well maintained but dated. "
United States
Karen
The price is NT$2,196
NT$2,438 total
includes taxes & fees
Jan 5 - 2026/1/6
Red Roof Inn Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1008)
"It was quite and comfortable stay"
United States
Shankar
The price is NT$3,228
NT$3,583 total
includes taxes & fees
Jan 7 - 2026/1/8
Comfort Inn & Suites Santee

Baymont by Wyndham Orangeburg North

Baymont by Wyndham Orangeburg North
2.5 star property
Orangeburg
6.0 out of 10, (1000)
"The room and bathroom need changes,the aspect is very ugly,, "
United States
Vilmarie
The price is NT$1,734
NT$1,925 total
includes taxes & fees
Jan 8 - 2026/1/9
Baymont by Wyndham Orangeburg North

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1416)
"Room was very nice and staff was very nice"
United States
Rupert
The price is NT$2,353
NT$2,612 total
includes taxes & fees
Jan 1 - 2026/1/2
Baymont by Wyndham Santee

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (545)
"The grounds and property were clean and you could tell they take pride in what they're offering."
United States
Eric
The price is NT$2,472
NT$2,744 total
includes taxes & fees
Jan 18 - 2026/1/19
Ramada by Wyndham Santee I-95

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (310)
"Last minute arrangements stay was quiet and peaceful "
United States
Iasia
The price is NT$1,986
NT$2,204 total
includes taxes & fees
Jan 13 - 2026/1/14
Econo Lodge Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Orangeburg

Orangeburgand its attractions for luxury travelers

Orangeburg, South Carolina, offers a charming blend of Southern hospitality and unique experiences for luxury travelers. Begin your journey at the historic Edisto Memorial Gardens, where you can stroll through beautifully manicured landscapes and enjoy a peaceful afternoon by the river. For a taste of local culture, visit the South Carolina State Museum, where you can explore art, history, and science exhibitions that showcase the state's rich heritage. Families will delight in the interactive displays at the Orangeburg County Fine Arts Center, which often features local artists and provides engaging workshops for children. Golf enthusiasts can tee off at the stunning Orangeburg Country Club, known for its pristine greens and welcoming atmosphere. After a day of exploration, unwind at one of the upscale hotels in the downtown area, where modern amenities meet traditional charm, ensuring attentive service and a pampered experience. Enjoy the local dining scene, featuring farm-to-table restaurants that highlight regional flavors, making each meal as memorable as your stay.

Top Orangeburg Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Orangeburg?
Use Expedia and let us help you arrange a flight to Columbia Metropolitan Airport (CAE) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Orangeburg offers. During your visit, you might want to enjoy the sporting events and university which Orangeburg is known for.
When can I expect good weather in Orangeburg?
Planning for the weather is a good way to make your trip to Orangeburg relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 51°F. Average annual precipitation for Orangeburg is 52 inches.
What's there to see and do in Orangeburg?
Experience Orangeburg with a stop at Edisto Memorial Gardens, South Carolina State College Historic District, and Smith-Hammond-Middleton Memorial Center. If you have a little extra time during your trip, you might want to make a stop at Claflin University and South Carolina State University.

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