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Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22
In one month
Dec 4 - Dec 6
In two months
Jan 1 - Jan 3
No exact matches found, but these alternatives could be just right

Recommended hotels in Mill Creek

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

1. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (702 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is NT$3,755
NT$4,236 total
includes taxes & fees
Nov 12 - Nov 13
The Riverview
A spacious lobby with marble flooring, elegant seating, and a grand staircase.

2. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (557 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is NT$3,814
NT$4,322 total
includes taxes & fees
Nov 22 - Nov 23
Courtyard by Marriott Cape Girardeau Downtown
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

3. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is NT$3,129
NT$3,561 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

4. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is NT$2,365
NT$2,668 total
includes taxes & fees
Dec 7 - Dec 8
Pear Tree Inn Cape Girardeau West
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

5. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is NT$3,285
NT$3,706 total
includes taxes & fees
Nov 12 - Nov 13
Drury Plaza Hotel Cape Girardeau Conference Center
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

6. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (240 reviews)
"Great hotel…!!"
United States
Carlos
The price is NT$3,323
NT$3,749 total
includes taxes & fees
Nov 12 - Nov 13
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

7. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, spacious suite, enjoyable kick back and breakfast!"
United States
Mary
The price is NT$2,956
NT$3,335 total
includes taxes & fees
Nov 12 - Nov 13
Drury Inn & Suites Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

8. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (858 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is NT$3,214
NT$3,626 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Cape Girardeau I 55 East
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

9. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.0 out of 10, Good, (819 reviews)
"Clean rooms, nice staff"
United States
Dayanita
The price is NT$1,956
NT$2,207 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cape Girardeau North
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

10. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,000 reviews)
"Nice clean room"
United States
James
The price is NT$2,338
NT$2,819 total
includes taxes & fees
Nov 22 - Nov 23
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

11. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.2 out of 10, (243 reviews)
"Room was clean, bed was comfortable, staff was friendly, parking was easy. It was an older hotel and could use some renovation but would definitely stay again."
United States
Jaime
The price is NT$2,306
NT$2,693 total
includes taxes & fees
Nov 8 - Nov 9
Town House Inn Cape Giradreau
A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.

12. Makanda Inn

Makanda Inn
3.5 star property
Makanda
10.0 out of 10, Exceptional, (41 reviews)
"Makanda inn is a very well maintained place. The room was very comfortable, and the staff was excellent. The breakfasts were delicious."
United States
Thomas
The price is NT$8,605
NT$9,810 total
includes taxes & fees
Nov 16 - Nov 17
Makanda Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top reviews in Mill Creek

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
The Riverview

The Riverview

The Riverview
Cape Girardeau

10/10 Excellent

Very nice place
United States
Mark
Reviewed April 8, 2025
The Riverview

Frequently Asked Questions

What can I expect from a resort vacation in Mill Creek?

Expedia can help you browse resorts and other lodging options that provide similar amenities and comforts. If you have trouble finding a resort in Mill Creek that meets your needs, you can use the search page filters to look for hotels, or search for properties that offer amenities like swimming pools or all-inclusive packages. We make it easy to book great accommodations so you can focus on creating your trip itinerary.

What can I do in Mill Creek?

If you're interested in local sights, Trail of Tears State Park, Century Casino & Hotel Cape Girardeau, and Hunter Valley Winery are some places to visit nearby. Additional attractions in the area include Southeast Missouri State University and Lower Cache River Access Area.

What's the weather like in Mill Creek?

The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 39°F. Average annual precipitation for Mill Creek is 56 inches.

What's the best way to get to and around Mill Creek?

Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 18.9 mi (30.4 km) away from the city center. Otherwise, look for flights into Cairo, IL (CIR-Cairo Regional), which is 19.4 mi (31.3 km) away. If you'd like to explore around the area, consider renting a car to take in more sights.