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Aug 26 - Aug 27
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Our top choices for Lake Issaqueena hotels

An outdoor patio area with a fire pit, seating, and string lights.
A food court with a beverage display, seating area, and a Clemson University sign.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

1. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
5.8 km from Lake Issaqueena
United States
Susana
NT$3,372
NT$3,709 total
includes taxes & fees
Sep 13 - Sep 14
Tru by Hilton Seneca Clemson
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
A hotel lobby with a long corridor, seating areas, and a reception desk.
A brick building with a sign reading "The Inn at Patrick Square".
A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.

2. The Inn at Patrick Square

The Inn at Patrick Square
9.2 km from Lake Issaqueena
United States
Beatriz
NT$4,749
NT$5,271 total
includes taxes & fees
Aug 31 - Sep 1
The Inn at Patrick Square
A white, two-story house with a front porch, surrounded by trees and shrubs.
A bedroom with two beds, a TV, and a fireplace.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A dining area with round tables, black chairs, and white tablecloths.

3. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
13 km from Lake Issaqueena
United States
enrique
NT$3,220
NT$3,574 total
includes taxes & fees
Sep 14 - Sep 15
Liberty Hall Bed and Breakfast
A modern kitchen area with a bar counter and seating.
A modern bar area with high stools and a poolside view.
A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.
A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.

4. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
5.5 km from Lake Issaqueena
United States
DOUGLAS
NT$3,372
NT$3,742 total
includes taxes & fees
Sep 15 - Sep 16
Hampton Inn Clemson-University Area
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
5.6 km from Lake Issaqueena
United States
Laura
NT$3,474
NT$4,313 total
includes taxes & fees
Aug 27 - Aug 28
Lakeside Lodge Clemson
A golf course with a water body, trees, and a distant view of a bridge.
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.
An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.
A golf course with a clubhouse, surrounded by dense trees and a large body of water.

6. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
8.7 km from Lake Issaqueena
United States
Bill
NT$4,749
NT$5,271 total
includes taxes & fees
Sep 1 - Sep 2
Clemson University's James F. Martin Inn
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern lobby with a reception desk, seating area, and a vending machine.

7. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
10.6 km from Lake Issaqueena
United States
Ronald
NT$3,825
NT$4,207 total
includes taxes & fees
Aug 30 - Aug 31
Fairfield Inn & Suites Seneca Clemson Univ Area
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

8. The Abernathy of Clemson

The Abernathy of Clemson
6.7 km from Lake Issaqueena
United States
Robert
NT$4,848
NT$5,381 total
includes taxes & fees
Sep 7 - Sep 8
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

9. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
6.7 km from Lake Issaqueena
United States
Laurrie
NT$7,618
NT$8,456 total
includes taxes & fees
Aug 30 - Aug 31
The Shepherd Hotel Downtown Clemson
A cabin with a large window, surrounded by trees.
A wooden cabin bedroom with a large window, a bed, a bedside table with a lantern, and a heater.
A wooden interior with a table, chair, and a hanging lantern.

10. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
15.8 km from Lake Issaqueena
United States
Nirumol
NT$2,953
NT$4,651 total
includes taxes & fees
Sep 2 - Sep 3
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A modern bar area with a menu board, bar stools, and a countertop with various items.
An outdoor patio with a circular fire pit surrounded by wicker furniture and a pergola overhead.
A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.
A modern dining area with a bar, bar stools, and a patterned rug.

11. Courtyard Marriott Clemson

Courtyard Marriott Clemson
7.3 km from Lake Issaqueena
United States
Gargi
NT$3,766
NT$4,180 total
includes taxes & fees
Sep 1 - Sep 2
Courtyard Marriott Clemson
A modern kitchen with a microwave, coffee maker, and bar stools.
A hotel lobby with a reception desk, a large tiger mural, a TV, and a seating area with a blue sofa.
A hotel room with a large flat-screen TV mounted on the wall, a desk with a chair, a bedside table, a lamp, and a wardrobe.
A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.

12. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
6.6 km from Lake Issaqueena
United States
Anita
NT$3,224
NT$3,579 total
includes taxes & fees
Sep 24 - Sep 25
Comfort Inn & Suites Clemson - University Area

13. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
7.1 km from Lake Issaqueena
NT$3,506
NT$3,892 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express & Suites Clemson by IHG
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A reception area with a counter, chairs, and a patterned rug.
A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

14. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
8.6 km from Lake Issaqueena
United States
Georgina
NT$3,893
NT$4,282 total
includes taxes & fees
Aug 30 - Aug 31
Hampton Inn & Suites Seneca-Clemson Area
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.
A lobby with seating areas, a reception desk, and a patterned wall.

15. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
6.8 km from Lake Issaqueena
United States
Julio
NT$3,224
NT$3,579 total
includes taxes & fees
Aug 28 - Aug 29
Best Western Plus Clemson Hotel & Conference Center
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A wall with a decorative design featuring a building, trees, and a sky with clouds.
A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.

16. Inn @ Clemson

Inn @ Clemson
6.5 km from Lake Issaqueena
United States
Terry
NT$2,553
NT$2,834 total
includes taxes & fees
Aug 27 - Aug 28
Inn @ Clemson
A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.
A bedroom with a bed, bedside tables, a nightstand, a wooden floor, a door, and a wall-mounted shelf.
A cozy living room with a dining table, sofas, and a chandelier.

17. Clemson Memorabilia House

Clemson Memorabilia House
9.3 km from Lake Issaqueena
United States
Ashley
NT$2,837
NT$7,571 total
includes taxes & fees
Aug 27 - Aug 28
Clemson Memorabilia House
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

18. Best Western Seneca-Clemson

Best Western Seneca-Clemson
9.7 km from Lake Issaqueena
United States
Michelle
NT$3,089
NT$3,398 total
includes taxes & fees
Aug 28 - Aug 29
Best Western Seneca-Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

19. Quality Inn Seneca US-123

Quality Inn Seneca US-123
13.5 km from Lake Issaqueena
United States
Anthony
NT$2,410
NT$2,842 total
includes taxes & fees
Sep 3 - Sep 4
Quality Inn Seneca US-123
A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.
A gazebo with a tiled roof and wooden pillars, surrounded by a fence and potted plants.
A gazebo with a tiled roof and a surrounding gravel area.
A hotel room with two beds, a desk, a chair, a TV, and a painting on the wall.

20. Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
7.1 km from Lake Issaqueena
United States
David
NT$2,553
NT$2,834 total
includes taxes & fees
Aug 30 - Aug 31
Days Inn by Wyndham Clemson
View all properties

Compare popular hotels close to Lake Issaqueena

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
An outdoor patio area with a fire pit, seating, and string lights.
Tru by Hilton Seneca Clemson
9.2
Wonderful
880 reviews
View
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
The Inn at Patrick Square
9.8
Exceptional
905 reviews
View
A white, two-story house with a front porch, surrounded by trees and shrubs.
Liberty Hall Bed and Breakfast
10.0
Exceptional
96 reviews
View
A modern kitchen area with a bar counter and seating.
Hampton Inn Clemson-University Area
8.8
Excellent
649 reviews
View
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
Lakeside Lodge Clemson
9.0
Wonderful
1,011 reviews
View

Top Lake Issaqueena Hotel Reviews

The Abernathy of Clemson

The Abernathy of Clemson

10/10 Excellent
"The property was clean and had great access to Clemson University. The staff was very nice accommodating."
Melanie 2-night trip
Posted 1 day ago
The Abernathy of Clemson
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

8/10 Good
"U would of liked it cleaner, especially the kitchen area"
Carol John 4-night trip
Posted 1 day ago
Comfort Inn & Suites Clemson - University Area
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

8/10 Good
"Fair/Decent accommodations."
Monique 1-night trip
Posted 2 days ago
Best Western Plus Clemson Hotel & Conference Center
Courtyard Marriott Clemson

Courtyard Marriott Clemson

10/10 Excellent
"👍"
Nicholas 3-night trip
Posted 4 days ago
Courtyard Marriott Clemson
Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area

8/10 Good
"The hotel rooms need updating, but the hotel is clean, the breakfast is good, and the staff is very friendly."
Rebecca 2-night trip
Posted 8 days ago
Hampton Inn Clemson-University Area

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

8.6/10 (58 reviews)
Larry W. Abernathy Waterfront Park is just one of the places to see in Clemson, so why not enjoy the other things to explore during your travels? Experience the area's theater scene or attend a football game.
See properties

Littlejohn Coliseum

9.4/10 (141 reviews)
Catch an event at Littlejohn Coliseum during your trip to Clemson. Amble around the area's lakeside or attend a football game.
See properties

Sloan Tennis Center

Catch an event at Sloan Tennis Center during your trip to Clemson. You can attend a football game while in the area.
See properties

Memorial Stadium

9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
See properties

Clemson Area African American Museum

You can spend time browsing the exhibits at Clemson Area African American Museum in Clemson. You can attend a football game while in the area.
See properties

Wyndham Plaza

You can browse for the perfect souvenirs at Wyndham Plaza during your visit to Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
See properties

World of Energy

You can spend an afternoon exploring the galleries in World of Energy in Seneca. Amble around this family-friendly area's lakeside or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Lake Issaqueena?
Lake Issaqueena is located in Central. You'll find 206 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay near Lake Issaqueena?
Lakeside Lodge Clemson is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 3.5 mi (5.6 km) from Lake Issaqueena. Other good choices within a few miles include Best Western Plus Clemson Hotel & Conference Center and The Shepherd Hotel Downtown Clemson.
How many hotels are there close to Lake Issaqueena?
Expedia has 206 hotels and other accommodations a few miles from Lake Issaqueena.
If I need to cancel the hotel reservation for my stay near Lake Issaqueena, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to review the top deals on offer near Lake Issaqueena.
Where can I learn more about changing or cancelling my trip in the area near Lake Issaqueena?
For more details about updating your stay near Lake Issaqueena or cancelling it, head over to our customer service page.
What can I see and do near Lake Issaqueena?
You'll want to browse the exhibits at Fort Hill and Clemson Area African American Museum. Explore nature at Keowee Reservoir and Larry W. Abernathy Waterfront Park. If you've got some time to explore the area around Lake Issaqueena, you may want to make a stop by Littlejohn Coliseum, Memorial Stadium, and Sloan Tennis Center.