Find hotels in La Mesa from NT$1,665

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 23 - Dec 24
Tomorrow
Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for La Mesa hotels

Family Quadruple Room | Laptop workspace, soundproofing, free WiFi, bed sheets
B&B Lodgings

B&B Lodgings

B&B Lodgings
2.5 star property
24 de Diciembre
7.8 out of 10, Good, (73)
"Friendly place. Owner cares and it shows. Everything was clean and new."
Mexico
Michael
The price is NT$1,514
NT$1,665 total
includes taxes & fees
Dec 24 - Dec 25
B&B Lodgings
Outdoor pool, pool umbrellas, sun loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
Tocumen
8.4 out of 10, Very Good, (2328)
"Spacious room, clean, good breakfast "
United States
Juan
The price is NT$3,458
NT$4,325 total
includes taxes & fees
Dec 25 - Dec 26
Crowne Plaza Panama Airport by IHG
Exterior
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
Tocumen
9.0 out of 10, Wonderful, (39)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is NT$3,785
NT$4,913 total
includes taxes & fees
Jan 5 - 2026/1/6
ORHO HOTEL BOUTIQUE PANAMA Airport
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1855)
"The room was impeccable, staff was awesome and very professional!!!"
United States
Scott
The price is NT$3,944
NT$4,339 total
includes taxes & fees
Dec 24 - Dec 25
Riande Aeropuerto Hotel & Casino
View from property
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (643)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is NT$7,073
NT$7,781 total
includes taxes & fees
Jan 18 - 2026/1/19
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Apartment, 1 Bedroom, Balcony | Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
Las Mañanitas
The price is NT$2,412
NT$3,024 total
includes taxes & fees
Dec 28 - Dec 29
Swette Love 10 Minutes From the Airport Tocumen
Food and drink
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1004)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is NT$3,458
NT$3,804 total
includes taxes & fees
Jan 8 - 2026/1/9
Courtyard by Marriott Panama Metromall
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (167)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is NT$2,334
NT$4,025 total
includes taxes & fees
Jan 3 - 2026/1/4
Arcadia Condo Suites
Outdoor pool, pool umbrellas, sun loungers
The Westin Panama

The Westin Panama

The Westin Panama
4.0 star property
Costa del Este
9.0 out of 10, Wonderful, (310)
"Great hotel and services"
United States
Pedro
The price is NT$6,754
NT$7,430 total
includes taxes & fees
Jan 10 - 2026/1/11
The Westin Panama
Daily buffet breakfast (PAB 21 per person)
Sheraton Grand Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (994)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is NT$4,230
NT$4,653 total
includes taxes & fees
Jan 9 - 2026/1/10
Sheraton Grand Panama
Breakfast, lunch, dinner served; international cuisine
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1123)
"The hotel is in a great location in Panama. Great amenities excellent breakfast."
United States
Maria
The price is NT$3,088
NT$3,397 total
includes taxes & fees
Jan 10 - 2026/1/11
Ramada Plaza by Wyndham Panama Punta Pacifica
Outdoor pool
Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member
3.0 star property
San Francisco
The price is NT$6,103
NT$6,714 total
includes taxes & fees
Dec 27 - Dec 28
Dovle Residences by HMS-Preferred Member
Exterior
Aloft Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco
8.8 out of 10, Excellent, (896)
"Great staff..warm and welcoming...enjoyed our stay!"
United States
Alystra Marissa Arjoon
The price is NT$3,747
NT$4,122 total
includes taxes & fees
Jan 2 - 2026/1/3
Aloft Panama
Outdoor pool
Boutique Apartments Atlapa

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
7.8 out of 10, Good, (27)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa
Living area
Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
The price is NT$1,412
NT$6,198 total
includes taxes & fees
Jan 11 - 2026/1/12
Living 73 Panamá by Boutique Apartments
Apartment, 3 Bedrooms, Accessible, Pool View | Pool | Outdoor pool
Charming 3 Bedroom Apartment in San Miguelito, Panama City

Charming 3 Bedroom Apartment in San Miguelito, Panama City

Charming 3 Bedroom Apartment in San Miguelito, Panama City
2.0 star property
José Domingo Espinar
The price is NT$2,271
NT$2,498 total
includes taxes & fees
Jan 5 - 2026/1/6
Charming 3 Bedroom Apartment in San Miguelito, Panama City
Apartment | 2 bedrooms
Relaxing 2BR Apt at Coco del mar

Relaxing 2BR Apt at Coco del mar

Relaxing 2BR Apt at Coco del mar
2.0 star property
San Francisco
The price is NT$7,915
NT$8,707 total
includes taxes & fees
Jan 22 - 2026/1/23
Relaxing 2BR Apt at Coco del mar
Apartment (10D) | Balcony
San Francisco by Wynwood House

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is NT$3,917
NT$5,098 total
includes taxes & fees
Jan 12 - 2026/1/13
San Francisco by Wynwood House
Apartment | 2 bedrooms
Lovely 2BR Apt Close to Shops

Lovely 2BR Apt Close to Shops

Lovely 2BR Apt Close to Shops
2.0 star property
San Francisco
The price is NT$7,915
NT$8,707 total
includes taxes & fees
Jan 13 - 2026/1/14
Lovely 2BR Apt Close to Shops
Apartment | 1 bedroom
Elegant 1BR Near Multiplaza

Elegant 1BR Near Multiplaza

Elegant 1BR Near Multiplaza
2.0 star property
San Francisco
Elegant 1BR Near Multiplaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

Arcadia Condo Suites

Arcadia Condo Suites

10/10 Excellent
"Great staff Super clean Decent furniture- a lil flimsy but it worked well Very nice building and felt super comfortable staying here. Tight security at the front desk too. "
Jermaine 1-night trip
Posted 8 days ago
Arcadia Condo Suites

More cheap stays in La Mesa

B&B Lodgings

B&B Lodgings

C. Tercera El Valle de Cerro Azul 24 de Diciembre Panamá Province
The price is NT$1,514 per night from Dec 24 to Dec 25
NT$1,514
NT$1,665 total
Dec 24 - Dec 25
includes taxes & fees
7.8/10 Good! (73 reviews)

Frequently asked questions

Where is the best place to stay in La Mesa?
Crowne Plaza Panama Airport by IHG, located 9.9 mi (15.9 km) from the heart of La Mesa, is a top choice for your stay based on our traveler data. Other good options for your stay in the area are Sheraton Grand Panama and Arcadia Condo Suites. See all available top hotels, or vacation rentals in La Mesa.
If I need to cancel my hotel reservation in La Mesa, will I receive a refund?
Yes, the majority of room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in La Mesa.
Where can I learn more about changing or cancelling my trip to La Mesa?
To access more information about updating your trip to La Mesa or cancelling it, go to https://www.expedia.com/service/.
What is staying in La Mesa like?
Visitors to La Mesa are sure to find plenty to explore and enjoy. There are 444 hotels and other accommodations in the surrounding area. Find out more about La Mesa.
What are the top places to visit in La Mesa?
Places to visit in the wider area include Metromall Panama, Los Pueblos Commercial Center, and Estadio Rommel Fernandez. You'll also find Chagres National Park and Atrio Mall in the area. Check out what more to see and do in Expedia's La Mesa guide.
What's the weather like in La Mesa?
The hottest months are usually April and March with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in La Mesa are July, August, October, and June, with each month seeing an average of 14 inches of rainfall.

Explore a world of travel with Expedia