Find hotels in La Mesa from NT$1,646

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for La Mesa hotels

Crowne Plaza Panama Airport by IHG

4.0 star property
Tocumen
8.4 out of 10, Very Good, (2315)
"The room was clean and the staff were nice! "
United States
CECILIA
The price is NT$3,430
NT$3,773 total
includes taxes & fees
Dec 23 - Dec 24
Crowne Plaza Panama Airport by IHG

ORHO HOTEL BOUTIQUE PANAMA Airport

2.0 star property
Tocumen
8.8 out of 10, Excellent, (35)
"The host was very nice."
United States
Julio
The price is NT$3,742
NT$4,857 total
includes taxes & fees
Dec 11 - Dec 12
ORHO HOTEL BOUTIQUE PANAMA Airport

Riande Aeropuerto Hotel & Casino

4.0 star property
Tocumen
8.6 out of 10, Excellent, (1848)
"Very nice hotel centered around courtyard and pool. Convenient for airport "
Canada
Miles
The price is NT$3,899
NT$4,289 total
includes taxes & fees
Dec 13 - Dec 14
Riande Aeropuerto Hotel & Casino

Aloft Panama

3.5 star property
San Francisco
8.8 out of 10, Excellent, (890)
"The staff was very friendly, rooms were clean and modern."
United States
Greg
The price is NT$3,648
NT$4,013 total
includes taxes & fees
Dec 16 - Dec 17
Aloft Panama

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1006)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is NT$3,154
NT$3,469 total
includes taxes & fees
Jan 5 - 2026/1/6
Courtyard by Marriott Panama Metromall

Express Inn Panama International Airport Hostel

1.5 star property
Tocumen
6.0 out of 10, (655)
"Perfect for a quick overnight before a flight out of PTY or a land and rest location. "
United States
Cecily
The price is NT$1,544
NT$1,698 total
includes taxes & fees
Dec 11 - Dec 12
Express Inn Panama International Airport Hostel

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is NT$7,226
NT$7,949 total
includes taxes & fees
Dec 12 - Dec 13
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1105)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
The price is NT$3,711
NT$4,082 total
includes taxes & fees
Dec 24 - Dec 25
Ramada Plaza by Wyndham Panama Punta Pacifica

Sheraton Grand Panama

4.0 star property
San Francisco
8.6 out of 10, Excellent, (989)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is NT$4,182
NT$4,600 total
includes taxes & fees
Jan 9 - 2026/1/10
Sheraton Grand Panama

The Westin Panama

4.0 star property
Costa del Este
9.0 out of 10, Wonderful, (307)
"Hotel was great and the staff was amazing "
United States
FREDRICK L.
The price is NT$6,141
NT$6,755 total
includes taxes & fees
Dec 12 - Dec 13
The Westin Panama

Arcadia Condo Suites

2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (157)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is NT$1,996
NT$3,636 total
includes taxes & fees
Dec 15 - Dec 16
Arcadia Condo Suites

Boutique Apartments Atlapa

3.0 star property
San Francisco
8.0 out of 10, Very Good, (26)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa

Boutique Apartments Panamá Coco del Mar

3.5 star property
San Francisco
7.4 out of 10, Good, (152)
"Clean room good place to stay "
United States
Gideon
The price is NT$1,374
NT$5,883 total
includes taxes & fees
Dec 11 - Dec 12
Boutique Apartments Panamá Coco del Mar

B&B Lodgings

2.5 star property
24 de Diciembre
7.8 out of 10, Good, (70)
"I givethis rating of five stars because Daisy the owner, is so wonderful. I ended up checking in late. She helped me order food. She was very very accommodating. Her English is very good. The room that I stayed in was very clean and had everything that you would need. I will stay there again When I will have to stay in Panama City. The grounds are absolutely beautiful."
United States
Stephanie
The price is NT$1,497
NT$1,646 total
includes taxes & fees
Dec 11 - Dec 12
B&B Lodgings

San Francisco by Wynwood House

3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is NT$4,378
NT$5,595 total
includes taxes & fees
Dec 11 - Dec 12
San Francisco by Wynwood House

Dovle Residences by HMS-Preferred Member

3.0 star property
San Francisco
The price is NT$6,104
NT$6,714 total
includes taxes & fees
Dec 11 - Dec 12
Dovle Residences by HMS-Preferred Member

Swette Love 10 Minutes From the Airport Tocumen

2.0 star property
Las Mañanitas
The price is NT$2,357
NT$2,955 total
includes taxes & fees
Dec 25 - Dec 26
Swette Love 10 Minutes From the Airport Tocumen

Living 73 Panamá by Boutique Apartments

3.0 star property
San Francisco
The price is NT$1,293
NT$6,005 total
includes taxes & fees
Dec 22 - Dec 23
Living 73 Panamá by Boutique Apartments

Charming 3 Bedroom Apartment in San Miguelito, Panama City

2.0 star property
José Domingo Espinar
The price is NT$2,219
NT$2,441 total
includes taxes & fees
Dec 11 - Dec 12
Charming 3 Bedroom Apartment in San Miguelito, Panama City

w Bright 1BR w Private Balcony in San Francisco

2.0 star property
San Francisco
The price is NT$2,539
NT$3,719 total
includes taxes & fees
Dec 13 - Dec 14
w Bright 1BR w Private Balcony in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top La Mesa Hotel Reviews

More cheap stays in La Mesa

Frequently asked questions

Where is the best place to stay in La Mesa?
Crowne Plaza Panama Airport by IHG, located 9.9 mi (15.9 km) from the heart of La Mesa, is a top choice for your stay based on our traveler data. Other good options for your stay in the area are Sheraton Grand Panama and Arcadia Condo Suites. See all available top hotels, or vacation rentals in La Mesa.
If I need to cancel my hotel reservation in La Mesa, will I receive a refund?
Yes, the majority of room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in La Mesa.
Where can I learn more about changing or cancelling my trip to La Mesa?
To access more information about updating your trip to La Mesa or cancelling it, go to https://www.expedia.com/service/.
What is staying in La Mesa like?
Visitors to La Mesa are sure to find plenty to explore and enjoy. There are 386 hotels and other accommodations in the surrounding area. Find out more about La Mesa.
What are the top places to visit in La Mesa?
Places to visit in the wider area include Metromall Panama, Los Pueblos Commercial Center, and Estadio Rommel Fernandez. You'll also find Chagres National Park and Chepo Youth Recreation Center in the area. Check out what more to see and do in Expedia's La Mesa guide.
What's the weather like in La Mesa?
The hottest months are usually April and March with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in La Mesa are July, August, October, and June, with each month seeing an average of 14 inches of rainfall.

Explore a world of travel with Expedia