Jefferson County Vacations & Trips

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    Save up to NT$5,067 when you book a flight and hotel together*

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Top destinations in Jefferson County

A nighttime smartphone photo on the W Main Street overpass on Hwy 1-55.
FlightsFlightsHotelsHotels

Festus

Festus
The cruise ship I was on took more than 7 hours to navigate the Mississippi River before getting out to the open sea, the Gulf of Mexico.
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Imperial

Imperial

Jefferson County Hotel Deals

21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is NT$4,216 per night from Feb 23 to Feb 24
NT$4,216
NT$5,087 total
Feb 23 - Feb 24
includes taxes & fees
9/10 Wonderful! (1,612 reviews)
Pleasant staff

Reviewed on 2026/2/17

21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
The price is NT$3,285 per night from Feb 26 to Feb 27
NT$3,285
NT$3,834 total
Feb 26 - Feb 27
includes taxes & fees
8.8/10 Excellent! (3,095 reviews)
For the price you really can't ask for much more. Good breakfast, clean rooms, great showers, friendly staff. My only small criticisms are that there i

Reviewed on 2026/2/17

Clayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
The price is NT$2,821 per night from Feb 24 to Feb 25
NT$2,821
NT$3,321 total
Feb 24 - Feb 25
includes taxes & fees
9.4/10 Exceptional! (2,835 reviews)
We felt very welcome when we arrived and were invited to some popcorn and soda as an evening snack. Our room was spotless and comfortable. The breakfast was delicious, hot, and a terrific way to begin our day of travel.

Reviewed on 2026/2/17

Pear Tree Inn St. Louis Airport
See all 1,984 properties in Jefferson County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Jefferson County vacation package cost?
Our Jefferson County packages, which begin at just , are the perfect way to save money. Select your favorite hotels, flights and more to create a customized trip.
How do I get a cheap travel package to Jefferson County?
Combine your hotel and flight bookings, add on extras such as tours, and save with a Jefferson County vacation package. You won't just pick up exciting discounts on your escape — you'll have plenty of choice within your reach too. When you book through Expedia, you'll have your pick of over 550 air carriers and 1,000,000 properties globally. Your affordable vacation begins right here, right now!
What are the top hotels in Jefferson County?
For hotels in De Soto with cozy beds and friendly service, you can't go past Pear Tree Inn St. Louis Arnold and Quality Inn & Suites Arnold - St Louis. If you plan to visit Festus as well, you'll get a great night's sleep at Comfort Inn Festus - St Louis South or La Quinta Inn & Suites by Wyndham Festus - St. Louis South.
How far in advance should I book my Jefferson County vacation?
Travelers are generally able to compare international airfares on Expedia within 12 months of the departure date. Booking at the last minute? With a stroke of luck, it's still possible to purchase a cheaper ticket just weeks before your journey.
What does an Expedia Jefferson County travel package include?
Select from a combination of hotels, rental cars and flights. Once you've made your booking, you can also add on experiences and activities. Want to pick your fare class? That's easy to do too. The choice is all yours when it comes to planning your ideal Jefferson County trip.
What should I know before booking a Jefferson County travel package?
When you book your hotels, flights and car rentals together, you'll be rewarded with terrific discounts. Whether you're organizing a beach break in a villa or prefer to stay in a ritzy city hotel, Expedia will make it happen for less.
Can I choose my airline with a Jefferson County Expedia vacation package?
You can, and with over 550 airlines to select from across the globe, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Jefferson County vacation package?
Your situation can change without warning, so yes. You may be able to cancel or alter your Jefferson County vacation package at no cost if you've booked in the last 24 hours. For older bookings, you can still cancel or make changes, but your airline, hotel or car rental company may charge a fee. Need more information? Check out our Customer Service Portal. We'll help make sure your trip goes off without a hitch.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.