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Our top choices for Isle of Palms hotels

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (472 reviews)
"Great stay! Clean room, friendly staff. "
United States
Sabrena
The price is NT$4,948
NT$5,616 total
includes taxes & fees
Apr 5 - Apr 6
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Weekly Inn

Weekly Inn
2.0 star property
14.9 km from Isle of Palms
7.6 out of 10, Good, (1,165 reviews)
"Always a nice stay. cool florida vibe. "
United States
Matthew
Weekly Inn

Home2 Suites By Hilton Jacksonville Downtown

Home2 Suites By Hilton Jacksonville Downtown
3.0 star property
24.4 km from Isle of Palms
9.2 out of 10, Wonderful, (297 reviews)
"The room was very clean, the staff very friendly, everything was great! "
United States
Starla
The price is NT$4,031
NT$4,575 total
includes taxes & fees
Mar 29 - Mar 30
Home2 Suites By Hilton Jacksonville Downtown

Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.7 km from Isle of Palms
8.8 out of 10, Excellent, (652 reviews)
"Great hotel "
United States
Jameida
The price is NT$4,589
NT$5,934 total
includes taxes & fees
Mar 25 - Mar 26
Seahorse Oceanfront Inn

Holiday Inn Express Jacksonville - Blount Island by IHG

Holiday Inn Express Jacksonville - Blount Island by IHG
2.5 star property
20.3 km from Isle of Palms
8.8 out of 10, Excellent, (1,001 reviews)
"Staff was incredibly friendly, breakfast was great, nice location."
United States
Melissa
The price is NT$3,364
NT$3,818 total
includes taxes & fees
Mar 24 - Mar 25
Holiday Inn Express Jacksonville - Blount Island by IHG

Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport
2.5 star property
30.8 km from Isle of Palms
8.8 out of 10, Excellent, (297 reviews)
"Great place for the price."
United States
Cliff
The price is NT$3,016
NT$3,423 total
includes taxes & fees
Mar 29 - Mar 30
Extended Stay America Premier Suites - Jacksonville - Airport

Midtown Lodge

Midtown Lodge
2.5 star property
19.1 km from Isle of Palms
8.0 out of 10, Very Good, (613 reviews)
"The cleanness and the bedding was superb. The staff nice and welcoming too."
United States
Assan
The price is NT$1,991
NT$2,259 total
includes taxes & fees
Mar 19 - Mar 20
Midtown Lodge

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
9.7 km from Isle of Palms
9.6 out of 10, Exceptional, (89 reviews)
"Loved the staff, the cleanliness, and the food was excellent. Really enjoyed my stay here!!"
United States
Toni
The price is NT$3,990
NT$4,529 total
includes taxes & fees
Apr 5 - Apr 6
TownePlace Suites by Marriott® Jacksonville Mayport

Hampton Inn Jacksonville East Regency Square

Hampton Inn Jacksonville East Regency Square
2.5 star property
13 km from Isle of Palms
8.6 out of 10, Excellent, (1,001 reviews)
"We stay here every time we visit family, very convenient, clea, friendly and quiet. "
United States
Robin
The price is NT$2,647
NT$3,004 total
includes taxes & fees
Apr 7 - Apr 8
Hampton Inn Jacksonville East Regency Square

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
9.1 km from Isle of Palms
9.4 out of 10, Exceptional, (184 reviews)
"Staff was excellent...highly recommend this Hotel"
Canada
Robert
The price is NT$6,671
NT$7,572 total
includes taxes & fees
Apr 17 - Apr 18
AC Hotel Jacksonville St Johns Town Center

San Marco Inn East

San Marco Inn East
3.0 star property
19.7 km from Isle of Palms
8.4 out of 10, Very Good, (1,392 reviews)
"Can't beat it. Great place to stay. Very clean and well maintained. This is where I will stay on my next trip to Jacksonville. "
United States
Frank
The price is NT$2,441
NT$2,770 total
includes taxes & fees
Mar 22 - Mar 23
San Marco Inn East

Tricove Inn & Suites

Tricove Inn & Suites
2.5 star property
16 km from Isle of Palms
7.2 out of 10, Good, (1,001 reviews)
"Staff very friendly and coffee hot"
United States
Frederick
Tricove Inn & Suites

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
2.1 km from Isle of Palms
9.4 out of 10, Exceptional, (176 reviews)
"Great place to stay"
United States
Judy
The price is NT$5,549
NT$6,298 total
includes taxes & fees
Apr 4 - Apr 5
Hilton Jacksonville At Mayo Clinic

Tru by Hilton Jacksonville Airport I-95

Tru by Hilton Jacksonville Airport I-95
2.5 star property
31.5 km from Isle of Palms
9.4 out of 10, Exceptional, (977 reviews)
"Great staff good food "
United States
Slavik
The price is NT$3,495
NT$3,966 total
includes taxes & fees
Apr 5 - Apr 6
Tru by Hilton Jacksonville Airport I-95

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.9 km from Isle of Palms
8.8 out of 10, Excellent, (1,003 reviews)
"The staff was very friendly and knowledgeable and the morning breakfast was very good. Will be staying again in the future "
United States
Kimberly
The price is NT$3,575
NT$4,058 total
includes taxes & fees
Mar 22 - Mar 23
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Baymont by Wyndham Jacksonville/Butler Blvd

Baymont by Wyndham Jacksonville/Butler Blvd
2.5 star property
16.4 km from Isle of Palms
8.2 out of 10, Very Good, (1,358 reviews)
"Beautiful and clean to stay ✨️ "
United States
Lean
The price is NT$2,334
NT$2,649 total
includes taxes & fees
Apr 1 - Apr 2
Baymont by Wyndham Jacksonville/Butler Blvd

Wyndham Garden Jacksonville

Wyndham Garden Jacksonville
3.0 star property
15.5 km from Isle of Palms
7.8 out of 10, Good, (1,821 reviews)
"Excellent accommodations"
United States
Richard
The price is NT$2,686
NT$3,049 total
includes taxes & fees
Mar 26 - Mar 27
Wyndham Garden Jacksonville

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,000 reviews)
"Great location, breakfast was delicious "
United States
Paul
The price is NT$4,494
NT$5,101 total
includes taxes & fees
Apr 13 - Apr 14
Best Western Oceanfront

Hampton Inn Suites Jacksonville Airport

Hampton Inn Suites Jacksonville Airport
2.5 star property
31.6 km from Isle of Palms
8.6 out of 10, Excellent, (1,000 reviews)
"Staff friendly and service amazing "
United States
Deborah L
The price is NT$2,722
NT$3,090 total
includes taxes & fees
Apr 5 - Apr 6
Hampton Inn Suites Jacksonville Airport

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (3,749 reviews)
"Nice spot, friendly staff, nice bar and great beach location. "
United States
Keith
The price is NT$5,430
NT$6,163 total
includes taxes & fees
Apr 12 - Apr 13
Margaritaville Jacksonville Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Downtown Jacksonville

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

Sawgrass

Visitors to Sawgrass like its beaches and riverfront, and Mickler Beach is a sight worth a stop.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms Hotel Reviews

Frequently asked questions

What is Isle of Palms like?
Travelers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighborhood.
What's a favorite place to stay in Isle of Palms?
Based on Expedia customer reviews, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is the highest ranked property in Isle of Palms. This hotel offers free breakfast and an outdoor pool.
How many hotels can I expect to find in Isle of Palms?
Expedia has 43 hotels and other accommodations in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes, you'll find most hotel reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Isle of Palms.
Where can I learn more about changing or cancelling my trip to Isle of Palms?
For more information about changing or cancelling your trip to Isle of Palms, head over to our customer service page.
What is there to do in this Jacksonville Beach neighborhood?
A few places to visit in the area around Isle of Palms include Cradle Creek Preserve, Jacksonville Beach Golf Club, and Windsor Parke Golf Club. While you're out sightseeing in Jacksonville Beach, be sure to visit other sights like Players by the Sea or Rhoda Martin Cultural Heritage Center.

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