Find Resorts & Hotels with Spas in Isernia

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 7 - Nov 8
Tomorrow
Nov 8 - Nov 9
Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22

Our top choices for Isernia hotels with a spa

A modern bathroom with a large bathtub, wooden flooring, and a glass shower enclosure.

1. Fonte Del Benessere Resort Castelpetroso - Molise

Fonte Del Benessere Resort Castelpetroso - Molise
5.0 star property
Castelpetroso
10.0 out of 10, Exceptional, (23 reviews)
  • cleanliness
    Unwind in a tranquil retreat with 6 treatment rooms and couples services at this luxury spa hotel.
The price is NT$6,956
NT$7,651 total
includes taxes & fees
Nov 11 - Nov 12
Fonte Del Benessere Resort Castelpetroso - Molise
A rooftop pool with glass railings, a city view, and a textured wall.

2. Domus Hotel

Domus Hotel
4.0 star property
Bagnoli del Trigno
9.2 out of 10, Wonderful, (60 reviews)
  • cleanliness
    Escape to a serene wellness sanctuary with 4 spa treatment rooms, hot springs, and a seasonal outdoor pool in a tranquil setting.
The price is NT$3,827
NT$4,210 total
includes taxes & fees
Nov 9 - Nov 10
Domus Hotel
A modern lobby with a stone wall, a fireplace, seating area, and a large potted plant.

3. Sport Village Hotel & Spa

Sport Village Hotel & Spa
4.0 star property
Castel di Sangro
8.8 out of 10, Excellent, (51 reviews)
The price is NT$3,540
NT$3,894 total
includes taxes & fees
Nov 29 - Nov 30
Sport Village Hotel & Spa
A grand staircase with marble steps and ornate railings, leading to an upper level with a balcony.

4. Dimora del Prete di Belmonte - Bed & Breakfast

Dimora del Prete di Belmonte - Bed & Breakfast
Venafro
9.8 out of 10, Exceptional, (36 reviews)
  • cleanliness
    Rejuvenate with in-room massages at this historic affittacamere, featuring a tranquil garden and rooftop terrace near Pandone Castle.
The price is NT$3,994
NT$4,393 total
includes taxes & fees
Nov 9 - Nov 10
Dimora del Prete di Belmonte - Bed & Breakfast
A modern indoor pool area with lounge chairs, a stone pillar, and a glass-enclosed spa area.

5. Borgotufi Albergo Diffuso

Borgotufi Albergo Diffuso
Castel del Giudice
9.0 out of 10, Wonderful, (34 reviews)
  • cleanliness
    Mountain retreat offers daily sports, Swedish massages, and full-service spa with sauna and hot tub.
The price is NT$5,302
NT$5,832 total
includes taxes & fees
Nov 13 - Nov 14
Borgotufi Albergo Diffuso
A two-story house with a garden, a stone archway, and a well-lit entrance.

6. Hotel Des Reves - Al Poggio di Casalucense

Hotel Des Reves - Al Poggio di Casalucense
4.0 star property
Sant'Elia Fiumerapido
9.2 out of 10, Wonderful, (42 reviews)
  • cleanliness
    Luxurious mountain retreat with full-service spa and winery offers daily massages and garden serenity.
The price is NT$2,845
NT$3,130 total
includes taxes & fees
Nov 30 - Dec 1
Hotel Des Reves - Al Poggio di Casalucense
A spa room with multiple massage chairs and a wall-mounted fire feature.

7. 5 Miglia Hotel & SPA

5 Miglia Hotel & SPA
3.0 star property
Rivisondoli
8.2 out of 10, Very good, (59 reviews)
  • cleanliness
    Relax in a mountain retreat with soothing spa treatments, an indoor pool, and hot tub for a complete wellness escape at this hotel.
The price is NT$4,060
NT$4,466 total
includes taxes & fees
Dec 8 - Dec 9
5 Miglia Hotel & SPA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Isernia

Pool
Breakfast included

Top Isernia Hotel Reviews

A grand staircase with marble steps and ornate railings, leading to an upper level with a balcony.
Dimora del Prete di Belmonte - Bed & Breakfast

Dimora del Prete di Belmonte - Bed & Breakfast

Dimora del Prete di Belmonte - Bed & Breakfast
Venafro

10/10 Excellent

This palace is a dream, beautifully appointed, stunning views and Dorothy, the owner, felt like an old friend. I wanted to stay so much longer. Only improvement would have been directions or signage on how to find the grand abode. Once found, parking was available right out front on the street, a safe street.
United States
Paula
Reviewed May 8, 2026
Dimora del Prete di Belmonte - Bed & Breakfast

Frequently Asked Questions

Looking for a spa hotel in Isernia?

Treat yourself to some time in a luxurious spa hotel and you won't regret it. Be sure to pay a visit to the monuments during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your holiday.

What is the best spa hotel in Isernia?

Moon Resort & Spa is a top spa hotel featuring a bar and an indoor pool. Treat yourself to a facial, couples treatments, or massage at the onsite spa.

How many spa hotels will I find in Isernia?

Among Expedia's 14 accommodation options in Isernia, there is 1 spa hotel.

What's there to see and do in Isernia?

Enjoy Isernia with a stop at National Museum of the Paleolithic, Cipresseta di Fontegreca, and Lago di Castel San Vincenzo. If you have extra time while you're in the area, you might want to stop by Campitello Matese Ski Resort and Matese massif.

What is a Isernia spa hotel?

Spa hotels in Isernia provide lodging and have an on-site spa offering services such as couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.