Photo by Visit Greenville, South Carolina

Find Boutique Hotels in Greenville, SC

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Boutique Hotels

Tonight
Dec 24 - Dec 25
Tomorrow
Dec 25 - Dec 26
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Greenville boutique hotels

Bar (on property)
Hotel Domestique

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is NT$8,647
NT$9,512 total
includes taxes & fees
Jan 18 - 2026/1/19
Hotel Domestique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Greenville Hotel Reviews

Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

10/10 Excellent
"Great staff, very helpful, fantastic beds and breakfast."
Elizabeth 1-night trip
Posted 4 days ago
Hyatt Place Greenville/Haywood

Frequently asked questions

What's there to see and do in Greenville?
The shopping, waterfalls, and sporting events are just some of the things to enjoy while you're in the area. Activities and attractions to experience around Greenville include The Peace Center, Roper Mountain Science Center, and Alchemy Comedy Theater. For even more to see and do, make a stop at The Children's Museum of the Upstate, Bon Secours Wellness Arena, and Greenville Zoo.
What kind of weather should I plan for when I travel to Greenville?
Understanding the weather in Greenville is important when you plan your trip. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Greenville is 55 inches.
What's the best way to get to my boutique hotel in Greenville?
You have a few options for transportation to and around Greenville. The nearest major airport is Greenville-Spartanburg Intl. Airport (GSP), which is located 10.7 mi (17.2 km) from the heart of the city. If you want to explore the larger area, ride aboard one of the trains from Greenville Station.

Explore a world of travel with Expedia