A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find Adults Only Resorts & Hotels in Florida Keys

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys Adults Only Resorts & Hotels

Tonight
Oct 19 - Oct 20
Tomorrow
Oct 20 - Oct 21
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Florida Keys adults-only hotels

A view through a window with metal bars, featuring a beach with palm trees, a thatched umbrella, and a wooden dock.
A tropical resort with a paved pathway leading to a building, surrounded by palm trees and lush greenery.
A beach with kayaks lined up near the water's edge, palm trees, and lounge chairs.
A clear blue pool surrounded by palm trees and a thatched-roof structure, with a sign indicating no diving.

1. Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
Rock Harbor
United States
Billy
NT$5,205
NT$6,767 total
includes taxes & fees
Oct 20 - Oct 21
Kona Kai Resort and Gallery - Adults Only
A poolside area with lounge chairs, a staircase leading to a balcony, and a pool.
A beige sofa with two pillows, flanked by two wooden side tables with lamps and potted plants, against a white wall with a framed picture of a tree.
An outdoor patio with tables and chairs, surrounded by trees and a house.
A dining area with round tables and wicker chairs, a ceiling fan, and a bar area in the background.

2. The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only
Old Town Key West
United States
Anthony
NT$4,180
NT$6,160 total
includes taxes & fees
Oct 25 - Oct 26
The Southernmost Inn - Adults Only
A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.
A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.
A lush garden with a variety of tropical plants and a paved walkway.
A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

3. Duval House

Duval House
Old Town Key West
United States
Cathrine
NT$5,476
NT$6,857 total
includes taxes & fees
Oct 25 - Oct 26
Duval House
A large, ornate hotel with a pool, palm trees, and a view of the ocean.
A large, two-story house with a prominent tower and a covered porch.
A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.
A grand staircase with ornate railings and a chandelier.

4. Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
Old Town Key West
United States
Amy
NT$5,803
NT$10,629 total
includes taxes & fees
Oct 25 - Oct 26
Southernmost House - Adult Exclusive
A tropical outdoor area with palm trees, hanging plants, and string lights.
A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.
A large, two-story building with a balcony, surrounded by dense tropical foliage.
A wooden deck with lush greenery and a pool area.

5. Douglas House - Adults Only

Douglas House - Adults Only
Old Town Key West
United States
Maricela
NT$5,100
NT$6,311 total
includes taxes & fees
Oct 27 - Oct 28
Douglas House - Adults Only
A spacious room with a wooden floor, white furniture, and large windows.
A white building with a covered porch, potted plants, and a white picket fence.
A paved pathway surrounded by lush greenery and palm trees.
A modern living room with a sofa, two armchairs, a coffee table, and a small table with a lamp. There is a large window with shutters, an air conditioning unit, and a view of greenery outside.

6. Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only
Old Town Key West
United States
Meghan
NT$4,013
NT$6,108 total
includes taxes & fees
Oct 27 - Oct 28
Paradise Inn Key West - Adults Only
A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.
A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.
A row of blue bicycles parked under a tree, with a white fence and a building in the background.
A covered outdoor area with a wooden staircase, seating, and potted plants.

7. The Grand Guesthouse

The Grand Guesthouse
Old Town Key West
United States
Justyn
NT$5,099
NT$6,547 total
includes taxes & fees
Oct 27 - Oct 28
The Grand Guesthouse
A wooden deck with wicker furniture, a white staircase, and a lush garden area.
A hotel room with a large bed, a view of a swimming pool, and a balcony with outdoor seating.
A hotel entrance with a sign reading "Heron House Office."
A two-story house with a balcony, surrounded by palm trees and a clear blue sky.

8. Heron House - Adult Only

Heron House - Adult Only
Old Town Key West
United States
Lance
NT$5,150
NT$6,911 total
includes taxes & fees
Oct 25 - Oct 26
Heron House - Adult Only
A pool area with palm trees and a building with a white roof.
A spacious interior with a central open area, a balcony with a railing, and a tiled floor.
A wooden deck overlooking clear turquoise water with a backdrop of dense green foliage and a clear blue sky.
A coastal scene with rocky shores, a wooden pier, and calm water.

9. Bahia Bay Resort

Bahia Bay Resort
Rock Harbor
United States
Ben
NT$4,928
NT$5,544 total
includes taxes & fees
Oct 20 - Oct 21
Bahia Bay Resort
A breakfast setup with wine bottles, fruits, and pastries on a tray by a door with a view of a staircase and greenery.
A white building with a grey roof, surrounded by potted plants and a blue umbrella.
A patio with sun loungers, a table with an umbrella, and potted plants.
A spacious kitchen with wooden cabinets and a dining area with a round table and chairs.

10. The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only
Old Town Key West
United States
Donna
NT$5,220
NT$7,330 total
includes taxes & fees
Oct 25 - Oct 26
The Cabana Inn Key West - Adults Only
View all properties

Top Florida Keys Hotel Reviews

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

10/10 Excellent
"clean room and very unique location. The breakfast was just ok and overpriced"
Anna 1-night trip
Posted 5 hours ago
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Hawks Cay Resort

Hawks Cay Resort

8/10 Good
"Our villa was right next to the workers building. Not an ideal spot for a “premium” villa. Also when they were cutting lawn and blowing leaves they were blowing everything all over our rental cars. Parking was tough because I think employees were also parking in guest spots. Again I think this was due to the location of our villa. We were never told what to do with our garbage or if housekeeping would come clean. Found out later you need to specifically request it 24 hrs in advance. It was off season so nice and quite not too many people so they definitely could have put us elsewhere. Other than that we really enjoyed ourselves and plan to go back next time we would just be specific on check in about the location they put us in."
Tamara 7-night trip
Posted 14 hours ago
Hawks Cay Resort

Explore a world of travel with Expedia