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Find Boutique Hotels in Cincinnati Central Business District, OH

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Check availability on Cincinnati Central Business District Boutique Hotels

Our top choices for Cincinnati Central Business District boutique hotels

Egyptian cotton sheets, premium bedding, in-room safe, laptop workspace
21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

4.5 star property
Downtown Cincinnati
8.6 out of 10, Excellent, (1007)
"Very clean rooms, great bar, friendly staff."
United States
Theodore
The price is NT$4,487
NT$5,510 total
includes taxes & fees
Jan 2 - 2026/1/3
21c Museum Hotel Cincinnati
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cincinnati Central Business District Hotel Reviews

Renaissance Cincinnati Downtown Hotel

Renaissance Cincinnati Downtown Hotel

10/10 Excellent
"great staff, easy to walk to attractions"
Gary 3-night trip
Posted 4 days ago
Renaissance Cincinnati Downtown Hotel

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Frequently asked questions

What's the best boutique hotel in Cincinnati Central Business District?
21c Museum Hotel Cincinnati is a favorite hotel with Expedia travelers looking for a stylish stay, and features a full-service spa and massages.
What's there to see and do in Cincinnati Central Business District?
Once you've decided where you'd like to stay, plan what to do for fun on your vacation. Attractions and activities to experience around Cincinnati Central Business District include Taft Theatre, Fountain Square, and Aronoff Center for the Arts. While you're here, you might also like to explore more of the area and take in additional sights like Cincinnati Reds Hall of Fame and Museum, National Underground Railroad Freedom Center, and Great American Ball Park.
What's the best way to get to my boutique hotel in Cincinnati Central Business District?
You have a few options for transportation to and around Cincinnati Central Business District. The closest major airport is Cincinnati, OH (LUK-Cincinnati Municipal - Lunken Field), which is located 4.3 mi (7 km) away, but Cincinnati-Northern Kentucky Int'l Airport (CVG) may also be an option. Take advantage of metro transit at 247 Telemarketing Tram Stop, Fountain Square Tram Stop, and Richter & Phillips Tram Stop.