Lodging Image

Find hotels in Cherokee Seneca, Louisville

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Cherokee Seneca hotels

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

1. Holiday Inn Express Louisville Airport Expo Center by IHG

Holiday Inn Express Louisville Airport Expo Center by IHG
2.5 star property
4 km from Cherokee Seneca
8.6 out of 10, Excellent, (1,004 reviews)
"nice clean place and a good free breakfast is a +"
United States
Cliff
The price is NT$2,963
NT$3,486 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express Louisville Airport Expo Center by IHG
A modern dining area with multiple tables and chairs, a kitchen area with stainless steel appliances, and a large window with blue curtains.

2. Wingate by Wyndham Louisville Fair and Expo

Wingate by Wyndham Louisville Fair and Expo
3.0 star property
3.7 km from Cherokee Seneca
8.4 out of 10, Very good, (1,233 reviews)
"Clean room, hot breakfast, good staff."
United States
Grace
The price is NT$2,221
NT$2,613 total
includes taxes & fees
Oct 25 - Oct 26
Wingate by Wyndham Louisville Fair and Expo
A Hilton Garden Inn hotel with a modern design, multiple floors, and a well-lit entrance.

3. Hilton Garden Inn Louisville Mall of St. Matthews

Hilton Garden Inn Louisville Mall of St. Matthews
3.0 star property
St. Matthews, 5.2 km from Cherokee Seneca
9.2 out of 10, Wonderful, (1,002 reviews)
"Great location, clean and tidy room"
United States
Michael
The price is NT$2,978
NT$3,504 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Garden Inn Louisville Mall of St. Matthews
A Courtyard by Marriott hotel with a modern facade, multiple floors, and a well-lit entrance.

4. Courtyard by Marriott Louisville Airport

Courtyard by Marriott Louisville Airport
3.0 star property
7.1 km from Cherokee Seneca
9.2 out of 10, Wonderful, (473 reviews)
"nice place great staff"
United States
SHEILA
The price is NT$2,839
NT$3,340 total
includes taxes & fees
Oct 4 - Oct 5
Courtyard by Marriott Louisville Airport
A bar area with multiple seating options and a large display of liquor bottles.

5. Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)
4.0 star property
6 km from Cherokee Seneca
9.4 out of 10, Exceptional, (2,537 reviews)
"Rooms was spacious, clean, staff was helpful, would recommend others"
United States
Eddie
The price is NT$3,223
NT$3,792 total
includes taxes & fees
Oct 5 - Oct 6
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)
A grand lobby with ornate columns, plush seating, and a chandelier.

6. The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
9.4 out of 10, Exceptional, (1,330 reviews)
"Great stay"
United States
Meghan
The price is NT$4,277
NT$5,032 total
includes taxes & fees
Oct 25 - Oct 26
The Brown Hotel
An indoor swimming pool with lounge chairs and umbrellas, surrounded by arched windows and a tiled floor.

7. Hawthorn Suites by Wyndham Louisville East

Hawthorn Suites by Wyndham Louisville East
3.0 star property
St. Matthews, 5.2 km from Cherokee Seneca
8.6 out of 10, Excellent, (1,120 reviews)
"Nice property. Enjoyed our stay."
United States
Lucia
The price is NT$2,586
NT$3,043 total
includes taxes & fees
Nov 1 - Nov 2
Hawthorn Suites by Wyndham Louisville East
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

8. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 6.5 km from Cherokee Seneca
9.0 out of 10, Wonderful, (4,332 reviews)
"Great place to stay at"
United States
Saud
The price is NT$4,624
NT$5,441 total
includes taxes & fees
Oct 25 - Oct 26
Galt House Hotel Trademark Collection by Wyndham
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

9. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,372 reviews)
"Great location clean hotel and friendly staff."
United States
Maurica
The price is NT$4,677
NT$5,502 total
includes taxes & fees
Oct 29 - Oct 30
Embassy Suites Louisville Downtown
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

10. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 4.9 km from Cherokee Seneca
9.4 out of 10, Exceptional, (1,131 reviews)
"Great stay!"
United States
Addison
The price is NT$3,893
NT$4,580 total
includes taxes & fees
Oct 4 - Oct 5
Tempo By Hilton Louisville Downtown Nulu
A modern lobby with a curved reception desk, seating area with sofas and armchairs, and a central coffee table.

11. Springhill Suites by Marriott Louisville Airport

Springhill Suites by Marriott Louisville Airport
3.0 star property
Fairgrounds, 7.1 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,003 reviews)
"Friendly helpful staff. Clean spacious room."
United States
Gale
The price is NT$2,804
NT$3,299 total
includes taxes & fees
Oct 25 - Oct 26
Springhill Suites by Marriott Louisville Airport
A hotel corridor with a snack bar, refrigerated display, and a long hallway with a patterned carpet.

12. Hampton Inn Louisville-Airport

Hampton Inn Louisville-Airport
2.5 star property
Fairgrounds, 7.2 km from Cherokee Seneca
8.6 out of 10, Excellent, (1,001 reviews)
"Great Stay"
United States
Amanda
The price is NT$3,057
NT$3,597 total
includes taxes & fees
Oct 12 - Oct 13
Hampton Inn Louisville-Airport
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

13. Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 6.2 km from Cherokee Seneca
9.4 out of 10, Exceptional, (2,163 reviews)
"This was the perfect location and wonderful place to stay"
United States
Samantha
The price is NT$8,093
NT$9,522 total
includes taxes & fees
Oct 30 - Oct 31
Omni Louisville Hotel
A reception desk with a wooden panel wall, a circular decorative piece, and a sign indicating 'Marriott Bonvoy'.

14. Fairfield Inn & Suites by Marriott Louisville Airport

Fairfield Inn & Suites by Marriott Louisville Airport
3.0 star property
7.3 km from Cherokee Seneca
8.8 out of 10, Excellent, (815 reviews)
"Super facility’s, can’t say enough good things about it!!"
United States
Clare
The price is NT$2,952
NT$3,473 total
includes taxes & fees
Oct 6 - Oct 7
Fairfield Inn & Suites by Marriott Louisville Airport
An outdoor patio with a stone fire pit, wicker furniture, and a stone wall.

15. Residence Inn by Marriott Louisville East/Oxmoor

Residence Inn by Marriott Louisville East/Oxmoor
3.0 star property
5.9 km from Cherokee Seneca
9.6 out of 10, Exceptional, (325 reviews)
"Nice property and breakfast was good selection"
United States
Brandon
The price is NT$5,225
NT$6,148 total
includes taxes & fees
Oct 4 - Oct 5
Residence Inn by Marriott Louisville East/Oxmoor
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

16. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 4.9 km from Cherokee Seneca
9.2 out of 10, Wonderful, (1,101 reviews)
"Great property close to amazing restaurants"
United States
Tyler
The price is NT$4,843
NT$5,698 total
includes taxes & fees
Oct 26 - Oct 27
Hotel Genevieve part of JdV by Hyatt
Lobby

17. Hilton Garden Inn Louisville Airport

Hilton Garden Inn Louisville Airport
3.0 star property
Fairgrounds, 6.9 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,000 reviews)
"great location, great staff, easy airport shuttle rides. we loved the breakfast buffet too."
United States
Brian
The price is NT$4,074
NT$4,794 total
includes taxes & fees
Oct 17 - Oct 18
Hilton Garden Inn Louisville Airport
An indoor swimming pool with clear blue water, surrounded by large windows offering a view of the outdoors.

18. Hampton Inn & Suites By Hilton Louisville East Oxmoor

Hampton Inn & Suites By Hilton Louisville East Oxmoor
2.5 star property
5.8 km from Cherokee Seneca
9.6 out of 10, Exceptional, (259 reviews)
"Friendly and accommodating staff"
United States
Patty
The price is NT$3,488
NT$4,104 total
includes taxes & fees
Oct 11 - Oct 12
Hampton Inn & Suites By Hilton Louisville East Oxmoor
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.

19. Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville, 6.2 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
"Great stay"
United States
Jacobi
The price is NT$7,371
NT$8,672 total
includes taxes & fees
Oct 17 - Oct 18
Louisville Marriott Downtown
A modern bar area with a circular bar, multiple seating options, and a large screen.

20. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
3.0 star property
Downtown Louisville, 5.8 km from Cherokee Seneca
9.4 out of 10, Exceptional, (1,004 reviews)
"Great property in a great location!"
United States
Erin
The price is NT$3,286
NT$3,866 total
includes taxes & fees
Oct 25 - Oct 26
Cambria Hotel Louisville Downtown-Whiskey Row
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most.
A steamboat docked at a pier with a bridge in the background.

Downtown Louisville

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

A nighttime cityscape with a brightly lit bridge and a skyline featuring a prominent dome-shaped building.

St. Matthews

Major shopping destination with the fifth-largest mall in Kentucky, Mall St. Matthews, and smaller centers along Shelbyville Road. Don't miss the historic St. Matthew's Episcopal Church and Holy Trinity.

A city skyline at dusk with illuminated buildings reflecting on the water.

Jeffersontown

Jeffersontown is known for its abundant dining options, and you can plan a trip to Jeffersontown Commons Shopping Center and Bluegrass Indoor Karting while you're in town.

A nighttime hot air balloon festival with colorful balloons, including one labeled "OLIVER WINERY."
Photo by Hyelsinta
Open Photo by Hyelsinta

Fairgrounds

While visiting Fairgrounds, you might make a stop by sights like Freedom Hall and Kentucky Kingdom.

A historical marker for the Conrad-Caldwell House, detailing its architectural style and history.

Old Louisville

Boasting Victorian architecture and the highest concentration of stained glass windows in residential homes, Old Louisville offers a walkable neighborhood with pedestrian-only streets, diverse dining options, and attractions like Central Park and the Conrad-Caldwell House.

Top Cherokee Seneca Hotel Reviews

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

10/10 Excellent
"This is our second year staying with them for B & B! They are great! My only complaint is they opened the shuttle up to locals that caused a delay to hotel guests. They also blocked Football games on the TV in your room so you had to watch them in the bar. Two things that are making us consider staying somewhere else next year."
Beth 4-night trip
Posted 1 hour ago
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Frequently asked questions

What is Cherokee Seneca like?
You'll be sure to have fun visiting Louisville's Cherokee Seneca neighborhood.
If I need to cancel my hotel reservation in Cherokee Seneca, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to review top deals in Cherokee Seneca.
Where can I learn more about changing or cancelling my trip to Cherokee Seneca?
To find more details about changing or cancelling your trip to Cherokee Seneca, head over to our customer service page.
What is there to do around this Louisville neighborhood?
Peterson-Dumesnil House, Historic Frankfort Avenue, and Colonel Sanders' Grave are just a few of the places to visit in and around Cherokee Seneca. Norton Fine Arts Center and Muhammad Ali Gravesite are also worth a visit when you're out sightseeing in Louisville.

Explore a world of travel with Expedia