A sunset over a calm lake with tall trees reflected in the water.

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Check availability on Charleston Resorts & Hotels with Spas

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Jul 3 - Jul 5
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Jul 10 - Jul 12

Our top choices for Charleston hotels with a spa

Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
The price is NT$3,507
NT$3,956 total
includes taxes & fees
Jul 5 - Jul 6
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Charleston

Pool
Breakfast included

Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great room and wonderful staff"
Jeffrey 1-night trip
Posted 2 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Frequently asked questions

Looking for a spa hotel in Charleston?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the opera and restaurants in Charleston—your day trip starts here. Be sure to pay a visit to the churches during your stay. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Charleston?
Experience all that Charleston has to offer when you visit Mississippi River, Ohio River, and Columbus-Belmont State Park. If you have a bit of extra time while you're in the area, you might want to check out Central Park and Sikeston Depot Museum.
What is a Charleston spa hotel?
Spa hotels in Charleston provide lodging and have an on-site spa offering services like facials and body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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