Find Resorts & Hotels with Spas in Cape Girardeau, MO
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Cape Girardeau Resorts & Hotels with Spas
Tonight
Aug 23 - Aug 24Tomorrow
Aug 24 - Aug 25Next weekend
Aug 28 - Aug 30In two weeks
Sep 4 - Sep 6Our top choices for Cape Girardeau hotels with a spa
1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
- Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
NT$3,250
NT$3,666 total
includes taxes & fees
Sep 21 - Sep 22
Top Cape Girardeau Hotel Reviews
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Everything was amazing. Check-in was easy. The staff was helpful in recommending things to do. It was clean and quiet. We very much enjoyed our stay."
Frequently asked questions
Explore a world of travel with Expedia
- Cheap Hotels in Sikeston
- Hotels near Cape Splash Family Aquatic Center
- Apartments in Mississippi County
- Pet-Friendly Hotels in Dexter
- Cheap Hotels in Charleston
- Adults Only Resorts & in Southeast Missouri
- Pet-Friendly Hotels in Perryville
- Hotels with a Pool in Fredericktown
- Resorts & Hotels with Spas in Perryville
- Winery Hotels in Ste Genevieve
- 5 Star Hotels in Bertrand
- Hotel Wedding Venues Hotels in Perryville
- Historic Hotels in Ste Genevieve
- Fredericktown Hotels
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Charleston Hotels
- Bertrand Hotels
- Bloomfield Hotels
- Perryville Hotels
- Hotels near Cape Girardeau Conservation Nature Center
- Gay friendly Hotels in Miner
- Hotels near Missouri's National Veterans Memorial
- 3 Star Hotels in Oran
- Cape Girardeau Hotels
- Hotels with an Indoor Pool in Jackson
- Hotels with smoking rooms in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Luxury Hotels in Sikeston
- Pet-Friendly Hotels in Charleston
- Marble Hill Hotels
- Pet-Friendly Hotels in Sikeston
- Hotel Wedding Venues Hotels in Southeast Missouri
- Hotels with Bars in Jackson
- Hotels near Sikeston Memorial Municipal
- Apartments in Scott County
- Flights from Indiana (IDI) to Cape Girardeau (CGI)
- Flights from Cheyenne (CYS) to Cape Girardeau (CGI)
- Flights from Gambell (GAM) to Cape Girardeau (CGI)
- Flights from Kingaroy (KGY) to Cape Girardeau (CGI)
- Flights from Ilhéus Airport (IOS) to Cape Girardeau (CGI)
- Flights from Los Angeles (LAX) to Cape Girardeau (CGI)
- Flights from Gulfport (GPT) to Cape Girardeau (CGI)
- Flights from Shanghai (PVG) to Cape Girardeau (CGI)
- Flights from South Bend (SBN) to Sikeston (SIK)
- Flights from Billings (BIL) to Cape Girardeau (CGI)
- Flights from Rhinelander (RHI) to Cape Girardeau (CGI)
- Flights from Fayetteville (XNA) to Cape Girardeau (CGI)
- Flights from Joplin (JLN) to Cape Girardeau (CGI)
- Flights to Charleston
- Flights from Elmira (ELM) to Cape Girardeau (CGI)
- Flights from Fort Smith (FSM) to Cape Girardeau (CGI)
- Flights from Hartford (BDL) to Cape Girardeau (CGI)
- Flights from Lafayette (LFT) to Cape Girardeau (CGI)
- Flights from Fresno (FAT) to Cape Girardeau (CGI)
- Flights from Fredericktown
- Flights from Andrews (ADR) to Cape Girardeau (CGI)
- Flights from Hays (HYS) to Cape Girardeau (CGI)
- Flights from Boise (BOI) to Cape Girardeau (CGI)
- Flights from Harare (HRE) to Cape Girardeau (CGI)
- Flights to Fredericktown
- Flights from Perth (PER) to Cape Girardeau (CGI)
- Flights from Chicago (CHI) to Cape Girardeau (CGI)
- Flights from Montgomery (MGM) to Cape Girardeau (CGI)
- Flights from Marsa Matruh (MUH) to Cape Girardeau (CGI)
- Flights from Mexico City (MEX) to Cape Girardeau (CGI)
- Flights from Tupelo (TUP) to Cape Girardeau (CGI)
- Flights from Corvallis (CVO) to Cape Girardeau (CGI)
- Flights from Indianapolis (IND) to Cape Girardeau (CGI)
- Flights from Corozal (CZH) to Cape Girardeau (CGI)
- Flights from Orlando (SFB) to Cape Girardeau (CGI)
- Flights from Hilton Head Island (HHH) to Cape Girardeau (CGI)
- Flights from Escanaba (ESC) to Cape Girardeau (CGI)
- Flights from Dhaka (DAC) to Cape Girardeau (CGI)
- Flights from Oakland (OAK) to Cape Girardeau (CGI)
- Flights from Stuart (SUA) to Cape Girardeau (CGI)
- Flights from Santa Barbara (SBA) to Cape Girardeau (CGI)
- Flights from Friedheim
- Flights from Lawton (LAW) to Cape Girardeau (CGI)
- Flights from Meridian (MEI) to Cape Girardeau (CGI)
- Dollar Rent A Car Rental Cars in Pocahontas
- Car rental Dexter
- Car rental Jackson
- Enterprise Rental Cars in Benton
- Car rentals near Lazy L Safari Park
- Enterprise Rental Cars in Lambert
- Budget Rental Cars in Oran
- Enterprise Rental Cars in Miner
- Fox Rental Cars Rental Cars in Cape Girardeau Municipal
- Enterprise Rental Cars in Cape Girardeau Municipal