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Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22
In one month
Dec 4 - Dec 6
In two months
Jan 1 - Jan 3

Our top choices for Cairo motels

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

1. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is NT$2,173
NT$2,434 total
includes taxes & fees
Nov 8 - Nov 9
Eagle Inn Charleston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (685 reviews)
"Breakfast was light but good"
United States
zandra
The price is NT$1,932
NT$2,163 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top reviews in Cairo

A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo

10/10 Excellent

Amenities, microwave, refrigerator,iron and iron board,Shower soap options
United States
Maurice
Reviewed February 10, 2026
Quality Inn Cairo I-57

Frequently Asked Questions

What can I expect from a motel trip to Cairo?

If you're having difficulty finding a motel in Cairo, let Expedia help you find motels or similar properties from more than 29 lodging options in the larger area. Simply use our search tools to filter by nightly room rate or cost-saving amenities such as free breakfast and free airport transportation.

What's it like to stay in a motel?

When you stay at a motel, you're likely to find a free parking spot and an outdoor pool. With a stay at a motel, you'll often have access to your room from an outside corridor overlooking the parking lot. The word "motel" was conceived in 1925 in San Luis Obispo, California by the owner of the Milestone Mo-Tel.

What are the best motels in Cairo?

Here you'll find some of our customers’ favorite motels to book in the larger area. Super 8 by Wyndham Charleston/Sikeston East MO is located 10 mi (16.2 km) from the heart of Cairo. Enjoy access to the business center, and freebies including breakfast, WiFi, and parking. Eagle Inn Charleston: Free WiFi and free parking are available during your stay, along with room amenities like a microwave. Central Cairo is 9.3 mi (14.9 km) away.

What can I do in Cairo?

Enjoy nature with a stop at Mississippi River and Ohio River Valley. While you're checking out the area, consider visiting Fort Defiance State Park, Ballard Wildlife Management Area, and Columbus-Belmont State Park.

What's the seasonal weather like in Cairo?

Weather can make or break a roadtrip, so we've gathered some data about year-round temperatures in Cairo to help you plan yours. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

What are my options for getting around Cairo when staying in a motel?

We’ve gathered some information about getting around Cairo to help you navigate your stay: Fly into Cairo, IL (CIR-Cairo Regional), which is located 4.7 mi (7.5 km) away from the city center. Otherwise, you can search for flights to Paducah, KY (PAH-Barkley Regional), which is 22.9 mi (36.8 km) away. If you'd like to explore around the area, you may want to rent a car for your trip.