A calm river with boats, lush greenery, and a clear blue sky.

Big Pine Key 5 Stars Hotels

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Check availability on Big Pine Key 5 Star Hotels

Tonight
Oct 19 - Oct 20
Tomorrow
Oct 20 - Oct 21
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Big Pine Key 5-star hotels

An aerial view of a resort with a central pool, multiple buildings, and a beach area with sun loungers.
An aerial view of a resort with a large building, a beach, and a pier in the background.
A bar area with wooden chairs, a bar counter, and a variety of bottles and glasses.
A beach scene with two white chairs, a hammock, and palm trees.

1. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
Marathon
United States
Clinton
NT$6,765
NT$9,552 total
includes taxes & fees
Oct 21 - Oct 22
Isla Bella Beach Resort & Spa
A modern two-story house with a garage, surrounded by well-maintained landscaping and palm trees.
An aerial view of a resort with a central swimming pool, sun loungers, and palm trees.
A covered pathway leading to a building with white walls and a tiled floor.
A bedroom with a large bed, a ceiling fan, and a view of greenery through the windows.

2. Sea Glass Cove

Sea Glass Cove
Marathon
Sea Glass Cove
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy Marathon FL
NT$6,195
NT$9,044 total
Nov 15 - Nov 16
includes taxes & fees
8.8/10 Excellent! (1,005 reviews)
Tranquility Bay Beachfront Hotel and Resort
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

1996 Overseas Highway Marathon FL
NT$4,756
NT$6,570 total
Nov 10 - Nov 11
includes taxes & fees
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club

58182 Overseas Hwy Marathon FL
NT$6,242
NT$8,578 total
Nov 17 - Nov 18
includes taxes & fees
Grassy Flats Resort & Beach Club
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A coastal town with a beach, clear waters, a pier, and lush greenery.

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Amazing resort. Room was above expectations, everything was so clean, staff so friendly. Great accommodations & dining options. We will be back!"
Anthony 2-night trip
Posted 3 hours ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
You'll find a variety of pricing options for 5-star hotels in Big Pine Key on Expedia. The amount you pay will depend on when you want to travel, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to find the ideal high-end stay.
  • Search for the lowest price per night from NT$6,570
What makes a hotel 5 stars in Big Pine Key?
Flawless guest service characterizes every 5-star hotel in Big Pine Key. From the moment you enter the lobby, staff attend to your every whim, whether recommending activities or providing a turn-down service. Also, hotels have to offer superior conveniences to obtain a 5-star rating. These can include luxury bath products, saunas or spas, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find an upscale retreat in Big Pine Key where most of what you need is included. Next, narrow your results for properties that have 5 stars and are described as "All inclusive." The most important thing on the agenda at these stays? Pure enjoyment and indulgence.

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