Hampton Inn & Suites St. Louis/South I-55 combines comfort with practicality in an ideal location. Guests enjoy a satisfying breakfast buffet each morning, can relax beside the welcoming lobby fireplace, or take advantage of the indoor swimming pool during their stay.
St. Louis is home to Hampton Inn & Suites St. Louis/South I-55. St. Louis Zoo is a popular attraction and the area's natural beauty can be seen at Mississippi River and Forest Park. BounceU of St. Louis and Kennedy Rink are also worth visiting. Visit our St. Louis travel guide
4200 Midamerica Lane, St. Louis, MO, 63129
What's nearby
Busch Stadium
16 min drive - 27.2 km
Gateway Arch
17 min drive - 27.8 km
Enterprise Center
17 min drive - 26.8 km
St. Louis Union Station
18 min drive - 27.2 km
Barnes Jewish South Campus
5 min walk - 0.4 km
Getting around
Kirkwood Station
14 min drive
St. Louis Lambert Intl. Airport (STL)
31 min drive
Restaurants
McDonald's
3 min drive
Burger King
10 min walk
Popeyes Louisiana Kitchen
3 min walk
Hardee's / Red Burrito
10 min walk
Rich & Charlie's Italian Restaurant
3 min drive
About this property
Hampton Inn & Suites St. Louis/South I-55
Hotel near Mississippi River
At Hampton Inn & Suites St. Louis/South I-55, you can look forward to a free breakfast buffet, a grocery/convenience store, and dry cleaning/laundry services. Free in-room WiFi is available to all guests, along with a fireplace in the lobby and a gym.
Additional perks include:
An indoor pool
Free self parking
Express check-in, free newspapers, and a computer station
Laundry services, a vending machine, and 1 meeting room
Guest reviews speak highly of the breakfast and helpful staff
Room features
All 92 rooms offer comforts such as air conditioning, as well as perks like free WiFi and safes. Guest reviews speak positively of the clean rooms at the property.
More conveniences in all rooms include:
Bathrooms with free toiletries and hair dryers
37-inch LCD TVs with cable channels
Wardrobes/closets, refrigerators, and microwaves
Similar properties
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
Available in all rooms: Free WiFi and wired internet
Available in some public areas: Free WiFi and wired internet
Parking and transportation
Free self parking on site
Wheelchair-accessible parking and van parking available
Food and drink
Free buffet breakfast available daily 6:00 AM to 10:00 AM
Coffee and tea in common areas
Things to do
Gym
Indoor pool
TV in common areas
Family friendly
Grocery/convenience store
In-room crib
In-room microwave
In-room refrigerator
Indoor pool
Laundry facilities
Conveniences
24-hour front desk
ATM
Free newspapers in lobby
Grocery/convenience store
Laundry facilities
Luggage storage
Safe at front desk
Vending machine
Guest services
Dry cleaning/laundry service
Housekeeping (daily)
Business services
753 square feet of conference space
Business center
Computer station
Meeting room
Accessibility
If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Elevator
Phone accessibility kit
Stair-free path to entrance
Well-lit path to entrance
Wheelchair accessible (may have limitations)
Wheelchair-accessible business center
Wheelchair-accessible concierge desk
Wheelchair-accessible gym
Wheelchair-accessible parking
Wheelchair-accessible path to elevator
Wheelchair-accessible pool
Wheelchair-accessible public washroom
Wheelchair-accessible registration desk
Wheelchair-accessible van parking
More
1 building
5 floors
Banquet hall
Built in 2010
Fireplace in lobby
Smoking not allowed
Room amenities
Bedroom
Bedsheets provided
Blackout drapes
Free crib
Bathroom
Free toiletries
Hair dryer
Private bathroom
Towels provided
Entertainment
37-inch LCD TV with cable channels
Pay movies
Food and drink
Coffee/tea maker
Microwave
Refrigerator
More
Air conditioning (climate-controlled)
Connecting rooms available
Free local calls
Free weekday newspapers
Iron/ironing board
Phone
Safe
Policies
Check-in
Check-in start time: 3 PM; Check-in end time: midnight
Contactless check-in available
Express check-in available
Check-out
Check-out before 11 AM
Contactless check-out available
Special check-in instructions
Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools
Access methods
Staffed front desk
Pets
Pets allowed for an extra charge of USD 75 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs and cats only
2 total pets
Pets cannot be left unattended
Children and extra beds
Children are welcome
Rollaway/extra beds are not available
Free cribs are available on request at the property
Property payment types
Important information
Optional extras
Pet fee: USD 75 per accommodation, per stay
Service animals are exempt from fees
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
We should mention
Pool access available from 8 AM to 10 PM
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
Children under 13 years old are not allowed in the swimming pool or fitness facility without adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)
Property is also known as
Hampton Inn I-55
Hampton Inn I-55 St.Louis
Hampton Inn South St.Louis
Hampton Inn St.Louis I-55
Hampton Inn St.Louis South
Hampton Inn St.Louis South I-55
Hampton Inn St.Louis South I-55 Hotel
Hampton Inn St.Louis South I-55 Hotel St. Louis
Hampton Inn St.Louis South I-55 St. Louis
St.Louis South
Hampton Inn Suites St.Louis South at I 55
Frequently asked questions
Does Hampton Inn & Suites St. Louis/South I-55 have a pool?
Yes, this property has an indoor pool. Pool access is from 8 AM–10 PM.
How much does it cost to stay at Hampton Inn & Suites St. Louis/South I-55?
As of 2026/3/10, prices found for a 1-night stay for 2 adults at Hampton Inn & Suites St. Louis/South I-55 on 2026/4/5 start from NT$3,497, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
Is Hampton Inn & Suites St. Louis/South I-55 pet-friendly?
Yes, Hampton Inn & Suites St. Louis/South I-55 allows cats and dogs (limit 2 total). There's a fee of USD 75 per accommodation, per stay. Service animals are exempt from fees.
How much is parking?
Self parking is free at this property.
What time is check-in at Hampton Inn & Suites St. Louis/South I-55?
Check-in start time: 3 PM; Check-in end time: midnight.
What time is check-out at Hampton Inn & Suites St. Louis/South I-55?
Check-out is at 11 AM.
Where is Hampton Inn & Suites St. Louis/South I-55 located?
Situated in St. Louis, this hotel is 0.3 mi (0.6 km) from Barnes Jewish South Campus and within 3 mi (5 km) of BounceU of St. Louis and St Anthony's. Kindred Hospital St. Louis South and Kennedy Rink are also within 3 mi (5 km).
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Reviews
Hampton Inn & Suites St. Louis/South I-55 Reviews
9.6
Exceptional
All reviews shown are from real guest experiences. Only travelers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.More informationOpens in a new window
Clean room, good breakfast. Nice, safe area. But the staff was the best I have encountered in a long time. From check in, check out to the breakfast staff. I cannot say enough. We stayed 12/6/25 - one night and I would come back in a heartbeat.
Great experience for a weekend in St Louis, the hotel convenience is great, staff very polite in the breakfast and all match with the content in the site, recommend!
Sandro
Stayed 2 nights in Jun 2025
10/10 Excellent
John
2025/7/15
The best hotel staff I’ve ever encountered.
John
Stayed 2 nights in Jul 2025
10/10 Excellent
Ariona
2025/9/2
Liked: Amenities
Our room was cleaned by Tiff and it was in perfect condition. Pool area was clean as well as the lobby and dining area. You can tell the staff cares. Everyone was very hospitable at breakfast. I also love that you can tip the support staff through the qr code. Would highly reccomend
Needed a hotel for an overnight. This was a great hotel. Very friendly staff and very clean. Good hot breakfast served. Would definitely stay there again if in the area.
I’m a traveling band mom, so I’ve been in three different hotel franchises in the last three weeks. This was the best! When I walked in, I was shocked at how crisp and clean everything was. Great service, they let me check in early, which was extremely helpful. The room was noiiiiiice! And I really need to know where I can buy their shampoo and conditioner, because my hair has never been so manageable. I didn’t have time to swim, but their pool has play stuff and it’s nice and warm in there. I will be back! It’s a great distance from St Louis, you can get there in no time and still be in the burbs
Like any other highway hotel it serves purpose, but we do stay here often. We have family in St. Louis and there are hundreds of choices for hotels. We choose this property brcause of the staff they are always friendly helpful and the hotel is always clean.