The Best Resorts & Hotels with Spas in Southern Indiana from NT$2,743 in 2026

A modern glass building with a curved facade and a sign reading "The Kentucky Center".

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Our top choices for Southern Indiana hotels with a spa

A treatment room with a massage table, a desk with a computer, and a large mirror.

A golf course with a flag, a sand bunker, and a building in the background.

A large, multi-story hotel with a prominent dome and arched windows, featuring a well-lit entrance and landscaped gardens.

A poolside area with lounge chairs and a towel with a monogram.

1. Belterra Casino Resort

Florence

Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.

NT$4,224

NT$5,119 total

includes taxes & fees

Sep 24 - Sep 25

A restaurant with round tables, chairs, chandeliers, and a bar area.

A large hotel with a prominent 'Caesars' sign, multiple floors, and a symmetrical facade.

A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.

A hot tub with a pool, indoor seating area, and a view of the pool.

2. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Elizabeth

Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.

NT$1,904

NT$2,743 total

includes taxes & fees

Oct 11 - Oct 12

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

An outdoor patio with black tables and chairs, surrounded by large windows and a row of arches.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A modern hotel room with a large window, a sofa, a red armchair, and a small table.

3. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville

Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.

NT$5,135

NT$6,041 total

includes taxes & fees

Oct 4 - Oct 5

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A modern bathroom with a shower, a sink, and a large mirror.

4. 21c Museum Hotel Louisville

Downtown Louisville

Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.

NT$5,322

NT$6,419 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A lobby with a marble floor, a reception desk, and a large chandelier.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

5. Omni Louisville Hotel

Downtown Louisville

Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.

NT$4,701

NT$5,531 total

includes taxes & fees

Sep 11 - Sep 12

A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.

A porch with white rocking chairs and a table, a window with blinds, and a view of a green landscape.

A cozy room with a wooden wall, a sofa, and a dining table.

A living room with a sofa, coffee table, and a television mounted on the wall.

6. Pillow and Paddock B&B

La Grange

Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.

NT$9,570

NT$10,550 total

includes taxes & fees

Sep 15 - Sep 16

A hotel lobby with a chandelier, wooden railings, a reception desk, and a large arched doorway.

A conference room with multiple tables and chairs, a flat-screen TV mounted on the wall, and a large window with blinds.

A spacious indoor area with a staircase, a vending machine, and a business center sign.

A hotel room with a bed, desk, chair, and a green accent wall.

7. Quality Inn Seymour I-65

Seymour

Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.

NT$2,674

NT$2,995 total

includes taxes & fees

Oct 9 - Oct 10

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Choose what matters most at spa hotels in Southern Indiana

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Southern Indiana Hotel Reviews

Drury Inn & Suites Evansville East

8/10 Good

"Always a reliable stay. Happy hour at check in is a total value and can absolutely replace going out for dinner if possible."

Big Splash Adventure Indoor Water Park & Resort

10/10 Excellent

"Todo muy bello, pasamos el cumpleaños de nuestro bebé muy bien lugar muy acogedor"

Hampton Inn New Albany Louisville West

10/10 Excellent

"Great location, nice area"

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Book Resorts & Hotels with Spas in Southern Indiana on Expedia.com

Find Resorts & Hotels with Spas in Southern Indiana

Change your mind

Treat yourself

Be picky

Check availability on Southern Indiana Resorts & Hotels with Spas

Our top choices for Southern Indiana hotels with a spa

1. Belterra Casino Resort

2. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

3. Galt House Hotel Trademark Collection by Wyndham

4. 21c Museum Hotel Louisville

5. Omni Louisville Hotel

6. Pillow and Paddock B&B

7. Quality Inn Seymour I-65

Choose what matters most at spa hotels in Southern Indiana

Top Southern Indiana Hotel Reviews

Drury Inn & Suites Evansville East

Big Splash Adventure Indoor Water Park & Resort

Hampton Inn New Albany Louisville West

Explore a world of travel with Expedia