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Dec 23 - Dec 24
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Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Santa Cruz hotels

Standard Room, 1 King Bed | Terrace/patio
Hotel Casa Miranda

Hotel Casa Miranda

Hotel Casa Miranda
2.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (4)
"La atencion es excelente, no asi las instalaciones. El salir de la habitacion para el baño y que este tapado no es muy buena experiencia. Le falta identificacion en la parte de afuera, son aspectos a mejorar "
Mexico
FERNANDO
The price is NT$1,342
NT$1,604 total
includes taxes & fees
Dec 25 - Dec 26
Hotel Casa Miranda
Interior
Mesón de San Andrés

Mesón de San Andrés

Mesón de San Andrés
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (115)
"Love it! "
United States
EFREN
The price is NT$1,718
NT$2,053 total
includes taxes & fees
Dec 26 - Dec 27
Mesón de San Andrés
Lobby
Dos Patios Querétaro Curamoria Collection

Dos Patios Querétaro Curamoria Collection

Dos Patios Querétaro Curamoria Collection
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (128)
"Spacious and clean room. Great service from Valet employees. "
United States
Alfredo
The price is NT$3,235
NT$3,866 total
includes taxes & fees
Dec 25 - Dec 26
Dos Patios Querétaro Curamoria Collection
Premium bedding, blackout drapes, soundproofing, iron/ironing board
Casa Realm

Casa Realm

Casa Realm
3.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (28)
"Great location 👌 "
United States
Crispin
The price is NT$1,468
NT$1,754 total
includes taxes & fees
Dec 30 - Dec 31
Casa Realm
Terrace/patio
Cinco de Mayo Hotel

Cinco de Mayo Hotel

Cinco de Mayo Hotel
2.5 star property
Santa Cruz
7.6 out of 10, Good, (309)
"Kind of an unbeatable location in the historic center of Queretaro. Simple, clean, decent value. "
United States
Shaun
The price is NT$826
NT$987 total
includes taxes & fees
Dec 25 - Dec 26
Cinco de Mayo Hotel
Hallway
Casa Brunella Hotel Boutique

Casa Brunella Hotel Boutique

Casa Brunella Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (233)
"Unique boutique hotel with eccentric decor and spacious room. Centrally located "
United States
Elsa
The price is NT$2,532
NT$3,026 total
includes taxes & fees
Dec 28 - Dec 29
Casa Brunella Hotel Boutique
Exterior
Hotel Úrsula Concept

Hotel Úrsula Concept

Hotel Úrsula Concept
3.0 star property
Santa Cruz
8.6 out of 10, Excellent, (14)
"It is very clean, the bed was great and all in an historic home that has been converted to a charming family run boutique quality hotel. It is very close to an historic church with its huge plaza filled with families and activities and comfortable benches."
United States
Steven
The price is NT$2,643
NT$3,158 total
includes taxes & fees
Jan 6 - 2026/1/7
Hotel Úrsula Concept
Egyptian cotton sheets, premium bedding, down comforters, minibar
Hotel Suites Sofia

Hotel Suites Sofia

Hotel Suites Sofia
3.0 star property
Santa Cruz
8.4 out of 10, Very Good, (46)
"Perfect place for our needs"
United States
Joseph
The price is NT$2,573
NT$3,075 total
includes taxes & fees
Dec 26 - Dec 27
Hotel Suites Sofia
Hallway
Hotel Boutique Casa Altamira

Hotel Boutique Casa Altamira

Hotel Boutique Casa Altamira
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (358)
"Very nice boutique hotel in one of the city center’s main dinning zones. The rooms are new and clean, the parking is good and the neighborhood is pretty"
United States
Ulises
Hotel Boutique Casa Altamira
Interior detail
Hotel Meson de Isabel

Hotel Meson de Isabel

Hotel Meson de Isabel
3.0 star property
Santa Cruz
7.4 out of 10, Good, (59)
"Good place but for the price definitely not worth it"
United States
Manuel
Hotel Meson de Isabel
Sundeck
Hotel & Spa La Mansión del Burro Azul

Hotel & Spa La Mansión del Burro Azul

Hotel & Spa La Mansión del Burro Azul
3.5 star property
Santa Cruz
8.4 out of 10, Very Good, (442)
"The place is absolutely beautiful and original. "
United States
Martha
The price is NT$1,516
NT$1,811 total
includes taxes & fees
Jan 1 - 2026/1/2
Hotel & Spa La Mansión del Burro Azul
Luxury Room, 1 King Bed | Premium bedding, down comforters, in-room safe, individually decorated
Hotel Casa Once

Hotel Casa Once

Hotel Casa Once
3.5 star property
Centro Histórico, 0.5 km from Santa Cruz
9.6 out of 10, Exceptional, (287)
"Amazing hotel "
United States
lizette
The price is NT$2,760
NT$3,298 total
includes taxes & fees
Dec 29 - Dec 30
Hotel Casa Once
Hallway
Hotel Patio Santiago

Hotel Patio Santiago

Hotel Patio Santiago
4.5 star property
Centro Histórico, 0.6 km from Santa Cruz
9.4 out of 10, Exceptional, (405)
"Staff was pleasant, rooms were clean and modern, and it was in a walkable area. It’s a beautiful and relatively new hotel, and a very relaxed stay,"
United States
Alondra
The price is NT$4,105
NT$4,906 total
includes taxes & fees
Jan 18 - 2026/1/19
Hotel Patio Santiago
Courtyard
La Casa del Atrio

La Casa del Atrio

La Casa del Atrio
3.5 star property
Centro Histórico, 1.1 km from Santa Cruz
9.6 out of 10, Exceptional, (474)
"Charming hotel in a historic old building right in the center of town. The staff was super helpful and courteous. We loved our stay."
United States
Prabuddha
The price is NT$2,653
NT$3,170 total
includes taxes & fees
Dec 25 - Dec 26
La Casa del Atrio
Comfort Room | Free WiFi
4Play Motel

4Play Motel

4Play Motel
3.0 star property
13.6 km from Santa Cruz
8.6 out of 10, Excellent, (10)
"Perfect room for couples super clean and comfortable "
United States
Josue Rocky
The price is NT$1,395
NT$1,667 total
includes taxes & fees
Dec 25 - Dec 26
4Play Motel
Front of property
Hotel Estancias VIVE MX el marques Queretaro, Trademark

Hotel Estancias VIVE MX el marques Queretaro, Trademark

Hotel Estancias VIVE MX el marques Queretaro, Trademark
3.0 star property
4.2 km from Santa Cruz
9.6 out of 10, Exceptional, (68)
"We stayed here to catch an early flight from QRO International Airport, and it was a great choice. The staff was very friendly, the facilities were clean and well-kept, and getting an Uber to the airport was quick and easy. The only thing to note is that the elevators are on the smaller side, but I was still able to fit two large suitcases without a problem."
United States
Mishel
The price is NT$1,404
NT$1,677 total
includes taxes & fees
Dec 25 - Dec 26
Hotel Estancias VIVE MX el marques Queretaro, Trademark
Family Double Room | Garden view
Quinta Allende

Quinta Allende

Quinta Allende
3.5 star property
Centro Histórico, 1.1 km from Santa Cruz
9.2 out of 10, Wonderful, (366)
"Very nice, quiet hotel with doves cooing in the morning."
United States
Eric John
Quinta Allende
Garden
The Latit Hotel Querétaro

The Latit Hotel Querétaro

The Latit Hotel Querétaro
3.5 star property
15.5 km from Santa Cruz
8.2 out of 10, Very Good, (579)
"Very good service."
United States
J Santos
The Latit Hotel Querétaro
Property entrance
Hotel Mamá Carlota

Hotel Mamá Carlota

Hotel Mamá Carlota
3.5 star property
Centro Histórico, 0.9 km from Santa Cruz
8.8 out of 10, Excellent, (355)
"Everything was good! The only thing there’s no breakfast. "
United States
MARIANA
The price is NT$1,679
NT$2,006 total
includes taxes & fees
Jan 1 - 2026/1/2
Hotel Mamá Carlota
Restaurant
La Casa de la Marquesa

La Casa de la Marquesa

La Casa de la Marquesa
4.0 star property
Centro Histórico, 1 km from Santa Cruz
8.8 out of 10, Excellent, (559)
"Unbelievable place to stay Love it "
United States
maribel
The price is NT$3,576
NT$4,273 total
includes taxes & fees
Dec 29 - Dec 30
La Casa de la Marquesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.
Mexico which includes mountains and heritage elements

Downtown Querétaro

Downtown Querétaro is known for its abundant dining options, and you can plan a trip to Zenea Garden and Plaza de Armas while you're in town.

Queretaro which includes a city

Centro Histórico

Unique features of Centro Histórico include the historic sites and museums. Make a stop by Zenea Garden or Plaza de Armas while you're exploring the area.

Juriquilla

Juriquilla is noteworthy for its restaurants, and you can make a stop at top attractions like Plaza Juriquilla and Plaza Ubika.

Jurica

Jurica is noteworthy for its shopping, and you can make a stop at top attractions like Antea Lifestyle Center and Urban Center Shopping Mall.

Church of Santa Maria

Downtown Tequisquiapan

You'll enjoy the monuments and shopping in Downtown Tequisquiapan. You might want to make time for a stop at Tequisquiapan Handicraft Market or La Pila Park.

Top Santa Cruz Hotel Reviews

Casa Inn Premium Hotel Queretaro

Casa Inn Premium Hotel Queretaro

10/10 Excellent
"Y"
Jose Raul 1-night trip
Posted 7 days ago
Casa Inn Premium Hotel Queretaro

Frequently asked questions

What is Santa Cruz like?
Travelers to Querétaro's Santa Cruz neighborhood will be sure to enjoy a stay in this neighborhood. Are you looking for Santa Cruz travel tips? Be sure to check out Aqueduct of Santiago de Querétaro and Templo y Convento de la Santa Cruz while you're in the neighborhood.
Where is the best place to stay in Santa Cruz?
Based on Expedia customer reviews, HOTEL & SPA DOÑA URRACA QUERETARO is the highest ranked property in Santa Cruz. This hotel is a short 12-minute walk from Aqueduct of Santiago de Querétaro, and it offers free breakfast and a restaurant. Other top choices in the neighborhood include Hotel Boutique Casa Altamira and Casa Brunella Hotel Boutique.
How many hotels are there in the Santa Cruz area?
Expedia has 45 hotels and other accommodations in Santa Cruz to choose from, making this an ideal home base for exploring the greater Querétaro area.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the top deals on offer in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
For more information about picking new dates or cancelling your trip to Santa Cruz, click here.
What is there to do around this Querétaro neighborhood?
Explore Santa Cruz's landmarks like Aqueduct of Santiago de Querétaro, Templo y Convento de la Santa Cruz, and Arches Viewpoint and learn about the local history. You could also plan a visit to Convent and Temple of Santa Cruz or Querétaro Contemporary Art Museum while you're in the neighborhood. Plaza de Los Fundadores, Casa de la Zacatecana Museum, and Ignacio Mena Rosales House of Culture are just a few of the places to visit in and around Santa Cruz. Plaza de Armas and Querétaro Regional Museum are also worth a visit when you're out sightseeing in Querétaro.