A densely populated cityscape with a prominent historical building with a dome and bell tower in the foreground.

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Oct 2 - Oct 4
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Oct 9 - Oct 11

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Our top choices for Santa Cruz hotels

A spacious lobby with a high ceiling, large columns, and a central fountain. There are several seating areas with modern and classic furniture.

1. Dos Patios Querétaro Curamoria Collection

Dos Patios Querétaro Curamoria Collection
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (157 reviews)
"Lovely place to stay. Highly recommend."
United States
Jenifer
The price is NT$3,908
NT$4,671 total
includes taxes & fees
Sep 29 - Sep 30
Dos Patios Querétaro Curamoria Collection
A hotel corridor with a wooden reception desk, a sign reading "ENTRADA," and a large decorative wall piece.

2. Casa Brunella Hotel Boutique

Casa Brunella Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (269 reviews)
"Great experience, great location and breakfast was good."
United States
Diana
The price is NT$2,592
NT$3,098 total
includes taxes & fees
Sep 29 - Sep 30
Casa Brunella Hotel Boutique
A dining area with wooden tables and chairs, a chandelier, and a fireplace.

3. Cinco de Mayo Hotel

Cinco de Mayo Hotel
2.5 star property
Santa Cruz
7.6 out of 10, Good, (348 reviews)
"Super clean and great location...😊"
United States
Roger
The price is NT$813
NT$972 total
includes taxes & fees
Sep 29 - Sep 30
Cinco de Mayo Hotel

4. HOTEL & SPA DOÑA URRACA QUERETARO

HOTEL & SPA DOÑA URRACA QUERETARO
4.0 star property
Santa Cruz
8.8 out of 10, Excellent, (77 reviews)
"Great location and beautiful property. Breakfast was great!"
United States
Claudia
The price is NT$4,816
NT$5,756 total
includes taxes & fees
Oct 10 - Oct 11
HOTEL & SPA DOÑA URRACA QUERETARO
A hotel room with a bed, bedside lamp, phone, and a small table with a lamp. There is a brick wall on one side and a tiled wall on the other.

5. Hotel Suites Sofia

Hotel Suites Sofia
3.0 star property
Santa Cruz
8.4 out of 10, Very good, (53 reviews)
"Perfect place for our needs"
United States
Joseph
The price is NT$1,437
NT$1,717 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Suites Sofia
A courtyard with round wooden tables and chairs, surrounded by potted plants and a tiled floor.

6. Hotel Meson de Isabel

Hotel Meson de Isabel
3.0 star property
Santa Cruz
7.6 out of 10, Good, (88 reviews)
"They don’t have someone at the front desk all the time. You have to walk up to a hotel across the street to get help checking in. Internet was deficient. The rooms were clean, it was quiet and peaceful. I would stay there again."
United States
Guadalupe
The price is NT$696
NT$831 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Meson de Isabel

7. Casa Realm

Casa Realm
3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (43 reviews)
"Nice place to stay "
United States
Oscar
The price is NT$1,296
NT$1,549 total
includes taxes & fees
Sep 29 - Sep 30
Casa Realm
An entrance with a stone floor, a large chandelier, and a view of the courtyard with potted plants and outdoor seating.

8. Hotel Úrsula Concept

Hotel Úrsula Concept
2.5 star property
Santa Cruz
8.8 out of 10, Excellent, (15 reviews)
"It is very clean, the bed was great and all in an historic home that has been converted to a charming family run boutique quality hotel. It is very close to an historic church with its huge plaza filled with families and activities and comfortable benches."
United States
Steven
The price is NT$1,353
NT$1,616 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Úrsula Concept
A rooftop terrace with lounge chairs, potted plants, and a view of the cityscape.

9. Mesón de San Andrés

Mesón de San Andrés
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (118 reviews)
"This was the perfect hotel for our trip! The staff was very friendly and helpful. Omar answered all of our questions very patiently and gave us great suggestions for things to do and places to visit. It was close enough to walk to the historical center and other attractions. We loved watching the sunset from the rooftop patio and felt like this was our home away from home as we explored the region around Queretaro."
United States
Rachel
The price is NT$1,758
NT$2,101 total
includes taxes & fees
Sep 29 - Sep 30
Mesón de San Andrés
A table with a bottle and two glasses, set against a sunset backdrop.

10. Hotel & Spa La Mansión del Burro Azul

Hotel & Spa La Mansión del Burro Azul
3.5 star property
Santa Cruz
8.4 out of 10, Very good, (455 reviews)
"Excellent"
United States
Rogelio
The price is NT$1,896
NT$2,266 total
includes taxes & fees
Oct 13 - Oct 14
Hotel & Spa La Mansión del Burro Azul
A narrow corridor with potted plants on both sides, a tiled walkway, and a window on the right.

11. Damián Carmona by Homirent

Damián Carmona by Homirent
3.0 star property
Santa Cruz
9.8 out of 10, Exceptional, (6 reviews)
"Building and room was nice and clean. Overall a great stay. My only complaint was the repeated automatic messages I kept receiving and i had to request the check-in code and instructions even though their listing states they provide that info 24 hrs before check-in."
United States
Adan
The price is NT$1,142
NT$1,365 total
includes taxes & fees
Sep 29 - Sep 30
Damián Carmona by Homirent
A compact kitchen with a refrigerator, stove, and microwave.

12. Casona 109 By Homirent

Casona 109 By Homirent
3.0 star property
Santa Cruz
8.0 out of 10, Very good, (1 review)
"Habitación a 15 minutos caminando del centro de Querétaro, la habitación es tal cual las fotografías pero en cuanto a limpieza todavía deja qué desear (piso sucio, me encontré cabellos entre las almohadas, cabecera con polvo...). La habitación es DEMASIADO PEQUEÑA y no sabemos por qué se CALENTABA HORRIBLE! El ventilador ayudaba pero es muy ruidoso y si quieres aire acondicionado debes pagar $150 pesos adicionales por día... No estoy segura si volviera a quedarme en un lugar así... Si tienes...
Mexico
Karla
The price is NT$1,142
NT$1,365 total
includes taxes & fees
Sep 29 - Sep 30
Casona 109 By Homirent
A corridor with a glass ceiling, potted plants, and a sign indicating an evacuation route.

13. Hotel Patio Santiago

Hotel Patio Santiago
4.5 star property
Centro Histórico, 0.6 km from Santa Cruz
9.4 out of 10, Exceptional, (605 reviews)
"Great location in the heart of all the action. A short one block walk to a square with live music, restaurants and shops. The hotel is clean and the staff is top notch. Would stay here again!"
United States
JOBY Lee
The price is NT$4,655
NT$5,563 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Patio Santiago
A modern hotel with multiple floors, a prominent signage, and a well-lit entrance area.

14. Fiesta Inn Express Queretaro Constituyentes

Fiesta Inn Express Queretaro Constituyentes
3.0 star property
Mercurio, 1.1 km from Santa Cruz
9.2 out of 10, Wonderful, (1,003 reviews)
"Breakfast can be better"
United States
Yris
The price is NT$3,326
NT$3,975 total
includes taxes & fees
Oct 16 - Oct 17
Fiesta Inn Express Queretaro Constituyentes
A restaurant with wooden tables and chairs, a bar area with shelves of bottles, and hanging greenery.

15. Domun Hotel

Domun Hotel
3.5 star property
Downtown Querétaro, 2.2 km from Santa Cruz
9.6 out of 10, Exceptional, (1,004 reviews)
"The best hotel in Querétaro!"
Mexico
Jesus
The price is NT$3,098
NT$3,702 total
includes taxes & fees
Oct 13 - Oct 14
Domun Hotel
A staircase leading to a white building with a stone wall and greenery.

16. Hotel Casa Valeria Queretaro Centro

Hotel Casa Valeria Queretaro Centro
2.0 star property
Centro Histórico, 0.7 km from Santa Cruz
9.2 out of 10, Wonderful, (19 reviews)
"Todo excelente 👌"
Mexico
alejandro hurtado
The price is NT$774
NT$925 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Casa Valeria Queretaro Centro
A hotel reception area with a counter, several hanging light fixtures, and a staircase.

17. Hotel Mirabel

Hotel Mirabel
3.0 star property
Zona dos Extendida, 1.1 km from Santa Cruz
9.2 out of 10, Wonderful, (1,349 reviews)
"Clean room, location, breakfast, good service"
United States
Francisco
The price is NT$1,691
NT$2,021 total
includes taxes & fees
Oct 15 - Oct 16
Hotel Mirabel
A modern building with a glass facade, outdoor seating area, and a pool.

18. Hotel Criol

Hotel Criol
3.5 star property
Centro Histórico, 0.5 km from Santa Cruz
9.2 out of 10, Wonderful, (1,002 reviews)
"Excellent place, service and very kind"
Mexico
KI JUNG
The price is NT$2,804
NT$3,449 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Criol
A modern lounge area with multiple seating options, a bar in the background, and large windows allowing natural light.

19. Grand Fiesta Americana Queretaro

Grand Fiesta Americana Queretaro
5.0 star property
2.4 km from Santa Cruz
9.4 out of 10, Exceptional, (1,004 reviews)
"Loved this hotel"
United States
Carlos
The price is NT$5,113
NT$6,109 total
includes taxes & fees
Oct 18 - Oct 19
Grand Fiesta Americana Queretaro
A rooftop terrace with a glass-enclosed infinity pool, a hot tub, and outdoor seating.

20. Hotel Real Alameda

Hotel Real Alameda
3.0 star property
Downtown Querétaro, 1 km from Santa Cruz
9.0 out of 10, Wonderful, (1,009 reviews)
"Excelente Hotel!"
Mexico
José
The price is NT$2,004
NT$2,395 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Real Alameda
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Cruz

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A narrow corridor with potted plants on both sides, a tiled walkway, and a window on the right.
Damián Carmona by Homirent
3.0 star property
9.8
Exceptional
6 reviews
View
A hotel corridor with a wooden reception desk, a sign reading "ENTRADA," and a large decorative wall piece.
Casa Brunella Hotel Boutique
3.5 star property
9.2
Wonderful
269 reviews
View
Casa Realm
3.0 star property
9.0
Wonderful
43 reviews
View
A rooftop terrace with lounge chairs, potted plants, and a view of the cityscape.
Mesón de San Andrés
3.0 star property
9.2
Wonderful
118 reviews
View
HOTEL & SPA DOÑA URRACA QUERETARO
4.0 star property
8.8
Excellent
77 reviews
View

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.
A stone viaduct with multiple arches, surrounded by trees and a clear sky.

Downtown Querétaro

Downtown Querétaro is known for its abundant dining options, and you can plan a trip to Zenea Garden and Plaza de Armas while you're in town.

Teatro de la Republica with its reflection in the water, surrounded by city buildings.

Juriquilla

Juriquilla is noteworthy for its restaurants, and you can make a stop at top attractions like Plaza Juriquilla and Bicentennial Park.

A nighttime view of a bridge with illuminated columns and light trails from passing vehicles.

Centro Histórico

Unique features of Centro Histórico include the historic sites and museums. Make a stop by Zenea Garden or Plaza de Armas while you're exploring the area.

A cityscape with a prominent bridge and a distant hill with buildings.

Jurica

Jurica is noteworthy for its shopping, and you can make a stop at top attractions like Antea Lifestyle Center and Urban Center Shopping Mall.

A church with a large stained glass window and bell towers.

Downtown Tequisquiapan

You'll enjoy the monuments and shopping in Downtown Tequisquiapan. You might want to make time for a stop at Tequisquiapan Handicraft Market or Ezequiel Montes Street Market.

Top Santa Cruz Hotel Reviews

Stadía Suites Querétaro Centro Histórico

Stadía Suites Querétaro Centro Histórico

10/10 Excellent
"My stay at this property was excellent. The staff were friendly and welcoming. The hotel smelled great all over and my room was large with good a/c and comfortable bed."
Patrick 3-night trip
Posted 15 hours ago
Stadía Suites Querétaro Centro Histórico

Frequently asked questions

What is Santa Cruz like?
Travelers to Querétaro's Santa Cruz neighborhood will be sure to enjoy a stay in this neighborhood. Are you looking for Santa Cruz travel tips? Be sure to check out Aqueduct of Santiago de Querétaro and Templo y Convento de la Santa Cruz while you're in the neighborhood.
Where is the best place to stay in Santa Cruz?
Based on our traveler data, Dos Patios Querétaro Curamoria Collection is one of the top choices for your stay in Santa Cruz. This hotel offers a full-service spa and free breakfast. Other good choices for your stay in the neighborhood include Hotel Meson de Isabel and Cinco de Mayo Hotel.
How many hotels are there in the Santa Cruz area?
Expedia has 49 hotels and other accommodations in Santa Cruz to choose from, making this an ideal home base for exploring the greater Querétaro area.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the top deals on offer in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
For more information about picking new dates or cancelling your trip to Santa Cruz, click here.
What is there to do around this Querétaro neighborhood?
Explore Santa Cruz's landmarks like Aqueduct of Santiago de Querétaro, Templo y Convento de la Santa Cruz, and Arches Viewpoint and learn about the local history. You could also plan a visit to Convent and Temple of Santa Cruz or Querétaro Contemporary Art Museum while you're in the neighborhood. Plaza de Los Fundadores, Casa de la Zacatecana Museum, and Ignacio Mena Rosales House of Culture are just a few of the places to visit in and around Santa Cruz. Plaza de Armas and Querétaro Regional Museum are also worth a visit when you're out sightseeing in Querétaro.