Find hotels in Santa Cruz, Querétaro

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Our top choices for Santa Cruz hotels

Dos Patios Querétaro Curamoria Collection

Dos Patios Querétaro Curamoria Collection
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (128)
"Spacious and clean room. Great service from Valet employees. "
United States
Alfredo
The price is NT$3,225
NT$3,854 total
includes taxes & fees
Dec 27 - Dec 28
Dos Patios Querétaro Curamoria Collection

Hotel Boutique Casa Altamira

Hotel Boutique Casa Altamira
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (358)
"Very nice boutique hotel in one of the city center’s main dinning zones. The rooms are new and clean, the parking is good and the neighborhood is pretty"
United States
Ulises
Hotel Boutique Casa Altamira

Casa Brunella Hotel Boutique

Casa Brunella Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (233)
"Unique boutique hotel with eccentric decor and spacious room. Centrally located "
United States
Elsa
The price is NT$2,540
NT$3,035 total
includes taxes & fees
Dec 28 - Dec 29
Casa Brunella Hotel Boutique

Mesón de San Andrés

Mesón de San Andrés
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (115)
"Love it! "
United States
EFREN
The price is NT$1,717
NT$2,052 total
includes taxes & fees
Dec 27 - Dec 28
Mesón de San Andrés

Hotel Suites Sofia

Hotel Suites Sofia
3.0 star property
Santa Cruz
8.4 out of 10, Very Good, (46)
"Perfect place for our needs"
United States
Joseph
The price is NT$2,192
NT$2,620 total
includes taxes & fees
Dec 29 - Dec 30
Hotel Suites Sofia

Hotel Casa Miranda

Hotel Casa Miranda
2.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (4)
"La atencion es excelente, no asi las instalaciones. El salir de la habitacion para el baño y que este tapado no es muy buena experiencia. Le falta identificacion en la parte de afuera, son aspectos a mejorar "
Mexico
FERNANDO
The price is NT$1,342
NT$1,603 total
includes taxes & fees
Jan 5 - 2026/1/6
Hotel Casa Miranda

Casa Realm

Casa Realm
3.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (28)
"Great location 👌 "
United States
Crispin
The price is NT$1,472
NT$1,760 total
includes taxes & fees
Jan 6 - 2026/1/7
Casa Realm

Hotel Úrsula Concept

Hotel Úrsula Concept
3.0 star property
Santa Cruz
8.6 out of 10, Excellent, (14)
"It is very clean, the bed was great and all in an historic home that has been converted to a charming family run boutique quality hotel. It is very close to an historic church with its huge plaza filled with families and activities and comfortable benches."
United States
Steven
The price is NT$2,642
NT$3,157 total
includes taxes & fees
Jan 1 - 2026/1/2
Hotel Úrsula Concept

Hotel & Spa La Mansión del Burro Azul

Hotel & Spa La Mansión del Burro Azul
3.5 star property
Santa Cruz
8.4 out of 10, Very Good, (442)
"The place is absolutely beautiful and original. "
United States
Martha
The price is NT$1,520
NT$1,817 total
includes taxes & fees
Jan 1 - 2026/1/2
Hotel & Spa La Mansión del Burro Azul

Hotel Meson de Isabel

Hotel Meson de Isabel
3.0 star property
Santa Cruz
7.4 out of 10, Good, (60)
"Good place but for the price definitely not worth it"
United States
Manuel
Hotel Meson de Isabel

Cinco de Mayo Hotel

Cinco de Mayo Hotel
2.5 star property
Santa Cruz
7.6 out of 10, Good, (310)
"Kind of an unbeatable location in the historic center of Queretaro. Simple, clean, decent value. "
United States
Shaun
The price is NT$826
NT$987 total
includes taxes & fees
Dec 30 - Dec 31
Cinco de Mayo Hotel

Hotel Casa Once

Hotel Casa Once
3.5 star property
Centro Histórico, 0.5 km from Santa Cruz
9.6 out of 10, Exceptional, (288)
"Amazing hotel "
United States
lizette
The price is NT$2,759
NT$3,298 total
includes taxes & fees
Dec 29 - Dec 30
Hotel Casa Once

Hotel Patio Santiago

Hotel Patio Santiago
4.5 star property
Centro Histórico, 0.6 km from Santa Cruz
9.4 out of 10, Exceptional, (405)
"Staff was pleasant, rooms were clean and modern, and it was in a walkable area. It’s a beautiful and relatively new hotel, and a very relaxed stay,"
United States
Alondra
The price is NT$4,104
NT$4,905 total
includes taxes & fees
Jan 18 - 2026/1/19
Hotel Patio Santiago

La Casa de la Marquesa

La Casa de la Marquesa
4.0 star property
Centro Histórico, 1 km from Santa Cruz
8.8 out of 10, Excellent, (559)
"Unbelievable place to stay Love it "
United States
maribel
The price is NT$3,586
NT$4,286 total
includes taxes & fees
Dec 29 - Dec 30
La Casa de la Marquesa

La Casa del Atrio

La Casa del Atrio
3.5 star property
Centro Histórico, 1.1 km from Santa Cruz
9.6 out of 10, Exceptional, (474)
"Charming hotel in a historic old building right in the center of town. The staff was super helpful and courteous. We loved our stay."
United States
Prabuddha
The price is NT$2,360
NT$2,821 total
includes taxes & fees
Dec 27 - Dec 28
La Casa del Atrio

Hotel Hércules

Hotel Hércules
4.0 star property
Hércules, 2.8 km from Santa Cruz
9.4 out of 10, Exceptional, (184)
"Beautiful hotel! "
France
Julio Cesar
Hotel Hércules

Mesón de Santa Rosa Luxury Hotel

Mesón de Santa Rosa Luxury Hotel
4.0 star property
Centro Histórico, 0.6 km from Santa Cruz
8.4 out of 10, Very Good, (622)
"Excelente hotel"
Mexico
Mireya
Mesón de Santa Rosa Luxury Hotel

Gran Hotel de Querétaro

Gran Hotel de Querétaro
3.5 star property
Centro Histórico, 0.9 km from Santa Cruz
9.0 out of 10, Wonderful, (1004)
"Great location and easy access to everything in the downtown area"
United States
Hector
The price is NT$3,075
NT$3,674 total
includes taxes & fees
Dec 30 - Dec 31
Gran Hotel de Querétaro

Grand Fiesta Americana Queretaro

Grand Fiesta Americana Queretaro
5.0 star property
2.4 km from Santa Cruz
9.4 out of 10, Exceptional, (1004)
"Excelente "
Mexico
Jorge
The price is NT$4,999
NT$5,974 total
includes taxes & fees
Dec 28 - Dec 29
Grand Fiesta Americana Queretaro

Casa Santiago Hotel Boutique

Casa Santiago Hotel Boutique
3.5 star property
Centro Histórico, 0.7 km from Santa Cruz
9.4 out of 10, Exceptional, (197)
"Excelente "
United States
Hector
Casa Santiago Hotel Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.

Downtown Querétaro

Downtown Querétaro is known for its abundant dining options, and you can plan a trip to Zenea Garden and Plaza de Armas while you're in town.

Centro Histórico

Unique features of Centro Histórico include the historic sites and museums. Make a stop by Zenea Garden or Plaza de Armas while you're exploring the area.

Juriquilla

Juriquilla is noteworthy for its restaurants, and you can make a stop at top attractions like Plaza Juriquilla and Plaza Ubika.

Jurica

Jurica is noteworthy for its shopping, and you can make a stop at top attractions like Antea Lifestyle Center and Urban Center Shopping Mall.

Downtown Tequisquiapan

You'll enjoy the monuments and shopping in Downtown Tequisquiapan. You might want to make time for a stop at Tequisquiapan Handicraft Market or La Pila Park.

Top Santa Cruz Hotel Reviews

Frequently asked questions

What is Santa Cruz like?
Travelers to Querétaro's Santa Cruz neighborhood will be sure to enjoy a stay in this neighborhood. Are you looking for Santa Cruz travel tips? Be sure to check out Aqueduct of Santiago de Querétaro and Templo y Convento de la Santa Cruz while you're in the neighborhood.
Where is the best place to stay in Santa Cruz?
Based on Expedia customer reviews, HOTEL & SPA DOÑA URRACA QUERETARO is the highest ranked property in Santa Cruz. This hotel is a short 12-minute walk from Aqueduct of Santiago de Querétaro, and it offers free breakfast and a restaurant. Other top choices in the neighborhood include Hotel Boutique Casa Altamira and Casa Brunella Hotel Boutique.
How many hotels are there in the Santa Cruz area?
Expedia has 45 hotels and other accommodations in Santa Cruz to choose from, making this an ideal home base for exploring the greater Querétaro area.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the top deals on offer in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
For more information about picking new dates or cancelling your trip to Santa Cruz, click here.
What is there to do around this Querétaro neighborhood?
Explore Santa Cruz's landmarks like Aqueduct of Santiago de Querétaro, Templo y Convento de la Santa Cruz, and Arches Viewpoint and learn about the local history. You could also plan a visit to Convent and Temple of Santa Cruz or Querétaro Contemporary Art Museum while you're in the neighborhood. Plaza de Los Fundadores, Casa de la Zacatecana Museum, and Ignacio Mena Rosales House of Culture are just a few of the places to visit in and around Santa Cruz. Plaza de Armas and Querétaro Regional Museum are also worth a visit when you're out sightseeing in Querétaro.