Find hotels near Saint Francis Healthcare System, Cape Girardeau from NT$2,028

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 22 - Dec 23
Tomorrow
Dec 23 - Dec 24
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Saint Francis Healthcare System hotels

Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
0.9 km from Saint Francis Healthcare System
7.2 out of 10, Good, (686)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is NT$1,818
NT$2,051 total
includes taxes & fees
Dec 29 - Dec 30
Quality Inn Cape Girardeau North
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
3.1 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1007)
"Great place and staff, very accommodating!"
United States
Megan
The price is NT$2,838
NT$3,202 total
includes taxes & fees
Jan 1 - 2026/1/2
Drury Plaza Hotel Cape Girardeau Conference Center
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (103)
"It was a nice stay"
United States
Douglas
The price is NT$2,821
NT$3,211 total
includes taxes & fees
Jan 1 - 2026/1/2
Tru By Hilton Cape Girardeau
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
2.7 km from Saint Francis Healthcare System
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is NT$1,736
NT$2,028 total
includes taxes & fees
Jan 4 - 2026/1/5
Town House Inn Cape Giradreau
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
3.6 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is NT$2,838
NT$3,202 total
includes taxes & fees
Jan 1 - 2026/1/2
Drury Inn & Suites Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
3.4 km from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is NT$2,208
NT$2,490 total
includes taxes & fees
Jan 1 - 2026/1/2
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
3.6 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is NT$2,872
NT$3,240 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
3.7 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is NT$3,209
NT$3,620 total
includes taxes & fees
Dec 29 - Dec 30
Hampton Inn Cape Girardeau I 55 East
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
4.1 km from Saint Francis Healthcare System
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is NT$4,740
NT$5,347 total
includes taxes & fees
Dec 28 - Dec 29
Rockwood Inn
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
4.2 km from Saint Francis Healthcare System
8.8 out of 10, Excellent, (673)
"Great place "
United States
GUY
The price is NT$2,656
NT$2,874 total
includes taxes & fees
Jan 7 - 2026/1/8
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
4.7 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is NT$2,776
NT$3,131 total
includes taxes & fees
Jan 1 - 2026/1/2
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
4.2 km from Saint Francis Healthcare System
8.2 out of 10, Very Good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is NT$2,517
NT$2,724 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Jackson-Cape Girardeau
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
5.3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is NT$3,659
NT$4,146 total
includes taxes & fees
Jan 1 - 2026/1/2
Courtyard by Marriott Cape Girardeau Downtown
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
5.3 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (476)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is NT$3,039
NT$3,429 total
includes taxes & fees
Dec 28 - Dec 29
The Riverview
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
4.9 km from Saint Francis Healthcare System
8.2 out of 10, Very Good, (885)
"Room was clean and spacious."
United States
George
The price is NT$2,429
NT$2,913 total
includes taxes & fees
Jan 21 - 2026/1/22
Candlewood Suites Cape Girardeau by IHG
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
3.5 km from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is NT$2,208
NT$2,490 total
includes taxes & fees
Jan 1 - 2026/1/2
Pear Tree Inn Cape Girardeau West
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
9.3 km from Saint Francis Healthcare System
7.6 out of 10, Good, (425)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is NT$2,214
NT$2,396 total
includes taxes & fees
Dec 25 - Dec 26
Town House Inn
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
12.3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1007)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is NT$2,618
NT$2,767 total
includes taxes & fees
Jan 15 - 2026/1/16
Drury Inn & Suites Jackson MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Saint Francis Healthcare System Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Breakfast great hot and big variety "
Terry 1-night trip
Posted 3 days ago
Pear Tree Inn Cape Girardeau West

Hotels near other Saint Francis Healthcare System attractions

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Cape Splash Family Aquatic Center

Bring the family to Cape Splash Family Aquatic Center and enjoy this exciting amusement park in Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Healthcare System?
Saint Francis Healthcare System is located in Cape Girardeau. This family-friendly area is known for its array of dining options. You'll find 61 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay close to Saint Francis Healthcare System?
Quality Inn Cape Girardeau North is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located just a short 0.6 mi (0.9 km) from Saint Francis Healthcare System. Other good options within a few miles include Drury Plaza Hotel Cape Girardeau Conference Center and La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau.
How many hotels should I expect to find near Saint Francis Healthcare System?
Expedia has 61 hotels and other accommodations a few miles from Saint Francis Healthcare System.
If I need to cancel the hotel reservation for my stay near Saint Francis Healthcare System, will I receive a refund?
Yes, the majority of room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals available near Saint Francis Healthcare System.
Where can I learn more about changing or cancelling my trip in the area near Saint Francis Healthcare System?
To find more details about updating your stay near Saint Francis Healthcare System or cancelling it, go to https://www.expedia.com/service/.
What can I see and do near Saint Francis Healthcare System?
You might spend a leisurely day outdoors at Cape Rock Park and Fort D Historic Site. Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center, and Lazy L Safari Park are fun stops for the whole family while you're in town. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.