Find hotels near Saint Francis Medical Center, Cape Girardeau from NT$2,028

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Dec 22 - Dec 23
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Dec 23 - Dec 24
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Dec 26 - Dec 28
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Our top choices for Saint Francis Medical Center hotels

Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
0.5 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is NT$3,209
NT$3,620 total
includes taxes & fees
Dec 29 - Dec 30
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
0.8 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (1007)
"Great place and staff, very accommodating!"
United States
Megan
The price is NT$2,838
NT$3,202 total
includes taxes & fees
Jan 1 - 2026/1/2
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
0.5 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is NT$2,872
NT$3,240 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
0.9 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is NT$2,838
NT$3,202 total
includes taxes & fees
Jan 1 - 2026/1/2
Drury Inn & Suites Cape Girardeau
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
1.5 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is NT$2,776
NT$3,131 total
includes taxes & fees
Jan 1 - 2026/1/2
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
0.4 km from Saint Francis Medical Center
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is NT$2,208
NT$2,490 total
includes taxes & fees
Jan 1 - 2026/1/2
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
1.6 km from Saint Francis Medical Center
8.2 out of 10, Very Good, (885)
"Room was clean and spacious."
United States
George
The price is NT$2,429
NT$2,913 total
includes taxes & fees
Jan 21 - 2026/1/22
Candlewood Suites Cape Girardeau by IHG
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
2 km from Saint Francis Medical Center
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is NT$1,736
NT$2,028 total
includes taxes & fees
Jan 4 - 2026/1/5
Town House Inn Cape Giradreau
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
0.8 km from Saint Francis Medical Center
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is NT$2,208
NT$2,490 total
includes taxes & fees
Jan 1 - 2026/1/2
Pear Tree Inn Cape Girardeau West
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
3.6 km from Saint Francis Medical Center
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is NT$4,740
NT$5,347 total
includes taxes & fees
Dec 28 - Dec 29
Rockwood Inn
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
4.3 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is NT$3,659
NT$4,146 total
includes taxes & fees
Jan 1 - 2026/1/2
Courtyard by Marriott Cape Girardeau Downtown
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
5.7 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (103)
"It was a nice stay"
United States
Douglas
The price is NT$2,821
NT$3,211 total
includes taxes & fees
Jan 1 - 2026/1/2
Tru By Hilton Cape Girardeau
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
4.9 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (476)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is NT$3,039
NT$3,429 total
includes taxes & fees
Dec 28 - Dec 29
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
6.7 km from Saint Francis Medical Center
8.8 out of 10, Excellent, (673)
"Great place "
United States
GUY
The price is NT$2,656
NT$2,874 total
includes taxes & fees
Jan 7 - 2026/1/8
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
15.3 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (1007)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is NT$2,618
NT$2,767 total
includes taxes & fees
Jan 15 - 2026/1/16
Drury Inn & Suites Jackson MO
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
6.7 km from Saint Francis Medical Center
8.2 out of 10, Very Good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is NT$2,517
NT$2,724 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Jackson-Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
3.8 km from Saint Francis Medical Center
7.2 out of 10, Good, (686)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is NT$1,818
NT$2,051 total
includes taxes & fees
Dec 29 - Dec 30
Quality Inn Cape Girardeau North
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
11.4 km from Saint Francis Medical Center
7.6 out of 10, Good, (425)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is NT$2,216
NT$2,398 total
includes taxes & fees
Dec 24 - Dec 25
Town House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Saint Francis Medical Center Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Breakfast great hot and big variety "
Terry 1-night trip
Posted 3 days ago
Pear Tree Inn Cape Girardeau West

Hotels near other Saint Francis Medical Center attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park

Riverfront Bridge Park

4.4/5 (74 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Medical Center?
Saint Francis Medical Center is located in Cape Girardeau. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, check out the 9 hotels and other accommodations you'll find within a mile.
Where is the best place to stay near Saint Francis Medical Center?
Adjacent to Saint Francis Medical Center, Pear Tree Inn Cape Girardeau Near the Medical Center is one of the top choices for your stay based on our traveler data, and this hotel offers free WiFi and LCD TVs. Other good options within a short distance include Drury Plaza Hotel Cape Girardeau Conference Center and Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.
How many hotels can I expect to find close to Saint Francis Medical Center?
Expedia has 9 hotels and other accommodations within a mile from Saint Francis Medical Center.
If I need to cancel the hotel reservation for my stay near Saint Francis Medical Center, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the top deals on offer near Saint Francis Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Saint Francis Medical Center?
For more information about changing or cancelling your stay near Saint Francis Medical Center, click here.
What can I see and do near Saint Francis Medical Center?
You might spend a leisurely day outdoors at Cape Rock Park and Fort D Historic Site. Create some family memories at Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.