Photo by Mike McClain

Find hotels in Puxico, MO from NT$1,750

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 10 - Dec 11
Tomorrow
Dec 11 - Dec 12
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Puxico hotels

Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (697)
"Amazing place"
United States
Mladen
The price is NT$3,274
NT$3,699 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Poplar Bluff by IHG
Seasonal outdoor pool, open 10:00 AM to 9:00 PM, pool umbrellas
Dexter Inn

Dexter Inn

2.5 star property
Dexter
7.0 out of 10, Good, (332)
"Room was nice and spacious."
United States
Rebecca
The price is NT$2,021
NT$2,269 total
includes taxes & fees
Dec 11 - Dec 12
Dexter Inn
In-room safe, desk, free WiFi, bed sheets
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2.0 star property
Poplar Bluff
6.6 out of 10, (622)
"The lady at the front was very nice. "
United States
Travis
The price is NT$1,723
NT$1,946 total
includes taxes & fees
Dec 18 - Dec 19
Super 8 by Wyndham Poplar Bluff Missouri
Terrace/patio
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is NT$2,894
NT$3,240 total
includes taxes & fees
Jan 4 - 2026/1/5
Hampton Inn Poplar Bluff
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (959)
"Nice room helpful staff. "
United States
Deborah
The price is NT$2,931
NT$3,311 total
includes taxes & fees
Dec 14 - Dec 15
Drury Inn & Suites Poplar Bluff
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (852)
"Very clean, great check in"
United States
Teresa
The price is NT$3,243
NT$3,664 total
includes taxes & fees
Jan 4 - 2026/1/5
Fairfield Inn & Suites by Marriott Poplar Bluff
Desk, iron/ironing board, free WiFi, bed sheets
Econo Lodge Dexter

Econo Lodge Dexter

2.0 star property
Dexter
6.8 out of 10, (250)
"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "
United States
Michelle
The price is NT$1,855
NT$2,083 total
includes taxes & fees
Jan 8 - 2026/1/9
Econo Lodge Dexter
Lobby
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1001)
"Love the updated rooms and the vending area."
United States
Kathi
The price is NT$2,370
NT$2,500 total
includes taxes & fees
Dec 11 - Dec 12
Motel 6 Poplar Bluff, MO
Lobby
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2.5 star property
Poplar Bluff
7.8 out of 10, Good, (397)
"Good breakfast selection for the price and clean room. "
United States
Jared
The price is NT$2,807
NT$3,171 total
includes taxes & fees
Jan 4 - 2026/1/5
Comfort Inn Poplar Bluff North
Fountain
Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge

2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (211)
"NO STAFF ON PHONE OR AT DESK. NO TOWELS! NO CUP! FILTHY COFFEE MAKER. At least the room was clean."
United States
Nicholas
Bullwinkles Rustic Lodge
Studio, 1 King Bed
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2.5 star property
Dexter
10.0 out of 10, Exceptional, (1)
"Staff was helpful and professional. The rooms were clean and comfortable "
United States
Michael
The price is NT$3,043
NT$3,417 total
includes taxes & fees
Dec 19 - Dec 20
Hampton Inn By Hilton Dexter
Deluxe Double Room | Premium bedding, individually decorated, individually furnished
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (83)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel
Exterior
OYO Hickory House Inn

OYO Hickory House Inn

2.5 star property
Dexter
5.4 out of 10, (128)
"Nice room very comfortable bed's"
United States
Jose
The price is NT$1,391
NT$1,750 total
includes taxes & fees
Jan 8 - 2026/1/9
OYO Hickory House Inn
Front of property
Lake Wappapello

Lake Wappapello

2.0 star property
Williamsville
10.0 out of 10, Exceptional, (1)
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."
United States
Dyann
The price is NT$4,303
NT$4,539 total
includes taxes & fees
Dec 20 - Dec 21
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico
Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"Clean and very well kept."
keith 1-night trip
Posted 2 days ago
Holiday Inn Poplar Bluff by IHG

More cheap stays in Puxico

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
The price is NT$2,370 per night from Dec 11 to Dec 12
NT$2,370
NT$2,500 total
Dec 11 - Dec 12
includes taxes & fees
7.8/10 Good! (1,003 reviews)

Hotels in Puxico with star-rating

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay based on our traveler data. Two other choices for your trip to the area are Holiday Inn Poplar Bluff by IHG and Fairfield Inn & Suites by Marriott Poplar Bluff. See all available top hotels, or vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
Where can I learn more about changing or cancelling my trip to Puxico?
To find more details about picking new dates or cancelling your trip to Puxico, click here.
What is staying in Puxico like?
Travelers to Puxico will find plenty to explore and enjoy. There are 53 hotels and other accommodations in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favorite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Check out what more to see and do in Expedia's Puxico guide.
What's the seasonal weather like in Puxico?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Puxico is 59 inches.

Explore a world of travel with Expedia