The Best Business Hotels in O'Fallon, MO from NT$2,602 in 2026

A city skyline with a prominent arch bridge and a lit bridge over a calm river reflecting city lights.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on O'Fallon Business Hotels

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for O'Fallon business-friendly hotels

43-inch LED TV with digital channels, TV

1. Comfort Inn & Suites St. Louis - O'Fallon

O'Fallon

Joy

NT$2,668

NT$3,146 total

includes taxes & fees

Aug 30 - Aug 31

Premium bedding, desk, iron/ironing board, WiFi (free)

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Josh

NT$2,638

NT$3,112 total

includes taxes & fees

Aug 9 - Aug 10

Hypo-allergenic bedding available, down comforters, pillowtop beds

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Sheria

NT$3,263

NT$3,848 total

includes taxes & fees

Aug 13 - Aug 14

Room, Accessible | Desk, iron/ironing board, WiFi (free), bed sheets

4. Super 8 by Wyndham O'Fallon MO/St. Louis Area

O'Fallon

Shelly

NT$2,206

NT$2,602 total

includes taxes & fees

Aug 9 - Aug 10

Desk, laptop workspace, blackout drapes, iron/ironing board

5. Residence Inn by Marriott O'Fallon

O'Fallon

Gerald

NT$4,224

NT$4,983 total

includes taxes & fees

Aug 28 - Aug 29

In-room safe, desk, laptop workspace, blackout drapes

6. Holiday Inn Express & Suites St Peters by IHG

St. Peters

Serah

NT$3,709

NT$4,461 total

includes taxes & fees

Sep 6 - Sep 7

7. Drury Inn & Suites St. Louis St. Peters

St. Peters

DANA

NT$3,547

NT$4,077 total

includes taxes & fees

Aug 30 - Aug 31

Desk, iron/ironing board, cribs (free), WiFi (free)

8. Courtyard by Marriott St. Louis St. Peters

St. Peters

Kimberley

NT$4,034

NT$4,839 total

includes taxes & fees

Sep 6 - Sep 7

View all properties

Top O'Fallon Hotel Reviews

Drury Inn & Suites St. Louis Airport

10/10 Excellent

"Excellent staff very friendly and willing to help. Good breakfast and fair evening repast."

Pear Tree Inn St. Louis Airport

8/10 Good

"Airport Shuttle at midnight was fast. Decent breakfast. We had an easy time getting on and off the property, and the long-term parking was gated. Thank you!"

The Wildwood Hotel

10/10 Excellent

"This place is great and so are the staff. I would not expect a place this nice to allow pets."

Hollywood Casino & Hotel St. Louis

8/10 Good

"Room was clean and comfortable. Did not care for the pillows, they were hard. Mini fridge in room but no microwave."

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"We stayed for one night while traveling home after visiting family, and we had a great experience. Our room was clean and comfortable, the staff was friendly and welcoming, and the complimentary breakfast offered a good variety of options to start the day. The location was also convenient for our travel needs. Overall, it was an excellent stay, and we would definitely choose to stay here again the next time we're in the area."

Motel 6 Hazelwood, MO

10/10 Excellent

"Nice place"

Sleep Inn & Suites O'Fallon MO - Technology Drive

8/10 Good

"Our room was clean, the hotel Is in a quiet/ safe area with restaurant's across the street. Breakfast was ok. Only issue was our room key daily deactivated and we had to return daily to reactive the key. Other then this we would stay again"

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"A very beautiful place. My son loved how they provided fountain soda and snacks."

Comfort Inn & Suites St. Louis - O'Fallon

10/10 Excellent

"Above and beyond service guest laundry available hotel front desk went extra mile by assisting with some paperwork I needed printing"

Frequently asked questions

How much do business-friendly hotels in O'Fallon cost?

Prices for business hotels in O'Fallon range between NT$2,602 and NT$5,427 per night. Whatever your budget, Expedia is here to help you locate the right space for a successful work trip. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the best business-friendly hotels in O'Fallon?

O'Fallon has multiple business-friendly hotels with a total average guest review rating of 8.8. One of the most popular is Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel. Get the job done from this 2.5-stars option, which includes a swimming pool and a firepit. Many corporate travelers also recommend Sleep Inn & Suites O'Fallon MO - Technology Drive. It has a 2.5-stars rating and amenities such as a swimming pool and front desk services.

How many business-friendly hotels are there in O'Fallon?

When work takes you to O'Fallon, you'll have 6 business-friendly hotels to select from. These properties combine a suitable location with the amenities corporate travelers need.

What are the best cheap business-friendly hotels in O'Fallon?

Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel is a good choice for corporate travelers in search of a money-saving option. It comes with amenities like pool sun loungers and a firepit. Another budget stay for a work trip is Sleep Inn & Suites O'Fallon MO - Technology Drive. A swimming pool and complimentary breakfast are two of the many conveniences here. Rates for business-friendly hotels in O'Fallon start from NT$2,602 per night, so you'll have more cash in your pocket to spend on non-work activities. When it's time to do a little sightseeing in O'Fallon, add a few free attractions to your work travel plans. August A. Busch Memorial Conservation Area and Quail Ridge Park are favorites. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

Are there any family-friendly hotels in O'Fallon that are also business friendly?

Taking a trip with the fam, and getting some work done, is a cinch at Country Inn & Suites by Radisson, St. Peters, MO. Take advantage of amenities including complimentary breakfast and pillow top mattresses at this 2.5-stars stay in O'Fallon. Also look into Residence Inn by Marriott O'Fallon. Finish your meetings and then spend quality time with your loved ones at this 3-stars option. Complimentary breakfast and an outdoor entertainment area are just the start of its many conveniences. Once you've finished work, there are lots of family-friendly attractions to explore around O'Fallon. Kokomo Joe's Family Fun Center and Alligator Creek Aquatic Center guarantee fun for young and old.

Why book your business-friendly hotel in O'Fallon with Expedia?

At Expedia, it's our job to help you land the ideal stay at the right price. From deluxe, corporate-friendly escapes to affordable motor inns filled with all the amenities you need, you'll have your next work trip planned in a few simple clicks.

How can I find cheap business-friendly hotels in O'Fallon?

When you're traveling for work in O'Fallon, our "business friendly" filter will help you find the ideal hotel. From free WiFi and included breakfast to meeting rooms and workspaces, they have the amenities you need for a comfortable and productive stay. Another tip? Narrow your search by your budget and preferred star rating to view the cheapest accommodations.

What is there to do in O'Fallon near my business-friendly hotel?

Whatever you love to do, O'Fallon has loads to keep you occupied. Kokomo Joe's Family Fun Center, National Equestrian Center and CarShield Field are on most visitors' sightseeing itineraries. Don't forget to check out August A. Busch Memorial Conservation Area, Missouri Bluffs Golf Course and Quail Ridge Park either. With Expedia's business-friendly hotel deals, you can see more terrific attractions like these with the money you save.

Explore a world of travel with Expedia

Book Business Hotels in O'Fallon on Expedia.com

Room 1

Change your mind

Treat yourself

Be picky

Check availability on O'Fallon Business Hotels

Our top choices for O'Fallon business-friendly hotels

1. Comfort Inn & Suites St. Louis - O'Fallon

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

3. Holiday Inn Express St. Louis West - O'Fallon by IHG