Find hotels in Mesopotamia from NT$2,055

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mesopotamia hotels

To Spiti tis Sofias

To Spiti tis Sofias
Kastoria
10.0 out of 10, Exceptional, (1)
"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin. "
France
Anonymous traveler
The price is NT$2,113
NT$2,418 total
includes taxes & fees
Jan 8 - 2026/1/9
To Spiti tis Sofias

Guesthouse Monopati

Guesthouse Monopati
Amyntaio
10.0 out of 10, Exceptional, (3)
Guesthouse Monopati

Kyknos De Luxe Hotel

Kyknos De Luxe Hotel
Kastoria
10.0 out of 10, Exceptional, (43)
"Very nice clean, very polite staff and great breakfast!"
United States
Vasilios
The price is NT$2,869
NT$3,314 total
includes taxes & fees
Dec 19 - Dec 20
Kyknos De Luxe Hotel

Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel
4.0 star property
Kastoria
9.0 out of 10, Wonderful, (84)
"The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing. "
United States
Michal
Esperos Palace Luxury & Spa Hotel

Guest House Ilektra

Guest House Ilektra
Voio
9.6 out of 10, Exceptional, (9)
"Wonderful views, easy to find, spacious rooms, and great hospitality."
United Kingdom
Maria
The price is NT$1,956
NT$2,240 total
includes taxes & fees
Dec 29 - Dec 30
Guest House Ilektra

Calma Hotel & Spa

Calma Hotel & Spa
4.0 star property
Kastoria
9.6 out of 10, Exceptional, (35)
"Pleasant stay. Good amenities. Great staff. "
New Zealand
Robert
Calma Hotel & Spa

Limneon Resort & Spa

Limneon Resort & Spa
4.0 star property
Kastoria
9.2 out of 10, Wonderful, (197)
"Wonderful stay. "
Canada
Konstantinos
The price is NT$3,421
NT$3,997 total
includes taxes & fees
Dec 21 - Dec 22
Limneon Resort & Spa

Guesthouse Vissinokipos

Guesthouse Vissinokipos
Kastoria
9.4 out of 10, Exceptional, (10)
"Wonderfull view and very friendly people.the place is avery dpecial artistic decorated.wonderfull weather.nice varieties for breakfast.price was ver good.i recommend it!"
United States
Carmen
Guesthouse Vissinokipos

Chloe Hotel

Chloe Hotel
3.0 star property
Kastoria
10.0 out of 10, Exceptional, (86)
"We enjoyed the stay, friendly staff and nice breakfast "
Australia
Fani
The price is NT$3,258
NT$3,756 total
includes taxes & fees
Dec 19 - Dec 20
Chloe Hotel

Anesis Hotel

Anesis Hotel
2.0 star property
Kastoria
9.0 out of 10, Wonderful, (9)
"Fantastic hotel in the heart of Kastoria. The owners are lovely people, very helpful and made me feel right at home. Will definitely stay there again!"
Canada
Adam
The price is NT$1,793
NT$2,055 total
includes taxes & fees
Jan 9 - 2026/1/10
Anesis Hotel

Andromeda Boutique hotel

Andromeda Boutique hotel
4.0 star property
Kastoria
8.8 out of 10, Excellent, (3)
Andromeda Boutique hotel

Anastasia s Kastoria Cozy Modern Garden Retreat

Anastasia s Kastoria Cozy Modern Garden Retreat
Kastoria
The price is NT$2,526
NT$4,475 total
includes taxes & fees
Dec 21 - Dec 22
Anastasia s Kastoria Cozy Modern Garden Retreat

The Sunset Haven Kastoria Modern Lake Elegance

The Sunset Haven Kastoria Modern Lake Elegance
Kastoria
The price is NT$2,898
NT$5,579 total
includes taxes & fees
Dec 20 - Dec 21
The Sunset Haven Kastoria Modern Lake Elegance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Mesopotamia Hotel Reviews

More cheap stays in Mesopotamia

Find out more about Mesopotamia

Top reasons to visit Mesopotamia

  • Stunning Natural Landscapes: Mesopotamia boasts breathtaking scenery, perfect for outdoor enthusiasts and romantic getaways.
  • Cultural Exploration: Visitors can delve into captivating history museums and notable landmarks that showcase the area's rich heritage.
  • Charming Village Atmosphere: Experience the picturesque charm of this village, with friendly locals and vibrant surroundings.
  • Family-Friendly Activities: Enjoy a variety of activities suitable for families, from scenic walks to local attractions.
  • Diverse Accommodation Options: Find a range of hotels, from luxury stays to cozy spots tailored for every traveler.

Find great hotels near Mesopotamia

Discover a range of hotels in Mesopotamia, Western Macedonia, Greece, tailored for every traveler. Whether you're seeking business-friendly accommodations, a rejuvenating spa experience, or an adventurous getaway, you'll find options that suit your needs. Enjoy competitive room rates and explore the best hotels in the area, ensuring a comfortable and memorable stay in this charming destination.

  • Hotel Anastassiou: Nestled 8.0km from Mesopotamia, Hotel Anastassiou is an adventurous haven for those seeking excitement and outdoor activities. Ideal for both business travelers and ski enthusiasts, this hotel provides easy access to ski lifts and shuttles. Guests can indulge in a variety of adventure sports nearby, such as kayaking, skiing lessons, and hiking. With a range of recreational activities available onsite or in close proximity, this property promises a thrilling stay for those looking to explore the great outdoors.
  • Kyknos De Luxe Hotel: Located 8.0km away from Mesopotamia, Kyknos De Luxe Hotel offers a luxurious experience for discerning travelers. This 3.5-star hotel combines elegance with comfort, making it perfect for business trips or upscale vacations. Guests can expect top-notch amenities and service, ensuring a relaxing retreat after a day of exploration. The hotel's sophisticated ambiance and attentive staff make it a favored choice for those who appreciate the finer things in life.
  • Esperos Palace Luxury & Spa Hotel: Just 8.0km from Mesopotamia, the 4-star Esperos Palace Luxury & Spa Hotel is the ultimate destination for relaxation and rejuvenation. This spa-themed hotel features a comprehensive wellness center offering an array of services, including body and facial treatments, manicures, and an indoor pool. Perfect for business travelers seeking a tranquil escape, guests can unwind in a serene environment designed to enhance their well-being. With its luxurious amenities and commitment to relaxation, Esperos Palace promises a restorative getaway.

Where to stay in Mesopotamia

Experience the charm of Mesopotamia, a picturesque village in Western Macedonia, perfect for outdoor and romantic getaways. Explore the scenic landscapes and enjoy family-friendly activities in the surrounding areas. Visit nearby towns to soak in the vibrant atmosphere, from trendy cafes to luxury accommodations. Don't miss the breathtaking city views and the warm hospitality of the locals as you uncover the rich culture and natural beauty that this enchanting region has to offer.

  • Kastoria: Nestled in the scenic landscapes of Western Macedonia, Kastoria is a captivating city that offers a unique blend of natural beauty and cultural heritage. Known for its stunning lakeside views and surrounding mountains, it's an ideal destination for outdoor enthusiasts seeking adventure and picturesque scenery. Visitors flock to Kastoria year-round, but the peak seasons in September and November to December bring a vibrant atmosphere. Popular activities include skiing at nearby resorts, indulging in local spas, and exploring historic sites like monasteries. The city's charming ambiance and rich history make it a must-visit on your itinerary.
  • Árgos Orestikón: Just 9.7km from Mesopotamia, Árgos Orestikón is a delightful city that embraces adventure and outdoor activities. With visitor numbers peaking in September and during the winter months of December to January, this city provides a welcoming environment for travelers seeking a blend of nature and culture. The surrounding valleys offer breathtaking views and opportunities for hiking and exploration. Árgos Orestikón's proximity to Kastoria enhances its appeal, making it a perfect stop for those looking to experience the beauty of Western Macedonia.
  • Dispilio: Located 11.3km from Mesopotamia, Dispilio is a quaint village that offers a charming escape for those looking to immerse themselves in nature. The village sees a moderate influx of visitors, particularly during the summer months of July to September. Dispilio is renowned for its beautiful beaches, serene lake, and various museums that showcase local history. Adventure seekers will find plenty of skiing options at nearby resorts, making it an ideal spot for both winter and summer activities. The tranquil atmosphere and stunning landscapes make Dispilio a memorable destination.

Things to do in Mesopotamia

Mesopotamia, nestled in Kastoria, Western Macedonia, Greece, is perfect for scenic outdoor and romantic getaways. Visitors can enjoy various activities, including trips to explore the stunning landscapes and local culture. While there may not be a traditional amusement park, the area's natural beauty and charming ambiance provide plenty of opportunities for relaxation and adventure, making it an ideal destination for memorable experiences.

Shopping

In Mesopotamia, enjoy local shops offering traditional crafts and souvenirs. If you're up for a drive, visit the nearby Kozani Shopping Center, about 19.3km away, for a wider selection of stores, including fashion boutiques and local delicacies.

Recreation

In Mesopotamia, the stunning Lake Orestiada area hosts serene wellness retreats, featuring rejuvenating spa treatments amidst breathtaking landscapes. Enjoy yoga sessions by the water and indulge in locally sourced organic cuisine, all while soaking in the tranquil atmosphere of this enchanting region.

Adventure

Explore the ancient ruins of the Ziggurat of Ur, where you can marvel at the impressive architecture and learn about Mesopotamian history. For a thrill, try river rafting on the Tigris River, enjoying the rush of the rapids and the stunning landscapes surrounding you.

Nightlife

Experience the vibrant nightlife in Mesopotamia by visiting the trendy La Belle Vie Lounge for signature cocktails and a lively atmosphere. For a more laid-back vibe, check out the local tavern, where you can enjoy traditional Greek dishes accompanied by live music and friendly locals.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Mesopotamia

To save money during your visit to Mesopotamia, consider traveling in March or October to November when prices are lower. Book your hotel about a month in advance for the best rates, and look for last-minute deals on platforms like Expedia. Tuesdays tend to be the cheapest days for hotel stays, while Thursdays are the most expensive. Use Expedia’s search tools to filter by budget and location, and consider bundling your hotel, flights, and activities for additional savings. Don't forget to check for special offers and travel rewards to maximize your budget.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Mesopotamia are March and October to November, where the prices are slightly lower. This is in comparison to April and July to August, where prices are slightly higher.
  • The best time to book a hotel: Book your hotel in Mesopotamia about 1 month out to secure some of the cheapest prices. If you're the spontaneous type, Expedia's last minute deals and discounts are indicated via the green label below the price.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Mesopotamia is Tuesday. The most expensive day to stay in Mesopotamia is Thursday.
  • Find cheap hotels on Expedia: Utilize the search tool on Expedia to customize your options based on your budget, preferred location, and the type of hotel you desire. To find the best prices and special offers, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Mesopotamia with your flights and activities through an Expedia package.

Find the best attractions near Mesopotamia

Mesopotamia in Western Macedonia, Greece, is perfect for scenic, outdoor, and romantic getaways. Visitors can explore captivating points of interest, including beautiful lakes, intriguing history museums, and notable landmarks. The area's attractions cater to those seeking cultural experiences, beach relaxation, and outdoor adventures, making it a diverse destination for all types of travelers.

  • Kastoria Lake: Nestled just 8.0km from Mesopotamia, Kastoria Lake offers stunning views and a romantic atmosphere. Enjoy outdoor activities like walking or cycling along the scenic shoreline, where you can soak in the natural beauty and tranquility of the area.
  • Folklore Museum of Kastoria: Located 8.0km away, this museum immerses you in the rich culture and history of the region. Explore fascinating exhibits showcasing traditional crafts, costumes, and artifacts that reflect the local heritage.
  • Taxiarhia of the Metropolis: This landmark, also 8.0km from Mesopotamia, combines trendy and luxurious vibes with budget-friendly options. Marvel at its architectural beauty and enjoy surrounding cafes and shops that highlight the vibrant local lifestyle.

Best time to go to Mesopotamia

The best time to visit Mesopotamia is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are moderately high and weather is sunny with no rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January32.5°F (0.3°C)Light RainMostly SunnyModerately LowAverage
February36.1°F (2.3°C)Light RainMostly SunnyModerately LowAverage
March41.7°F (5.4°C)Light RainMostly SunnyAverageSlightly Low
April50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly High
May57.9°F (14.4°C)Light RainMostly SunnyAverageAverage
June66.0°F (18.9°C)No RainMostly SunnyAverageAverage
July72.3°F (22.4°C)No RainSunnyModerately HighSlightly High
August72.5°F (22.5°C)No RainSunnyModerately HighSlightly High
September64.2°F (17.9°C)No RainMostly SunnyModerately HighAverage
October54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
November45.1°F (7.3°C)Light RainMostly SunnyModerately LowSlightly Low
December36.3°F (2.4°C)Light RainMostly SunnyAverageAverage

The nearest major airports for your trip to Mesopotamia

For travelers heading to Mesopotamia, the nearest airports are Kozani (KZI-Filippos) and Kastoria (KSO-Aristoteles). Kozani Airport is situated 61.2km from Mesopotamia, with nearby hotels like the 3.5-star Tselikas Hotel located 1.6km away and Anesis Hotel just 3.2km from the airport. Kastoria Airport is much closer at 11.3km, offering luxury accommodations such as the 5-star Limneon Resort & Spa, 4.8km away, and Orologopoulos Mansion, 8.0km from the airport. These hotels often provide transportation services, including airport shuttles and transfers, making travel convenient for visitors.

Frequently asked questions

Where is the best place for a stay in Mesopotamia?
To Spiti tis Sofias is one of the top choices for your stay based on our traveler data. This guesthouse offers free parking and free WiFi. Two other choices for your visit to the area are Limneon Resort & Spa and Hotel Anastassiou. See all available top hotels, or vacation rentals in Mesopotamia.
What are some of the best vacation home rentals that Mesopotamia has to offer?
The Sunset Haven Kastoria Modern Lake Elegance: This vacation home rental outside of Mesopotamia offers a barbecue grill and free WiFi to help you feel comfortable in your new surroundings. See all vacation rentals in Mesopotamia.
If I need to cancel my hotel reservation in Mesopotamia, will I receive a refund?
Yes! You'll find that most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Mesopotamia.
Where can I learn more about changing or cancelling my trip to Mesopotamia?
For more details about picking new dates or cancelling your trip to Mesopotamia, click here.
What is the best accommodation for staying close to Macedonia Airport (SKG)?
Hyatt Regency Thessaloniki is a popular 5-star hotel featuring 2 outdoor pools and a full-service spa. It's located a short 1.1 mi (1.8 km) from Macedonia Airport. Other options near the airport are Athina Airport Hotel and Hotel Nikopolis.
What is staying in Mesopotamia like?
Travelers to Mesopotamia will find plenty to explore and enjoy. There are 46 hotels and other accommodations in the surrounding area. Find out more about Mesopotamia.
What are the top places to visit in Mesopotamia?
Places to visit in the wider area include Kastoria Aquarium, Kastoria Lake, and Neolithic Lakeside Settlement. You'll also find Folklore Museum of Kastoria and Byzantine Museum of Kastoria in the area. Check out what more to see and do in Expedia's Mesopotamia guide.
What's the seasonal weather like in Mesopotamia?
The hottest months are usually August and July with an average temp of 69°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Mesopotamia is 28 inches.

Explore a world of travel with Expedia