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Dec 15 - Dec 16
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Dec 16 - Dec 17
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for Louisville Science Center hotels

Interior entrance
Louisville Bourbon Inn

Louisville Bourbon Inn

Louisville Bourbon Inn
5.0 star property
Old Louisville, 2.9 km from Louisville Science Center
10.0 out of 10, Exceptional, (20)
"Great breakfast. Frittata, French toast, eggs, bacon, sausage, grapes, toast, biscuits and gravy - all were excellent. "
United States
Gaven
The price is NT$8,266
NT$9,595 total
includes taxes & fees
Dec 17 - Dec 18
Louisville Bourbon Inn
Terrace/patio
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is NT$5,463
NT$6,428 total
includes taxes & fees
Dec 29 - Dec 30
Hotel Distil, Autograph Collection
Interior entrance
Market Street Inn

Market Street Inn

Market Street Inn
3.5 star property
2.1 km from Louisville Science Center
9.8 out of 10, Exceptional, (120)
"I enjoyed my stay, however the breakfast portion was very small even for a petite person like myself, I was still very hungry after breakfast. There was a cleaning issue with the bathroom that was overlooked by the cleaning staff that I alerted the owners to that will hopefully be fixed for future visitors. The house is great and very clean overall. The owners are very nice."
United States
Megan
The price is NT$5,779
NT$6,530 total
includes taxes & fees
Dec 17 - Dec 18
Market Street Inn
Lobby
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville, 0.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1002)
"Room was great, Bed super comfy, staff was excellent, restaurant was awesome! Highly recommend!"
United States
Andrew
The price is NT$4,520
NT$5,318 total
includes taxes & fees
Dec 25 - Dec 26
The Grady
Front of property
DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
3.0 star property
Old Louisville, 2.8 km from Louisville Science Center
9.8 out of 10, Exceptional, (97)
"Breakfast was wonderful, great place to stay!"
United States
Janie
The price is NT$4,455
NT$5,171 total
includes taxes & fees
Dec 17 - Dec 18
DuPont Mansion Bed & Breakfast
Dining
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
3.0 star property
Downtown Louisville, 1.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1005)
"All the staff we met were really nice! The rooms are clean and spacious."
United States
Kelly Anne
The price is NT$2,718
NT$3,198 total
includes taxes & fees
Dec 25 - Dec 26
Cambria Hotel Louisville Downtown-Whiskey Row
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 1.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1154)
"I loved everything about this place"
United States
Steven
The Brown Hotel
Lounge
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
East Market District, 2.2 km from Louisville Science Center
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is NT$3,681
NT$5,901 total
includes taxes & fees
Dec 29 - Dec 30
Stellar Suites
Terrace/patio
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
3.0 star property
Downtown Louisville, 0.2 km from Louisville Science Center
9.2 out of 10, Wonderful, (1005)
"The room was wonderful and the staff exceptional."
United States
Daniel
The price is NT$3,119
NT$3,670 total
includes taxes & fees
Jan 10 - 2026/1/11
Homewood Suites by Hilton Louisville Downtown, KY
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville, < 0.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (1002)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is NT$4,336
NT$5,258 total
includes taxes & fees
Jan 1 - 2026/1/2
21c Museum Hotel Louisville
Property amenity
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
3.0 star property
Downtown Louisville, 0.3 km from Louisville Science Center
9.2 out of 10, Wonderful, (509)
"Great rooms "
United States
Ayden
The price is NT$3,026
NT$3,560 total
includes taxes & fees
Dec 30 - Dec 31
Towneplace Suites By Marriott Louisville Downtown
3 bars/lounges, cocktail bar, lobby lounge
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.2 out of 10, Wonderful, (1735)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is NT$5,216
NT$6,137 total
includes taxes & fees
Jan 1 - 2026/1/2
Omni Louisville Hotel
2 restaurants, breakfast served
Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 2.1 km from Louisville Science Center
9.4 out of 10, Exceptional, (823)
"Love the hotel and will always stay there when visiting "
United States
Jeremy
The price is NT$3,200
NT$3,765 total
includes taxes & fees
Jan 4 - 2026/1/5
Tempo By Hilton Louisville Downtown Nulu
Interior entrance
Moxy Louisville Downtown

Moxy Louisville Downtown

Moxy Louisville Downtown
3.5 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.2 out of 10, Wonderful, (698)
"Awesome location and the staff was super friendly"
United States
Kelly
The price is NT$3,026
NT$3,560 total
includes taxes & fees
Dec 27 - Dec 28
Moxy Louisville Downtown
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 0.5 km from Louisville Science Center
9.0 out of 10, Wonderful, (3879)
"Beautiful room and great hospitality. "
United States
Chase
The price is NT$4,158
NT$4,892 total
includes taxes & fees
Dec 20 - Dec 21
Galt House Hotel Trademark Collection by Wyndham
Exterior detail
Central Park Bed & Breakfast

Central Park Bed & Breakfast

Central Park Bed & Breakfast
4.0 star property
Old Louisville, 3 km from Louisville Science Center
9.4 out of 10, Exceptional, (57)
"Our stay here was excellent in every way! The owners were very sweet and went out of their way to assist us in every way, the rooms were very cozy, and the breakfasts were fantastic. This is the best B&B we've ever stayed."
United States
John
The price is NT$4,229
NT$4,909 total
includes taxes & fees
Dec 17 - Dec 18
Central Park Bed & Breakfast
Reception
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.0 out of 10, Wonderful, (1115)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is NT$3,469
NT$4,081 total
includes taxes & fees
Dec 28 - Dec 29
Embassy Suites Louisville Downtown
Terrace/patio
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 2.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (1016)
"Nice hotel! "
United States
Stephanie
The price is NT$3,962
NT$4,661 total
includes taxes & fees
Dec 25 - Dec 26
Hotel Genevieve part of JdV by Hyatt
Lobby lounge
AC Hotel Louisville Downtown

AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
3.5 star property
East Market District, 2.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (601)
"Loved the Hotel and area around the Hotel. Great shopping and restaurants"
United States
Melissa
The price is NT$2,940
NT$3,459 total
includes taxes & fees
Dec 26 - Dec 27
AC Hotel Louisville Downtown
Restaurant
Aloft Louisville Downtown

Aloft Louisville Downtown

Aloft Louisville Downtown
3.0 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.0 out of 10, Wonderful, (1005)
"Good"
United States
Les
The price is NT$3,135
NT$3,689 total
includes taxes & fees
Dec 25 - Dec 26
Aloft Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Louisville Science Center Hotel Reviews

Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent
"Loved the shower: hot water, the glass curved door, stepping in a shower, not a tub, the high shower head, plenty of head room. The water pressure could have been harder. Our corner room was clean. Loved the full length mirror in the hallway. Not super quiet as our room faced the street, but we managed."
Linda 1-night trip
Posted 4 days ago
Holiday Inn Express & Suites Louisville Downtown by IHG

Hotels near other Louisville Science Center attractions

Exploration of Louisville Slugger Museum in Downtown Louisville, Kentucky on a Sunny Day

Louisville Slugger Museum

4.5/5 (1,200 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
See properties
A great stop! This has to be one of the best museums I’ve been about somebody! Great stop and a fantastic life!
Photo by Corey Dargan
Open Photo by Corey Dargan

Muhammad Ali Center

4.3/5 (298 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
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Frequently asked questions

What's the area like around Louisville Science Center?
Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 291 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Louisville Science Center?
Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.
How many hotels can I expect to find close to Louisville Science Center?
Expedia has 291 hotels and other accommodations within a mile from Louisville Science Center.
If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.
Where can I learn more about changing or cancelling my trip in the area near Louisville Science Center?
For more details about picking new dates or cancelling your stay near Louisville Science Center, click here.
What can I see and do near Louisville Science Center?
21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Thomas Edison House. You can catch a show at Kentucky Center for the Performing Arts, Louisville Palace, and Derby Dinner Playhouse.

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