A nighttime cityscape with a brightly lit bridge and a skyline featuring a prominent dome-shaped building.

Find Resorts & Hotels with Spas in Jeffersonville, IN

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Jeffersonville Resorts & Hotels with Spas

This weekend
Jul 31 - Aug 2
Next weekend
Aug 7 - Aug 9

Our top choices for Jeffersonville hotels with a spa

4 restaurants; breakfast, lunch, and dinner served

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,181 reviews)
  • cleanliness
    Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
The price is NT$5,143
NT$6,051 total
includes taxes & fees
Aug 1 - Aug 2
Galt House Hotel Trademark Collection by Wyndham
3 bars/lounges, cocktail bar, lobby lounge

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (2,029 reviews)
  • cleanliness
    Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
The price is NT$5,158
NT$6,069 total
includes taxes & fees
Aug 2 - Aug 3
Omni Louisville Hotel
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,001 reviews)
  • cleanliness
    Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
The price is NT$4,912
NT$5,941 total
includes taxes & fees
Aug 23 - Aug 24
21c Museum Hotel Louisville
3 restaurants; breakfast, lunch, and dinner served

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
3.5 star property
Elizabeth
8.2 out of 10, Very Good, (1,004 reviews)
  • cleanliness
    Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
The price is NT$2,174
NT$3,059 total
includes taxes & fees
Aug 27 - Aug 28
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
Bar (on property)

Pillow and Paddock B&B

Pillow and Paddock B&B
3.5 star property
La Grange
10.0 out of 10, Exceptional, (52 reviews)
  • cleanliness
    Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
The price is NT$13,226
NT$14,581 total
includes taxes & fees
Aug 5 - Aug 6
Pillow and Paddock B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Jeffersonville

Pool
Breakfast included

Top Jeffersonville Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Jeffersonville?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers recommend the riverfront and gourmet restaurants in Jeffersonville. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your weekend away.
What's there to see and do in Jeffersonville?
Experience Jeffersonville with a stop at Charlestown State Park, Ohio River Valley, and Howard Steamboat Museum. If you have some spare time during your trip, you might want to check out River City Park and Schimpffs Confectionery.
What is a Jeffersonville spa hotel?
Spa hotels in Jeffersonville provide lodging and have an on-site spa offering services including therapies and body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Explore a world of travel with Expedia