Find Luxury Hotels in Florence, SC

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Check availability on Florence Luxury Hotels

Tonight
Dec 22 - Dec 23
Tomorrow
Dec 23 - Dec 24
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Florence luxury hotels

Rooftop terrace
The Mantissa Hotel

The Mantissa Hotel

The Mantissa Hotel
3.0 star property
Hartsville
9.2 out of 10, Wonderful, (270)
"Very nice spacious rooms friendly staff"
United States
Duane
The price is NT$5,113
NT$5,727 total
includes taxes & fees
Dec 29 - Dec 30
The Mantissa Hotel
Exterior
Days Inn by Wyndham Dillon

Days Inn by Wyndham Dillon

Days Inn by Wyndham Dillon
2.0 star property
Dillon
5.4 out of 10, (870)
"Really enjoyed my stay"
United States
Josh
The price is NT$1,878
NT$2,103 total
includes taxes & fees
Dec 29 - Dec 30
Days Inn by Wyndham Dillon
Bar (on property)
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton
3.0 star property
Florence
8.8 out of 10, Excellent, (604)
"Special place. Great staff with an outstanding restaurant "
United States
John D
The price is NT$4,115
NT$4,609 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Florence, Tapestry Collection by Hilton
Free daily on-the-go breakfast
Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North
2.0 star property
Florence
6.8 out of 10, (1004)
"Clean room , quite area , walking distance "
United States
Gisell
The price is NT$1,851
NT$2,073 total
includes taxes & fees
Dec 23 - Dec 24
Days Inn by Wyndham Florence/I-95 North
Lobby
Clarion Inn & Suites Florence - Darlington

Clarion Inn & Suites Florence - Darlington

Clarion Inn & Suites Florence - Darlington
2.5 star property
Florence
4.4 out of 10, (292)
"It appears the property is under new management and possible being updated. The room was very inexpensive and the staff charge a deposit refundable typically 3-5 business days almost as much as room cost. My room was prepaid before I arrived. "
United States
Kathleen
The price is NT$1,618
NT$1,812 total
includes taxes & fees
Dec 24 - Dec 25
Clarion Inn & Suites Florence - Darlington
Desk, laptop workspace, free cribs/infant beds, free WiFi
Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center
2.0 star property
Florence
6.8 out of 10, (1003)
"Small Budget motel room "
United States
Hi Tech Travel and Tours
The price is NT$1,769
NT$1,981 total
includes taxes & fees
Dec 25 - Dec 26
Red Roof Inn Florence - Civic Center
Desk, iron/ironing board, free WiFi, bed sheets
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center
2.5 star property
Florence
6.8 out of 10, (1007)
"Staff was friendly and the hotel was easy access to I95 which made it stress free. Room was clean and the Heat worked! "
United States
Robert Patrick
The price is NT$2,083
NT$2,333 total
includes taxes & fees
Dec 30 - Dec 31
Days Inn by Wyndham Florence Near Civic Center
Standard Room, 1 King Bed with Sofa bed, Non Smoking | Desk, iron/ironing board, rollaway beds, free WiFi
Quality Inn Dillon

Quality Inn Dillon

Quality Inn Dillon
2.5 star property
Dillon
7.2 out of 10, Good, (762)
"Breakfast was warmly set up and complementary with all we needed."
United States
George
The price is NT$2,522
NT$2,824 total
includes taxes & fees
Jan 20 - 2026/1/21
Quality Inn Dillon
Premium bedding, in-room safe, desk, iron/ironing board
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center
2.5 star property
Florence
7.8 out of 10, Good, (1257)
"Room was spotless and the staff was friendly..."
United States
Randy
The price is NT$2,493
NT$2,792 total
includes taxes & fees
Dec 30 - Dec 31
Quality Inn & Suites Florence Civic Center
Free daily continental breakfast
Red Roof Inn Dillon, SC

Red Roof Inn Dillon, SC

Red Roof Inn Dillon, SC
2.0 star property
Dillon
6.4 out of 10, (977)
"Very nice 👍 "
United States
Luz
The price is NT$1,830
NT$2,050 total
includes taxes & fees
Dec 23 - Dec 24
Red Roof Inn Dillon, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Florence Hotel Reviews

Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

10/10 Excellent
"Staff was friendly and the hotel was easy access to I95 which made it stress free. Room was clean and the Heat worked! "
Robert Patrick 1-night trip
Posted 6 days ago
Days Inn by Wyndham Florence Near Civic Center
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

10/10 Excellent
"Newly remodeled rooms. Very clean. Very friendly staff "
Theresa 1-night trip
Posted 6 days ago
Quality Inn & Suites Florence Civic Center

Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Florence?
Expedia can help you get a flight to Florence, SC (FLO-Florence Regional) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you'd like to make your stay special. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Florence offers. During your visit, you might want to enjoy the shopping which Florence is known for.
When can I expect good weather in Florence?
Planning for the weather is a good way to make your trip to Florence relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 78°F, while the coldest months are January and February with an average of 50°F. Average annual precipitation for Florence is 54 inches.
What's there to see and do in Florence?
Take in the sights and attractions that Florence offers with a visit to Florence Museum, Florence National Cemetery, and Dr. Eddie Floyd Tennis Center. If you have extra time while you're in the area, you might want to stop by Magnolia Mall and Florence Civic Center.
How can I get around Florence?
It's easier to get around town in style when you know your options. If you want to venture outside of the area, hop aboard a train at Florence Station.

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