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Find Family Hotels in Cape Girardeau, MO

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Check availability on Cape Girardeau Family Hotels

Our top choices for Cape Girardeau family-friendly hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is NT$2,807
NT$3,167 total
includes taxes & fees
Dec 21 - Dec 22
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (139)
"Nice hotel, clean and comfortable "
United States
Laura
The price is NT$2,745
NT$3,097 total
includes taxes & fees
Dec 25 - Dec 26
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1002)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is NT$2,183
NT$2,463 total
includes taxes & fees
Dec 19 - Dec 20
Pear Tree Inn Cape Girardeau Near the Medical Center
Property amenity
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (881)
"Clean room, low noise and very comfortable!"
United States
Richard
The price is NT$2,184
NT$2,635 total
includes taxes & fees
Jan 11 - 2026/1/12
Candlewood Suites Cape Girardeau by IHG
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is NT$2,183
NT$2,463 total
includes taxes & fees
Dec 21 - Dec 22
Pear Tree Inn Cape Girardeau West
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (668)
"Great place "
United States
GUY
The price is NT$2,625
NT$2,841 total
includes taxes & fees
Jan 7 - 2026/1/8
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Free daily on-the-go breakfast
Hotel 7 Inn Anna

Hotel 7 Inn Anna

Hotel 7 Inn Anna
2.5 star property
Anna
6.6 out of 10, (217)
"The staff was wonderful"
United States
Donna
The price is NT$2,555
NT$2,963 total
includes taxes & fees
Dec 17 - Dec 18
Hotel 7 Inn Anna
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Very friendly staff and great breakfast"
Ray 1-night trip
Posted 5 days ago
Drury Inn & Suites Cape Girardeau

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Frequently asked questions

What's Cape Girardeau like for family-friendly vacations?
You might want to consider the historic destination of Cape Girardeau if you've been thinking about a trip for the whole family. The restaurants here makes this an attractive vacation spot for families. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is the closest airport, or Cairo, IL (CIR-Cairo Regional), which is located 23.4 mi (37.6 km) from the city center.
What's the best accommodation for a family vacation to Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it's a top choice on Expedia for families. Other good options for your family trip include Pear Tree Inn Cape Girardeau Near the Medical Center and Pear Tree Inn Cape Girardeau West.
When's the best time to book a family-friendly vacation in Cape Girardeau?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do with your family in Cape Girardeau?
While you and your family are visiting Cape Girardeau, you might want to check out some kid-friendly attractions such as Show Me Center, Cape Splash Family Aquatic Center, and Cape Girardeau Conservation Nature Center. Make sure you have lots of time for activities like Lazy L Safari Park and The Glenn House.